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学科主题: 药学
题名:
Effects on the bones of vanadyl acetylacetonate by oral administration: a comparison study in diabetic rats
作者: Zhang, Shuang-Qing; Chen, Guo-Hua; Lu, Wan-Liang; Zhang, Qiang
关键词: vanadyl acetylacetonate ; diabetes ; bone markers ; bone biomechanics ; bone histomorphometry
刊名: JOURNAL OF BONE AND MINERAL METABOLISM
发表日期: 2007-09-01
DOI: 10.1007/s00774-007-0759-7
卷: 25, 期:5, 页:293-301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Medicine, Research & Experimental
研究领域[WOS]: Endocrinology & Metabolism ; Research & Experimental Medicine
关键词[WOS]: PHOSPHATASE-ACTIVITY ; OVARIECTOMIZED RATS ; MINERAL DENSITY ; WISTAR RATS ; FEMALE RATS ; IN-VIVO ; INSULIN ; MELLITUS ; METABOLISM ; OSTEOBLAST
英文摘要:

Oral delivery, rather than parenteral administration, would be beneficial for treating diabetic mellitus owing to the need for a long-term regimen. The objectives of this study were to evaluate oral delivery tolerance and the effects on the bone of accumulated vanadium following the long-term administration of vanadyl acetylacetonate (VAC). Normal and diabetic rats were intragastrically administered VAC at a dose of 3mg vanadium/kg body weight once daily for 35 consecutive days. VAC did not cause any obvious signs of diarrhea, any changes in kidney or liver, or deaths in any group. The phosphate levels in the bone were slightly increased, and the calcium levels in the bone were not obviously changed as compared with those of the rat group not receiving VAC. After administration of VAC, the decreased ultimate strength, trabecular thickness, mineral apposition rate, and plasma osteocalcin in diabetic rats were either improved or normalized, but reduced bone mineral density (BMD) in diabetic rats was not improved. None of the parameters evaluated in normal rats were altered. The results indicate that the oral VAC is tolerated and benefits the diabetic osteopathy of rats, but seems not to influence the bone of normal rats. They also suggest that VAC improves diabetes-related bone disorders, primarily by improving the diabetic state.

语种: 英语
WOS记录号: WOS:000248903000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58231
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Chinese Acad Agr Sci, Inst Vegetales & Flowers, Beijing, Peoples R China

Recommended Citation:
Zhang, Shuang-Qing,Chen, Guo-Hua,Lu, Wan-Liang,et al. Effects on the bones of vanadyl acetylacetonate by oral administration: a comparison study in diabetic rats[J]. JOURNAL OF BONE AND MINERAL METABOLISM,2007,25(5):293-301.
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