IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Analysis of Low-Frequency Mutations Associated with Drug Resistance to Raltegravir before Antiretroviral Treatment
Liu, Jia1,4; Miller, Michael D.3; Danovich, Robert M.3; Vandergrift, Nathan1; Cai, Fangping1; Hicks, Charles B.2; Hazuda, Daria J.3; Gao, Feng1
刊名ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2011-03-01
DOI10.1128/AAC.01492-10
55期:3页:1114-1119
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology ; Pharmacology & Pharmacy
资助者Merck ; National Institutes of Health ; Merck ; National Institutes of Health
研究领域[WOS]Microbiology ; Pharmacology & Pharmacy
关键词[WOS]VIRUS TYPE-1 INTEGRASE ; TREATMENT-NAIVE ; REVERSE-TRANSCRIPTASE ; HIV-1 INFECTION ; POPULATIONS ; THERAPY ; INHIBITORS ; VARIANTS ; FAILURE ; EVOLUTION
英文摘要

Raltegravir is highly efficacious in the treatment of HIV-1 infection. The prevalence and impact on virologic outcome of low-frequency resistant mutations among HIV-1-infected patients not previously treated with raltegravir have not been fully established. Samples from HIV treatment-experienced patients entering a clinical trial of raltegravir treatment were analyzed using a parallel allele-specific sequencing (PASS) assay that assessed six primary and six secondary integrase mutations. Patients who achieved and sustained virologic suppression (success patients, n = 36) and those who experienced virologic rebound (failure patients, n = 35) were compared. Patients who experienced treatment failure had twice as many raltegravir-associated resistance mutations prior to initiating treatment as those who achieved sustained virologic success, but the difference was not statistically significant. The frequency of nearly all detected resistance mutations was less than 1% of viral population, and the frequencies of mutations between the success and failure groups were similar. Expansion of pre-existing mutations (one primary and five secondary) was observed in 16 treatment failure patients in whom minority resistant mutations were detected at baseline, suggesting that they might play a role in the development of drug resistance. Two or more mutations were found in 13 patients (18.3%), but multiple mutations were not present in any single viral genome by linkage analysis. Our study demonstrates that low-frequency primary RAL-resistant mutations were uncommon, while minority secondary RAL-resistant mutations were more frequently detected in patients naive to raltegravir. Additional studies in larger populations are warranted to fully understand the clinical implications of these mutations.

语种英语
所属项目编号IISP 33026 ; GM065057 ; AI64518
资助者Merck ; National Institutes of Health ; Merck ; National Institutes of Health
WOS记录号WOS:000287687100022
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58251
Collection北京大学基础医学院_病原生物学系
作者单位1.Merck & Co Inc, West Point, PA USA
2.Duke Univ, Duke Human Vaccine Inst, Med Ctr, Durham, NC 27710 USA
3.Duke Univ, Dept Med, Med Ctr, Durham, NC 27710 USA
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jia,Miller, Michael D.,Danovich, Robert M.,et al. Analysis of Low-Frequency Mutations Associated with Drug Resistance to Raltegravir before Antiretroviral Treatment[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2011,55(3):1114-1119.
APA Liu, Jia.,Miller, Michael D..,Danovich, Robert M..,Vandergrift, Nathan.,Cai, Fangping.,...&Gao, Feng.(2011).Analysis of Low-Frequency Mutations Associated with Drug Resistance to Raltegravir before Antiretroviral Treatment.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,55(3),1114-1119.
MLA Liu, Jia,et al."Analysis of Low-Frequency Mutations Associated with Drug Resistance to Raltegravir before Antiretroviral Treatment".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 55.3(2011):1114-1119.
Files in This Item: Download All
File Name/Size DocType Version Access License
Analysis of Low-Freq(496KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Liu, Jia]'s Articles
[Miller, Michael D.]'s Articles
[Danovich, Robert M.]'s Articles
百度学术
百度学术Similar articles in
[Liu, Jia]'s Articles
[Miller, Michael D.]'s Articles
[Danovich, Robert M.]'s Articles
必应学术
必应学术Similar articles in
[Liu, Jia]'s Articles
[Miller, Michael D.]'s Articles
[Danovich, Robert M.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Analysis of Low-Frequency Mutations Associated with Drug Resistance to Raltegravir before Antiretroviral Treatment.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.