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Accelerated endothelialization with a polymer-free sirolimus-eluting antibody-coated stent
Yu, Zhanjiang1,2; Zhu, Huagang3; Lu, Shuzheng3; Yang, Xiaoda1,2
刊名JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
2013-11-01
DOI10.1007/s10856-013-5009-z
24期:11页:2601-2609
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者Nature Science Foundation of China (NSFC) ; Research Fund for the Doctoral Program of Higher Education of China ; Nature Science Foundation of China (NSFC) ; Research Fund for the Doctoral Program of Higher Education of China
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]PROGENITOR-CELL CAPTURE ; BARE-METAL STENTS ; CORONARY STENTS ; RESTENOSIS ; THROMBOSIS ; EFFICACY ; REGISTRY ; SURFACE ; MATRIX ; SAFETY
英文摘要

Drug-eluting stents have shown an impressive reduction of in-stent restenosis for many years. However, stent thrombosis due to incomplete/late endothelialization has raised major safety concerns. To overcome these problems, we developed for the first time a polymer-free sirolimus-eluting antibody-coated stent (PFSEACS) by combining polymer free and endothelial progenitor cell-capture pro-healing approaches. In the first phase, the stents were prepared by loading sirolimus on the porous outer stent surface and directly fixing the anti-CD34 antibodies without any medium carriers on the blood contacting surface. The dose and elution of sirolimus, the amount and stability of anti-CD34 antibody immobilization, and the rate of CD34+ cell capture were evaluated. In the second phase, the stents were validated in an animal model of coronary arteries in pigs. The stent was observed to start collecting endothelial progenitor cells similar to 2 h after stent implantation and exhibited greatly enhanced endothelialization while maintaining an excellent anti-restenosis activity comparable to the polymer-free sirolimus-eluting stents. Overall, both in vitro and in vivo evaluations indicated that novel PFSEACSs exhibited facilitated endothelialization with excellent anti-restenosis activity and thus should merit further clinical studies.

语种英语
所属项目编号30770581 ; 20971008
资助者Nature Science Foundation of China (NSFC) ; Research Fund for the Doctoral Program of Higher Education of China ; Nature Science Foundation of China (NSFC) ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号WOS:000326049900012
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58208
专题北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Capital Univ Med Sci, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Yu, Zhanjiang,Zhu, Huagang,Lu, Shuzheng,et al. Accelerated endothelialization with a polymer-free sirolimus-eluting antibody-coated stent[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2013,24(11):2601-2609.
APA Yu, Zhanjiang,Zhu, Huagang,Lu, Shuzheng,&Yang, Xiaoda.(2013).Accelerated endothelialization with a polymer-free sirolimus-eluting antibody-coated stent.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,24(11),2601-2609.
MLA Yu, Zhanjiang,et al."Accelerated endothelialization with a polymer-free sirolimus-eluting antibody-coated stent".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 24.11(2013):2601-2609.
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