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学科主题: 临床医学
题名:
Low Intraprostatic DHT Promotes the Infiltration of CD8+ T Cells in BPH Tissues via Modulation of CCL5 Secretion
作者: Fan, Yu1,2,3; Hu, Shuai1,2,3; Liu, Jie1,2,3; Xiao, Fei4; Li, Xin1,2,3; Yu, Wei1,2,3; Cui, Yun1,2,3; Sun, Mengkui1,2,3; Lv, Tianjing1,2,3; He, Qun1,2,3; Jin, Jie1,2,3
刊名: MEDIATORS OF INFLAMMATION
发表日期: 2014
DOI: 10.1155/2014/397815
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: BENIGN PROSTATIC HYPERPLASIA ; 5-ALPHA-REDUCTASE INHIBITORS ; CHRONIC INFLAMMATION ; EXPRESSION ; PATHOGENESIS ; RECEPTORS ; CANCER ; IDENTIFICATION ; LYMPHOCYTES ; FINASTERIDE
英文摘要:

Clinical studies suggested thatandrogen might be associated with infiltrating T cells in prostate of benign prostatic hyperplasia (BPH) patients, but detail of Tcell subset and mechanism still remained unclear. The present study tested the hypothesis that intraprostatic 5 alpha-dihydrotestosterone (DHT) exerts effects on T cells recruitment by BPH epithelial cells. Prostate tissues from 64 cases of BPH patients after transurethral resection of prostate (TURP) were divided into 2 groups: (1) no medication history; (2) administration of 5 alpha-reductase type II inhibitorfinasteride 5 mg daily for at least 6 months before surgery. Group 2 presented significantly higher CD8+ T cells infiltration than group 1, but no changes in CD4+ T cells (immunohistochemistry and flow cytometry). In vitro study more CD8+ T cell migrated to the prostate tissue lysates from group 2 and BPH1 cells in low DHT condition. Transcription of chemokine (C-C motif) Ligand 5 (CCL5) mRNA in BPH-1 cells and chemokine (C-C motif) receptor 5 (CCR5) mRNA in CD8+ T cells were upregulated in low DHT condition (q-PCR). CCL5 expression was also identified to be higher in group 2 prostate tissues by IHC. This study suggested that intraprostatic DHT may participate in regulating inflammatory response which was induced by human prostatic epithelial cell, via modulating CCL5 secretion.

语种: 英语
所属项目编号: 81370858
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000334760000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58248
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.China Japanese Friendship Hosp, Dept Surg, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
3.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
4.Natl Res Ctr Genitourinary Oncol, Beijing, Peoples R China

Recommended Citation:
Fan, Yu,Hu, Shuai,Liu, Jie,et al. Low Intraprostatic DHT Promotes the Infiltration of CD8+ T Cells in BPH Tissues via Modulation of CCL5 Secretion[J]. MEDIATORS OF INFLAMMATION,2014.
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