北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Total Synthesis of (-)-Goniomitine
作者: Zhou, Shiqiang1; Jia, Yanxing1,2
刊名: ORGANIC LETTERS
发表日期: 2014-06-20
DOI: 10.1021/ol501341b
卷: 16, 期:12, 页:3416-3418
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: CATALYTIC ENANTIOSELECTIVE CONSTRUCTION ; CARBON QUATERNARY STEREOCENTERS ; ROOM-TEMPERATURE ; ALPHA-ALKYLATION ; BORYLATION ; (+/-)-GONIOMITINE ; HETEROARENES ; COMPLEXES ; ESTERS ; ACID
英文摘要:

The total synthesis of (-)-goniomitine has been accomplished in 11 steps starting from commercially available diethyl L-malate. The synthesis features a chiral pool approach to prepare the chiral C-9 unit containing a quaternary carbon center, an Ir-catalyzed C-H borylation to synthesize the 2-indoleboronic acid pinacol ester, and a Suzuki reaction to couple together the two key intermediates. Notably, the high degree of convergence of this strategy makes it particularly amenable to the total synthesis of other aspidosperma family natural products.

语种: 英语
所属项目编号: 21372017 ; 21290183 ; 2010CB833200
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET
WOS记录号: WOS:000337869800062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58233
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

Recommended Citation:
Zhou, Shiqiang,Jia, Yanxing. Total Synthesis of (-)-Goniomitine[J]. ORGANIC LETTERS,2014,16(12):3416-3418.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Shiqiang]'s Articles
[Jia, Yanxing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Shiqiang]‘s Articles
[Jia, Yanxing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace