北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
Expression of Delta DNMT3B variants and its association with estrogen/progestogen receptor status in breast cancer
作者: Liu, Ning-hong; Yang, Lu; Zhuo, Ming-lei; Wang, Jie; Wang, Shu-hang; Zhao, Jun; Bai, Hua
关键词: Delta DNMT3B variants ; RT-PCR ; Breast cancer ; Estrogen receptor ; Progestogen receptor
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2009-09-01
DOI: 10.1007/s11670-009-0229-y
卷: 21, 期:3, 页:229-234
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CELL LUNG-CANCER ; MESSENGER-RNA EXPRESSION ; DNA METHYLTRANSFERASES ; METHYLATION STATUS ; RASSF1A ; EPIGENETICS ; P16(INK4A) ; CARCINOMAS ; DNMT3B ; 3B
英文摘要:

Our previous study has showed that Delta DNMT3B is the predominant form of DNMT3B in non-small cell lung cancer (NSCLC). In this study, we aimed to explore the expression patterns of the Delta DNMT3B variants in breast cancer and to identify whether the pattern was similar to that in NSCLC or not and its clinical significance.

Expression of seven Delta DNMT3B variants in 59 breast cancer and the corresponding normal tissue was measured using RT-PCR. The correlations between the expressions of Delta DNMT3B variants and the clinical parameters including ER/PR status, clincopathologic feature and survivals were analyzed.

There were significant differences in the expression ratios of Delta DNMT3B1-7 variants between breast cancer tissues and normal tissues (P < 0.001). The positive ratio of Delta DNMT3B1-7 variants were 66%, 71%, 17%, 51%, 76.2%, 50% and 61% in tumor tissue, respectively; while 16%, 8.4%, 3.38%, 3.38%, 11.8%, 13.5% and 5.08% in the corresponding normal tissue, which was different from the pattern of Delta DNMT3B1-7 expression in NSCLC (62%, 76%, 2.5%, 46%, 18%, 27% and 16% in tumor tissue, respectively; while 18%, 11%, 0%, 3.3%, 0%, 0% and 0% in normal lung tissue, respectively; P < 0.0001). Expressions of Delta DNMT3B2, 3B4 and 3B7 were higher in the patients with negative estrogen receptor (ER) than those with positive estrogen receptor (P=0.035, P=0.0141 and P=0.0219, respectively). Delta DNMT3B7 expression was higher for the patients with negative progestogen receptor (PR) compared to those with positive progestogen receptor (P=0.0379). Expression ratio of Delta DNMT3B5 in stage III tumors is lower than that in stage I/II ones (P= 0.041). But we did not find any relation between the Delta DNMT3B variants and the patients′ survival.

The pattern of Delta DNMT3B variants in breast cancer is different from that in NSCLC. Expressions of Delta DNMT3B2, 3B4 and 3B7 are associated with estrogen receptors status. While Delta DNMT3B7 is associated with progestogen receptor. No relation between the Delta DNMT3B variants and the patients′ survival were found.

语种: 英语
所属项目编号: 30572104 ; 30772472
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000268869500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58258
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Thorac Med Oncol,Beijing Canc Ho, Beijing 100142, Peoples R China

Recommended Citation:
Liu, Ning-hong,Yang, Lu,Zhuo, Ming-lei,et al. Expression of Delta DNMT3B variants and its association with estrogen/progestogen receptor status in breast cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(3):229-234.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Ning-hong]'s Articles
[Yang, Lu]'s Articles
[Zhuo, Ming-lei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Ning-hong]‘s Articles
[Yang, Lu]‘s Articles
[Zhuo, Ming-lei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace