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学科主题临床医学
MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
Jiang, Ping1; Rao, En Y.2; Meng, Na1; Zhao, Yong2; Wang, Jun J.1
刊名RADIATION ONCOLOGY
2010-11-01
DOI10.1186/1748-717X-5-100
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]GENE-EXPRESSION ; SUPPRESSION ; SIGNATURE ; PATHWAY ; MICE
英文摘要

The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic.

语种英语
WOS记录号WOS:000284267100001
项目编号[2007]8
资助机构Ministry of Civil Affair, China
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58240
专题北京大学第三临床医学院_肿瘤放疗科
作者单位1.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing 100101, Peoples R China
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GB/T 7714
Jiang, Ping,Rao, En Y.,Meng, Na,et al. MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells[J]. RADIATION ONCOLOGY,2010,5.
APA Jiang, Ping,Rao, En Y.,Meng, Na,Zhao, Yong,&Wang, Jun J..(2010).MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells.RADIATION ONCOLOGY,5.
MLA Jiang, Ping,et al."MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells".RADIATION ONCOLOGY 5(2010).
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