北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
The Fangshan/family-based ischemic stroke study in China (FISSIC) protocol
作者: Tang, Xun; Hu, Yonghua; Chen, Dafang; Zhan, Siyan; Zhang, Zongxin; Dou, Huidong
刊名: BMC MEDICAL GENETICS
发表日期: 2007-09-10
DOI: 10.1186/1471-2350-8-60
卷: 8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: MULTIFACTOR-DIMENSIONALITY REDUCTION ; FAMILY-BASED TESTS ; METHODOLOGICAL ISSUES ; GENETIC ASSOCIATION ; LINKAGE ; RISK ; QUESTIONNAIRE ; GENOTYPES ; SUBTYPES ; HISTORY
英文摘要:

Background: The exact etiology of ischemic stroke remains unclear, because multiple genetic predispositions and environmental risk factors may be involved, and their interactions dictate the complexity. Family-based studies provide unique features in design, while they are currently underrepresented for studies of ischemic stroke in developing countries. The Fangshan/Family-based Ischemic Stroke Study In China (FISSIC) program aims to conduct a genetic pedigree study of ischemic stroke in rural communities of China.

Methods/Design: The pedigrees of ischemic stroke with clear documentation are recruited by using the proband-initiated contact method, based on the stroke registry in hospital and communities. Blood samples and detailed information of pedigrees are collected through the health care network in the rural area, and prospective follow-up of the pedigrees cohort is scheduled. Complementary strategies of both family-based design and matched case-spousal control design are used, and comprehensive statistical methods will be implemented to ascertain potential complex genetic and environmental factors and their interactions as well.

Discussion: This study is complementary to other genetic pedigree studies of ischemic stroke, such as the Siblings With Ischemic Stroke Study (SWISS), which are established in developed countries. We describe the protocol of this family-based genetic epidemiological study that may be used as a new practical guideline and research paradigm in developing countries and facilitate initiatives of stroke study for international collaborations.

语种: 英语
WOS记录号: WOS:000250034100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58217
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Minist Educ, Key Lab Epidemiol, Beijing 100083, Peoples R China
2.First Hosp Fangshan Dist, Dept Neurol, Beijing 102400, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
4.First Hosp Fangshan Dist, Dept Clin Lab Med, Beijing 102400, Peoples R China

Recommended Citation:
Tang, Xun,Hu, Yonghua,Chen, Dafang,et al. The Fangshan/family-based ischemic stroke study in China (FISSIC) protocol[J]. BMC MEDICAL GENETICS,2007,8.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tang, Xun]'s Articles
[Hu, Yonghua]'s Articles
[Chen, Dafang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tang, Xun]‘s Articles
[Hu, Yonghua]‘s Articles
[Chen, Dafang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace