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学科主题: 临床医学
题名:
MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
作者: Jiang, Ping1; Rao, En Y.2; Meng, Na1; Zhao, Yong2; Wang, Jun J.1
刊名: RADIATION ONCOLOGY
发表日期: 2010-11-01
DOI: 10.1186/1748-717X-5-100
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: GENE-EXPRESSION ; SUPPRESSION ; SIGNATURE ; PATHWAY ; MICE
英文摘要:

The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic.

语种: 英语
所属项目编号: [2007]8
项目资助者: Ministry of Civil Affair, China
WOS记录号: WOS:000284267100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58240
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing 100101, Peoples R China

Recommended Citation:
Jiang, Ping,Rao, En Y.,Meng, Na,et al. MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells[J]. RADIATION ONCOLOGY,2010,5.
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