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学科主题: 临床医学
题名:
Gemcitabine based combination regimens for treatment of refractory advanced breast cancer
作者: Che Li; Di Li-jun; Song Guo-hong; Jia Jun; Yu Jing; Wang Xiao-li; Zhu Yu-lin; Jiang Han-fang; Liang Xu
关键词: advanced breast cancer ; gemcitabine ; salvage chemotherapy ; anthracycline ; taxane
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2008-09-01
DOI: 10.1007/s11670-008-0194-x
卷: 20, 期:3, 页:194-201
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PHASE-II TRIAL ; COLONY-STIMULATING FACTOR ; ADMINISTERED EVERY ; 2ND-LINE TREATMENT ; DOCETAXEL ; VINORELBINE ; CHEMOTHERAPY
英文摘要:

Objective: Anthracycline and taxane are the standard agents in combined chemotherapy of advanced breast cancer. However, when these agents based chemotherapy is failure, the selection of salvage regimen is still of problem. Gemcitabine, an active agent in both lung cancer and pancreas cancer, is demonstrated effective in breast caner. But there have been relatively less data of gemcitabine in anthracycline and/or taxane-resistant breast cancer. Therefore we employe this study to explore the efficacy and safety of gemcitabine based combination regimen in this population. Methods: From May 2002 to March 2006, 28 patients with measurable lesion of advanced metastatic breast cancer who were resistant to prior anthracycline and taxane based chemotherapy were enrolled. Patients were treated with gemcitabine based combination chemotherapy with a median cycles of 3 (range 2-6). Results: The overall response rate was 28.6% (8/28), with 1 CR (Complete response 3.5%) and 7 PRs (Partial response 25%). Stable disease was seen in 8 patients (28.6%) while disease progressed in 12 patiens (42.8%). The median time to progression was 4.5 m (range, 2-23 m). The main toxicity included bone marrow depression, alopecia, mucositis and peripheral neurotoxicity. The grade 3 to 4 clinical adverse effect was leukopenia in 5 cases (17.9%) and thrombocytopenia in 8 cases (30%). Conclusion: Gemcitabine based combination regimens is feasible in anthracycline and taxane-resistant advanced breast cancer. The clinical response and TTP is acceptable with limited toxicity pattern.

语种: 英语
WOS记录号: WOS:000259368400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58252
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Breast Canc Internal Oncol, Beijing 100142, Peoples R China

Recommended Citation:
Che Li,Di Li-jun,Song Guo-hong,et al. Gemcitabine based combination regimens for treatment of refractory advanced breast cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(3):194-201.
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