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学科主题: 药学
题名:
Accelerated endothelialization with a polymer-free sirolimus-eluting antibody-coated stent
作者: Yu, Zhanjiang1,2; Zhu, Huagang3; Lu, Shuzheng3; Yang, Xiaoda1,2
刊名: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
发表日期: 2013-11-01
DOI: 10.1007/s10856-013-5009-z
卷: 24, 期:11, 页:2601-2609
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: PROGENITOR-CELL CAPTURE ; BARE-METAL STENTS ; CORONARY STENTS ; RESTENOSIS ; THROMBOSIS ; EFFICACY ; REGISTRY ; SURFACE ; MATRIX ; SAFETY
英文摘要:

Drug-eluting stents have shown an impressive reduction of in-stent restenosis for many years. However, stent thrombosis due to incomplete/late endothelialization has raised major safety concerns. To overcome these problems, we developed for the first time a polymer-free sirolimus-eluting antibody-coated stent (PFSEACS) by combining polymer free and endothelial progenitor cell-capture pro-healing approaches. In the first phase, the stents were prepared by loading sirolimus on the porous outer stent surface and directly fixing the anti-CD34 antibodies without any medium carriers on the blood contacting surface. The dose and elution of sirolimus, the amount and stability of anti-CD34 antibody immobilization, and the rate of CD34+ cell capture were evaluated. In the second phase, the stents were validated in an animal model of coronary arteries in pigs. The stent was observed to start collecting endothelial progenitor cells similar to 2 h after stent implantation and exhibited greatly enhanced endothelialization while maintaining an excellent anti-restenosis activity comparable to the polymer-free sirolimus-eluting stents. Overall, both in vitro and in vivo evaluations indicated that novel PFSEACSs exhibited facilitated endothelialization with excellent anti-restenosis activity and thus should merit further clinical studies.

语种: 英语
所属项目编号: 30770581 ; 20971008
项目资助者: Nature Science Foundation of China (NSFC) ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000326049900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58208
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Capital Univ Med Sci, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China

Recommended Citation:
Yu, Zhanjiang,Zhu, Huagang,Lu, Shuzheng,et al. Accelerated endothelialization with a polymer-free sirolimus-eluting antibody-coated stent[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2013,24(11):2601-2609.
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