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学科主题: 临床医学
题名:
Diagnosis and multi-disciplinary management of hepatic metastases from gastrointestinal stromal tumour (GIST)
作者: Ye, Ying-jiang1; Gao, Zhi-dong1; Poston, G. J.2; Wang, Shan1
关键词: Diagnosis ; Management ; Gastrointestinal stromal tumour ; Hepatic metastasis
刊名: EJSO
发表日期: 2009-08-01
DOI: 10.1016/j.ejso.2009.01.003
卷: 35, 期:8, 页:787-792
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: POSITRON-EMISSION-TOMOGRAPHY ; SINGLE-CENTER EXPERIENCE ; TERM-FOLLOW-UP ; IMATINIB MESYLATE ; C-KIT ; PROGNOSTIC-FACTORS ; HEPATOCELLULAR-CARCINOMA ; LIVER-TRANSPLANTATION ; SURGICAL RESECTION ; CONSENSUS APPROACH
英文摘要:

Aim: To explore the present application of diagnosis and management of hepatic metastases from GIST.

Methods: We performed a systematic review of the literature for Studies concerning hepatic metastases from GIST. A literature search was performed using the Medline/PubMed databases to identify publications relevant to the review published front January 1998 to December 2008. Totally 113 relevant articles were retrieved. Abstracts from recent ASCO symposia were hand searched for relevant articles. After the primary filtration, articles oil review and with repetitive content were excluded. The articles on clinical research, which were issued ill authorized journals, were selected. At last, totally 69 articles were included for review.

Findings: The rate of liver metastases was reported as 15.9% in primary GISTs. The recurrence rate following surgical resection for hepatic metastases from GIST had been reported as 70-77%. For metastatic GIST patients with tyrosine kinase inhibitor (TKI) treatment, it demonstrated rates of CR, PR and SD respectively of 5.84%, 50.7%, and 32.4%. Combining, repeated surgery with TKI treatment. R0/R1 resection rates range in various series between 48 and 82%. For those patients with unresectable disease confined to the liver or unable to tolerate liver resection due to co-morbidity or advanced age, RFA, HACE, TKI therapy. or even liver transplantation. call also improve survival.

Conclusions: The liver is a common metastatic site for gastrointestinal stromal tumour (GIST). Appropriate initial evaluation remains paramount for selecting the correct management strategy. Multi-disciplinary management (Which includes pathology. medical oncology surgical oncology, and imaging expertise) of this disease is important for both curative and palliative treatment in these patients. Combining repeated surgery with TKI treatment may be the most effective management for GIST patients with liver metastases. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000268439200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58246
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: 1.Peking Univ, Dept Surg Gastroenterol, Peoples Hosp, Beijing 100044, Peoples R China
2.Aintree Univ Hosp NHS Fdn Trust, Dept Surg, Liverpool L9 7AL, Merseyside, England

Recommended Citation:
Ye, Ying-jiang,Gao, Zhi-dong,Poston, G. J.,et al. Diagnosis and multi-disciplinary management of hepatic metastases from gastrointestinal stromal tumour (GIST)[J]. EJSO,2009,35(8):787-792.
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