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学科主题临床医学
Changes of urinary phospholipids in the chronic kidney disease patients
Yang, Wen-Ling1; Bai, Qiong1; Li, Dan-Dan2,3; Ta-La, A.1; Wang, Song1; Zhao, Rong-Sheng3; Nie, Hong-Gang4; Zhang, Ai-Hua1; Wang, Tao1; Fan, Min-Hua1
关键词Chronic kidney disease HPLC-ESI-MS/MS metabolomics urinary phospholipids
刊名BIOMARKERS
2013-11-01
DOI10.3109/1354750X.2013.837100
18期:7页:601-606
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
资助者National Natural Science Foundation of China, People&prime ; s Republic of China ; National Natural Science Foundation of China, People&prime ; s Republic of China
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]CHRONIC-RENAL-FAILURE ; MASS-SPECTROMETRY ; CHROMATOGRAPHY ; METABONOMICS ; INJURY ; QUANTIFICATION ; IDENTIFICATION ; IONIZATION ; BIOMARKERS ; OBESITY
英文摘要

Objective: To evaluate whether urinary phospholipids could be regarded as biomarkers of chronic kidney disease.

Materials and methods: Thirteen healthy volunteers and 26 consecutive chronic kidney disease patients were included. Urinary phospholipids were quantified by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Results: Urinary phosphatidylcholines concentrations (PC 16:0/16:0, 16:0/22:3, 16:0/18:1 and 16:0/18:2) were significantly higher both in glomerulonephritis group (all p<0.001) and in tubulointerstitial injury group (all p < 0.05) than in healthy control group. Meanwhile, sphingomyelin concentrations (SM 18:1/16:0 and 18:1/18:0) in glomerulonephritis group were significantly higher than those in healthy control group (all p<0.001). Urinary PCs and SMs were positively correlated with proteinuria but negatively correlated with serum albumin. Meanwhile, PCs were positively correlated with serum creatinine.

Conclusion: Our work first demonstrated that urinary phospholipids might be biomarkers for the chronic kidney disease patients. Increased urinary phospholipids in chronic kidney disease patients might result from proteinuria, damaged kidney function or proteinuria induced hypoalbuminemia or lipotoxicity.

语种英语
所属项目编号81170706
资助者National Natural Science Foundation of China, People&prime ; s Republic of China ; National Natural Science Foundation of China, People&prime ; s Republic of China
WOS记录号WOS:000326909900008
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58209
专题北京大学第三临床医学院_肾内科
作者单位1.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Inst Analyt Chem, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Wen-Ling,Bai, Qiong,Li, Dan-Dan,et al. Changes of urinary phospholipids in the chronic kidney disease patients[J]. BIOMARKERS,2013,18(7):601-606.
APA Yang, Wen-Ling.,Bai, Qiong.,Li, Dan-Dan.,Ta-La, A..,Wang, Song.,...&Fan, Min-Hua.(2013).Changes of urinary phospholipids in the chronic kidney disease patients.BIOMARKERS,18(7),601-606.
MLA Yang, Wen-Ling,et al."Changes of urinary phospholipids in the chronic kidney disease patients".BIOMARKERS 18.7(2013):601-606.
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