IR@PKUHSC  > 北京大学药学院
学科主题药学
Total Synthesis of (-)-Goniomitine
Zhou, Shiqiang1; Jia, Yanxing1,2
刊名ORGANIC LETTERS
2014-06-20
DOI10.1021/ol501341b
16期:12页:3416-3418
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET
研究领域[WOS]Chemistry
关键词[WOS]CATALYTIC ENANTIOSELECTIVE CONSTRUCTION ; CARBON QUATERNARY STEREOCENTERS ; ROOM-TEMPERATURE ; ALPHA-ALKYLATION ; BORYLATION ; (+/-)-GONIOMITINE ; HETEROARENES ; COMPLEXES ; ESTERS ; ACID
英文摘要

The total synthesis of (-)-goniomitine has been accomplished in 11 steps starting from commercially available diethyl L-malate. The synthesis features a chiral pool approach to prepare the chiral C-9 unit containing a quaternary carbon center, an Ir-catalyzed C-H borylation to synthesize the 2-indoleboronic acid pinacol ester, and a Suzuki reaction to couple together the two key intermediates. Notably, the high degree of convergence of this strategy makes it particularly amenable to the total synthesis of other aspidosperma family natural products.

语种英语
所属项目编号21372017 ; 21290183 ; 2010CB833200
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET
WOS记录号WOS:000337869800062
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58233
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Shiqiang,Jia, Yanxing. Total Synthesis of (-)-Goniomitine[J]. ORGANIC LETTERS,2014,16(12):3416-3418.
APA Zhou, Shiqiang,&Jia, Yanxing.(2014).Total Synthesis of (-)-Goniomitine.ORGANIC LETTERS,16(12),3416-3418.
MLA Zhou, Shiqiang,et al."Total Synthesis of (-)-Goniomitine".ORGANIC LETTERS 16.12(2014):3416-3418.
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