IR@PKUHSC  > 北京大学第三临床医学院  > 肾内科
学科主题临床医学
Changes of urinary phospholipids in the chronic kidney disease patients
Yang, Wen-Ling1; Bai, Qiong1; Li, Dan-Dan2,3; Ta-La, A.1; Wang, Song1; Zhao, Rong-Sheng3; Nie, Hong-Gang4; Zhang, Ai-Hua1; Wang, Tao1; Fan, Min-Hua1
关键词Chronic kidney disease HPLC-ESI-MS/MS metabolomics urinary phospholipids
刊名BIOMARKERS
2013-11-01
DOI10.3109/1354750X.2013.837100
18期:7页:601-606
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]CHRONIC-RENAL-FAILURE ; MASS-SPECTROMETRY ; CHROMATOGRAPHY ; METABONOMICS ; INJURY ; QUANTIFICATION ; IDENTIFICATION ; IONIZATION ; BIOMARKERS ; OBESITY
英文摘要

Objective: To evaluate whether urinary phospholipids could be regarded as biomarkers of chronic kidney disease.

Materials and methods: Thirteen healthy volunteers and 26 consecutive chronic kidney disease patients were included. Urinary phospholipids were quantified by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Results: Urinary phosphatidylcholines concentrations (PC 16:0/16:0, 16:0/22:3, 16:0/18:1 and 16:0/18:2) were significantly higher both in glomerulonephritis group (all p<0.001) and in tubulointerstitial injury group (all p < 0.05) than in healthy control group. Meanwhile, sphingomyelin concentrations (SM 18:1/16:0 and 18:1/18:0) in glomerulonephritis group were significantly higher than those in healthy control group (all p<0.001). Urinary PCs and SMs were positively correlated with proteinuria but negatively correlated with serum albumin. Meanwhile, PCs were positively correlated with serum creatinine.

Conclusion: Our work first demonstrated that urinary phospholipids might be biomarkers for the chronic kidney disease patients. Increased urinary phospholipids in chronic kidney disease patients might result from proteinuria, damaged kidney function or proteinuria induced hypoalbuminemia or lipotoxicity.

语种英语
WOS记录号WOS:000326909900008
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58209
Collection北京大学第三临床医学院_肾内科
北京大学公共卫生学院_公共卫生学院
北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Inst Analyt Chem, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Yang, Wen-Ling,Bai, Qiong,Li, Dan-Dan,et al. Changes of urinary phospholipids in the chronic kidney disease patients[J]. BIOMARKERS,2013,18(7):601-606.
APA Yang, Wen-Ling.,Bai, Qiong.,Li, Dan-Dan.,Ta-La, A..,Wang, Song.,...&Fan, Min-Hua.(2013).Changes of urinary phospholipids in the chronic kidney disease patients.BIOMARKERS,18(7),601-606.
MLA Yang, Wen-Ling,et al."Changes of urinary phospholipids in the chronic kidney disease patients".BIOMARKERS 18.7(2013):601-606.
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