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Diurnal variation in cue-induced responses among protracted abstinent heroin users
Ren, Zhen-Yu1; Zhang, Xiao-Li1; Liu, Yu1; Zhao, Li-Yan1; Shi, Jie1; Bao, Yanping1; Zhang, Xiang Yang2; Kosten, Thomas R.2; Lu, Lin1
关键词Heroin Craving Cue reactivity Diurnal variation
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2009
DOI10.1016/j.pbb.2008.08.023
91期:3页:468-472
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]PATIENT-CONTROLLED ANALGESIA ; COCAINE-DEPENDENT PATIENTS ; DRUG-RELATED CUES ; OPIATE ADDICTS ; TRYPTOPHAN DEPLETION ; SMOKING CUES ; LONG-TERM ; REACTIVITY ; EXPOSURE ; STRESS
英文摘要

Objectives: The physiological and psychological responses to drug cue exposure have been assessed in substance abusers. However, there is no study to demonstrate whether the responses to drug cue exposure are diurnal dependence. The present study was to examine whether there was a variation in drug-related cue reactivity across the diurnal cycle among recently abstinent opiate addicts.

Methods: Four groups of 20 abstinent heroin dependent patients (n=80) were exposed to both neutral and drug-related videos at four separate times during the day: 8:00,12:00,16:00, and 20:00 h. Physiological and psychological responses, including heart rate, blood pressure, heroin craving, and subjective anxiety were assessed before and after each cue exposure.

Results: Drug cue significantly increased craving ratings compared to neutral cues across all the four separate times of day. Drug cue-induced craving was greater in the morning (8:00 am) than noon (12:00 pm), but was similar to evening assessments (8 pm). Drug cues also significantly increased anxiety, which positively correlated with cue-induced craving. Drug cues increased heart rate, systolic and diastolic blood pressures, which were not correlated with cue-induced craving or anxiety. However, no time effects were found on the three physiological measures.

Conclusions: Cue-induced craving could be profoundly affected by the time points of cue exposure, using cue-reactivity paradigm. The relative sensitivity of morning and evening assessments of drug craving suggests a need for replication and further research on mechanisms contributing to these diurnal variations. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000263014500031
项目编号2003CB515400 ; 2006AA02Z4D1 ; 30611120528 ; K05-DA0454
资助机构National Basic Research Program of China ; National High Technology Research and Development Program of China ; China-Canada Joint Health Research Program ; US National Institute oil Drug Abuse
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58253
专题北京大学第三临床医学院_药剂科
北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Ren, Zhen-Yu,Zhang, Xiao-Li,Liu, Yu,et al. Diurnal variation in cue-induced responses among protracted abstinent heroin users[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,91(3):468-472.
APA Ren, Zhen-Yu.,Zhang, Xiao-Li.,Liu, Yu.,Zhao, Li-Yan.,Shi, Jie.,...&Lu, Lin.(2009).Diurnal variation in cue-induced responses among protracted abstinent heroin users.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,91(3),468-472.
MLA Ren, Zhen-Yu,et al."Diurnal variation in cue-induced responses among protracted abstinent heroin users".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 91.3(2009):468-472.
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