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Induction of human promyelocytic into monocytes by arsenic leukemia HL-60 cell differentiation sulphide: Involvement of serine/threonine protein phosphatases
Luo, Li-Yun; Huang, Jian; Gou, Bao-Di; Zhang, Tian-Lan; Wang, Kui
关键词arsenic sulfide realgar monocytic differentiation protein phosphatase HL-60
刊名LEUKEMIA RESEARCH
2006-11-01
DOI10.1016/j.leukres.2006.03.016
30期:11页:1399-1405
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]INDUCED GRANULOCYTIC DIFFERENTIATION ; TRANS-RETINOIC ACID ; SIGNAL-TRANSDUCTION ; HL60 CELLS ; LINE HL-60 ; KINASE-C ; TRIOXIDE ; EXPRESSION ; PROLIFERATION ; INHIBITORS
英文摘要

The clinical efficacy of arsenic sulfide (As4S4), also known as realgar, in the treatment of leukemia in China is prompting people to explore the underlying mechanism. We examined the realgar-induced differentiation in human promyelocytic leukemia cell line HL-60. Cells exhibited proliferation inhibition when treated with 0.10-1.5 mu M of realgar, and underwent monocytic differentiation as indicated by morphological changes, NBT reduction assay, and cytofluorometric analyses of the cell surface antigens, CD11b and CD14. Accompanying the differentiation, the activity of serine/threonine protein phosphatase type 1 (PP1) and type 2A (MA) were enhanced, whereas the activity of PP2B remained virtually the same compared to the control. When cells were treated with realgar in the presence of an inhibitor of PP1 and 2A or an inhibitor of PP2B, the differentiation of the cells was partially suppressed as revealed by NBT reduction assay and the expression of CD14. Our data demonstrate that realgar induces monocytic differentiation in HL-60 cells and that some serine/threonine protein phosphatases may be involved in the process. (c) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000241346600012
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58222
专题北京大学药学院_化学生物学系
作者单位1.Capital Univ Med Sci, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100069, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
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Luo, Li-Yun,Huang, Jian,Gou, Bao-Di,et al. Induction of human promyelocytic into monocytes by arsenic leukemia HL-60 cell differentiation sulphide: Involvement of serine/threonine protein phosphatases[J]. LEUKEMIA RESEARCH,2006,30(11):1399-1405.
APA Luo, Li-Yun,Huang, Jian,Gou, Bao-Di,Zhang, Tian-Lan,&Wang, Kui.(2006).Induction of human promyelocytic into monocytes by arsenic leukemia HL-60 cell differentiation sulphide: Involvement of serine/threonine protein phosphatases.LEUKEMIA RESEARCH,30(11),1399-1405.
MLA Luo, Li-Yun,et al."Induction of human promyelocytic into monocytes by arsenic leukemia HL-60 cell differentiation sulphide: Involvement of serine/threonine protein phosphatases".LEUKEMIA RESEARCH 30.11(2006):1399-1405.
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