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学科主题临床医学
Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease
Chang, Chun; Yao, Wanzhen
关键词Quality of Life Inflammation Pulmonary Disease, Chronic Obstructive
刊名MEDICAL SCIENCE MONITOR
2014-02-25
20页:311-320
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者Special Fund of the Chinese Medical Association for scientific research in chronic respiratory tract diseases ; Special Fund of the Chinese Medical Association for scientific research in chronic respiratory tract diseases
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]AIRWAY INFLAMMATION ; COPD EXACERBATIONS ; INDUCED SPUTUM ; LUNG-FUNCTION ; SYSTEMIC INFLAMMATION ; ANTIBIOTIC-THERAPY ; RISK-FACTORS ; DECLINE ; INFECTIONS ; RECOVERY
英文摘要

Background: When exacerbation of chronic obstructive pulmonary disease (AECOPD) occurs frequently, patients have high levels of airway and systemic inflammation and a poor quality of life. This study compared the nature and course of systemic and airway inflammation during AECOPD between patients who experienced frequent exacerbations and those with non-frequent exacerbations.

Material/Methods: Consecutive hospitalized patients with AECOPD were recruited and divided into 2 groups according to the frequency of AECOPD they had experienced in the previous year. Frequent exacerbators (defined as 2 or more AECOPD in the previous year) and non-frequent exacerbators (defined as zero or 1 AECOPD in the previous year). Inflammatory (interleukin 6, interleukin 8, myeloperoxidase, and C-reactive protein) and clinical (dyspnea, COPD assessment test (CAT), and peak expiratory flow) indices were assessed on the day of admission before starting therapy, day 7 of treatment, the day of planned discharge (day 10-14), and 8 weeks after discharge.

Results: We analyzed data from 135 patients; 78 (57.8%) were non-frequent exacerbators and 57 (42.2%) were frequent exacerbators. In both groups, the inflammatory and clinical indices at day 7, the day of planned discharge (day 10-14), and 8 weeks were significantly improved compared to those at admission. Frequent exacerbators had a smaller reduction in their inflammatory indices and CAT scores between exacerbation onset and all the other time points compared with infrequent exacerbators.

Conclusions: Frequent exacerbators have a reduced response to treatment of AECOPD in terms of inflammatory indices and quality of life.

语种英语
所属项目编号07010440052
资助者Special Fund of the Chinese Medical Association for scientific research in chronic respiratory tract diseases ; Special Fund of the Chinese Medical Association for scientific research in chronic respiratory tract diseases
WOS记录号WOS:000332005400001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58247
专题北京大学第三临床医学院_呼吸科
作者单位Peking Univ, Dept Resp Med, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chang, Chun,Yao, Wanzhen. Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease[J]. MEDICAL SCIENCE MONITOR,2014,20:311-320.
APA Chang, Chun,&Yao, Wanzhen.(2014).Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease.MEDICAL SCIENCE MONITOR,20,311-320.
MLA Chang, Chun,et al."Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease".MEDICAL SCIENCE MONITOR 20(2014):311-320.
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