|Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease|
|Chang, Chun; Yao, Wanzhen|
|关键词||Quality of Life Inflammation Pulmonary Disease, Chronic Obstructive|
|刊名||MEDICAL SCIENCE MONITOR|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, Research & Experimental|
|研究领域[WOS]||Research & Experimental Medicine|
|关键词[WOS]||AIRWAY INFLAMMATION ; COPD EXACERBATIONS ; INDUCED SPUTUM ; LUNG-FUNCTION ; SYSTEMIC INFLAMMATION ; ANTIBIOTIC-THERAPY ; RISK-FACTORS ; DECLINE ; INFECTIONS ; RECOVERY|
Background: When exacerbation of chronic obstructive pulmonary disease (AECOPD) occurs frequently, patients have high levels of airway and systemic inflammation and a poor quality of life. This study compared the nature and course of systemic and airway inflammation during AECOPD between patients who experienced frequent exacerbations and those with non-frequent exacerbations.
Material/Methods: Consecutive hospitalized patients with AECOPD were recruited and divided into 2 groups according to the frequency of AECOPD they had experienced in the previous year. Frequent exacerbators (defined as 2 or more AECOPD in the previous year) and non-frequent exacerbators (defined as zero or 1 AECOPD in the previous year). Inflammatory (interleukin 6, interleukin 8, myeloperoxidase, and C-reactive protein) and clinical (dyspnea, COPD assessment test (CAT), and peak expiratory flow) indices were assessed on the day of admission before starting therapy, day 7 of treatment, the day of planned discharge (day 10-14), and 8 weeks after discharge.
Results: We analyzed data from 135 patients; 78 (57.8%) were non-frequent exacerbators and 57 (42.2%) were frequent exacerbators. In both groups, the inflammatory and clinical indices at day 7, the day of planned discharge (day 10-14), and 8 weeks were significantly improved compared to those at admission. Frequent exacerbators had a smaller reduction in their inflammatory indices and CAT scores between exacerbation onset and all the other time points compared with infrequent exacerbators.
Conclusions: Frequent exacerbators have a reduced response to treatment of AECOPD in terms of inflammatory indices and quality of life.
|资助机构||Special Fund of the Chinese Medical Association for scientific research in chronic respiratory tract diseases|
|作者单位||Peking Univ, Dept Resp Med, Hosp 3, Beijing 100871, Peoples R China|
|Chang, Chun,Yao, Wanzhen. Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease[J]. MEDICAL SCIENCE MONITOR,2014,20:311-320.|
|APA||Chang, Chun,&Yao, Wanzhen.(2014).Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease.MEDICAL SCIENCE MONITOR,20,311-320.|
|MLA||Chang, Chun,et al."Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease".MEDICAL SCIENCE MONITOR 20(2014):311-320.|