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学科主题: 药学
题名:
Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson′s Disease
作者: Li, Shen1,2; Pu, Xiao-Ping1,2
关键词: kaempferol ; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; neuroprotection ; oxidative stress ; Parkinson&prime ; s disease
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2011-08-01
卷: 34, 期:8, 页:1291-1296
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: LOW-DENSITY-LIPOPROTEIN ; OXIDATIVE STRESS ; MPTP MODEL ; DOPAMINERGIC NEUROTOXICITY ; MONOAMINE-OXIDASE ; CELL-DEATH ; NEURONS ; 6-HYDROXYDOPAMINE ; MECHANISMS ; RATS
英文摘要:

In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson′s disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity, and the elevation of malondialdehyde (MDA) levels in the substantia nigra. When administered prior to MPTP, kaempferol improved motor coordination, raised striatal dopamine and its metabolite levels, increased SOD and GSH-PX activity, and reduced the content of MDA compared with mice treated with MPTP alone. Immunohistochemical studies using anti-tyrosine hydroxylase (TH) antibody showed that medication of kaempferol could prevent the loss of TH-positive neurons induced by MPTP. Taken together, we propose that kaempferol has shown anti-parkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action.

语种: 英语
所属项目编号: 30973889
项目资助者: National Natural Science of China
WOS记录号: WOS:000294513000024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58218
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Li, Shen,Pu, Xiao-Ping. Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson′s Disease[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2011,34(8):1291-1296.
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