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学科主题临床医学
Predictors for Mortality in Patients with Antineutrophil Cytoplasmic Autoantibody-associated Vasculitis: A Study of 398 Chinese Patients
Lai, Qing-ying1; Ma, Tian-Tian1; Li, Zhi-ying1; Chang, Dong-yuan1; Zhao, Ming-Hui1; Chen, Min1
关键词ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY VASCULITIS MORTALITY PREDICTORS SECONDARY INFECTION
刊名JOURNAL OF RHEUMATOLOGY
2014-09-01
DOI10.3899/jrheum.131426
41期:9页:1849-1855
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]CHURG-STRAUSS-SYNDROME ; ANCA-ASSOCIATED VASCULITIS ; MICROSCOPIC POLYANGIITIS ; WEGENERS-GRANULOMATOSIS ; OLDER PATIENTS ; POLYARTERITIS-NODOSA ; RENAL VASCULITIS ; GLOMERULONEPHRITIS ; THERAPY ; TIME
英文摘要

Objective. Patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) have high mortality despite the introduction of immunosuppressive therapy. We investigated factors associated with mortality of patients with AAV in a single Chinese cohort.

Methods. A total of 398 consecutive patients with AAV diagnosed in our center were recruited. Clinical and laboratory data were collected retrospectively. The predictive values of variables associated with mortality were analyzed.

Results. During followup of a median duration 25.5 months (range 1-196 mo), 135 out of 398 patients (33.9%) died, with 83 deaths within the first 12 months after diagnosis. Independent predictors of all-cause mortality were age (p < 0.001), secondary infection (p < 0.001), pulmonary involvement of AAV (p = 0.012), and initial renal function (p = 0.001). Secondary infection was the leading cause of death (53/153, 39.3%) during the first year after diagnosis, while cardiovascular event was the leading cause of death (15/53, 28.8%) after 12 months from diagnosis. Independent predictors of secondary infection were age (p = 0.002), initial renal function (p = 0.041), lymphocyte counts in the peripheral blood (p = 0.03), and underlying pulmonary involvement of AAV (p = 0.001).

Conclusion. Secondary infection is the overall leading cause and independent predictor of death in patients diagnosed with AAV. Cardiovascular event is a major cause of death during the late followup. Prudent monitoring should be given to patients of advancing age with renal dysfunction to reduce adverse events, especially infectious complications.

语种英语
WOS记录号WOS:000341825100019
项目编号2012CB517700 ; 81370829 ; 81321064 ; 20120001110018 ; 2011BAI10B04
资助机构Chinese 973 project ; National Natural Science Fund ; Research Fund for the Doctoral Program of Higher Education of China ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58224
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Lai, Qing-ying,Ma, Tian-Tian,Li, Zhi-ying,et al. Predictors for Mortality in Patients with Antineutrophil Cytoplasmic Autoantibody-associated Vasculitis: A Study of 398 Chinese Patients[J]. JOURNAL OF RHEUMATOLOGY,2014,41(9):1849-1855.
APA Lai, Qing-ying,Ma, Tian-Tian,Li, Zhi-ying,Chang, Dong-yuan,Zhao, Ming-Hui,&Chen, Min.(2014).Predictors for Mortality in Patients with Antineutrophil Cytoplasmic Autoantibody-associated Vasculitis: A Study of 398 Chinese Patients.JOURNAL OF RHEUMATOLOGY,41(9),1849-1855.
MLA Lai, Qing-ying,et al."Predictors for Mortality in Patients with Antineutrophil Cytoplasmic Autoantibody-associated Vasculitis: A Study of 398 Chinese Patients".JOURNAL OF RHEUMATOLOGY 41.9(2014):1849-1855.
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