IR@PKUHSC  > 北京大学药学院
学科主题药学
Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson′s Disease
Li, Shen1,2; Pu, Xiao-Ping1,2
关键词kaempferol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neuroprotection oxidative stress Parkinson&prime s disease
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2011-08-01
34期:8页:1291-1296
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]LOW-DENSITY-LIPOPROTEIN ; OXIDATIVE STRESS ; MPTP MODEL ; DOPAMINERGIC NEUROTOXICITY ; MONOAMINE-OXIDASE ; CELL-DEATH ; NEURONS ; 6-HYDROXYDOPAMINE ; MECHANISMS ; RATS
英文摘要

In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson′s disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity, and the elevation of malondialdehyde (MDA) levels in the substantia nigra. When administered prior to MPTP, kaempferol improved motor coordination, raised striatal dopamine and its metabolite levels, increased SOD and GSH-PX activity, and reduced the content of MDA compared with mice treated with MPTP alone. Immunohistochemical studies using anti-tyrosine hydroxylase (TH) antibody showed that medication of kaempferol could prevent the loss of TH-positive neurons induced by MPTP. Taken together, we propose that kaempferol has shown anti-parkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action.

语种英语
WOS记录号WOS:000294513000024
项目编号30973889
资助机构National Natural Science of China
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58218
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
北京大学第二临床医学院_国际合作办公室
作者单位1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Shen,Pu, Xiao-Ping. Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson′s Disease[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2011,34(8):1291-1296.
APA Li, Shen,&Pu, Xiao-Ping.(2011).Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson′s Disease.BIOLOGICAL & PHARMACEUTICAL BULLETIN,34(8),1291-1296.
MLA Li, Shen,et al."Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson′s Disease".BIOLOGICAL & PHARMACEUTICAL BULLETIN 34.8(2011):1291-1296.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Shen]的文章
[Pu, Xiao-Ping]的文章
百度学术
百度学术中相似的文章
[Li, Shen]的文章
[Pu, Xiao-Ping]的文章
必应学术
必应学术中相似的文章
[Li, Shen]的文章
[Pu, Xiao-Ping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。