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Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease
Chang, Chun; Yao, Wanzhen
关键词Quality of Life Inflammation Pulmonary Disease, Chronic Obstructive
刊名MEDICAL SCIENCE MONITOR
2014-02-25
20页:311-320
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]AIRWAY INFLAMMATION ; COPD EXACERBATIONS ; INDUCED SPUTUM ; LUNG-FUNCTION ; SYSTEMIC INFLAMMATION ; ANTIBIOTIC-THERAPY ; RISK-FACTORS ; DECLINE ; INFECTIONS ; RECOVERY
英文摘要

Background: When exacerbation of chronic obstructive pulmonary disease (AECOPD) occurs frequently, patients have high levels of airway and systemic inflammation and a poor quality of life. This study compared the nature and course of systemic and airway inflammation during AECOPD between patients who experienced frequent exacerbations and those with non-frequent exacerbations.

Material/Methods: Consecutive hospitalized patients with AECOPD were recruited and divided into 2 groups according to the frequency of AECOPD they had experienced in the previous year. Frequent exacerbators (defined as 2 or more AECOPD in the previous year) and non-frequent exacerbators (defined as zero or 1 AECOPD in the previous year). Inflammatory (interleukin 6, interleukin 8, myeloperoxidase, and C-reactive protein) and clinical (dyspnea, COPD assessment test (CAT), and peak expiratory flow) indices were assessed on the day of admission before starting therapy, day 7 of treatment, the day of planned discharge (day 10-14), and 8 weeks after discharge.

Results: We analyzed data from 135 patients; 78 (57.8%) were non-frequent exacerbators and 57 (42.2%) were frequent exacerbators. In both groups, the inflammatory and clinical indices at day 7, the day of planned discharge (day 10-14), and 8 weeks were significantly improved compared to those at admission. Frequent exacerbators had a smaller reduction in their inflammatory indices and CAT scores between exacerbation onset and all the other time points compared with infrequent exacerbators.

Conclusions: Frequent exacerbators have a reduced response to treatment of AECOPD in terms of inflammatory indices and quality of life.

语种英语
WOS记录号WOS:000332005400001
项目编号07010440052
资助机构Special Fund of the Chinese Medical Association for scientific research in chronic respiratory tract diseases
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58247
专题北京大学第三临床医学院_呼吸科
北京大学第三临床医学院_运动医学研究所
作者单位Peking Univ, Dept Resp Med, Hosp 3, Beijing 100871, Peoples R China
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GB/T 7714
Chang, Chun,Yao, Wanzhen. Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease[J]. MEDICAL SCIENCE MONITOR,2014,20:311-320.
APA Chang, Chun,&Yao, Wanzhen.(2014).Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease.MEDICAL SCIENCE MONITOR,20,311-320.
MLA Chang, Chun,et al."Time course of inflammation resolution in patients with frequent exacerbations of chronic obstructive pulmonary disease".MEDICAL SCIENCE MONITOR 20(2014):311-320.
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