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学科主题: 临床医学
题名:
Identification and characterization of a novel p42.3 gene astumor-s pecific and mitosis phase-dependent expression in gastric cancer
作者: Xu, X.; Li, W.; Fan, X.; Liang, Y.; Zhao, M.; Zhang, J.; Liang, Y.; Tong, W.; Wang, J.; Yang, W.; Lu, Y.
关键词: gastric cancer ; p42.3 ; cell cycle ; RNAi
刊名: ONCOGENE
发表日期: 2007-11-15
DOI: 10.1038/sj.onc.1210538
卷: 26, 期:52, 页:7371-7379
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
关键词[WOS]: CELL-CYCLE ; MOLECULAR-CLONING ; PROLIFERATION ; CHECKPOINT ; PHENOTYPE ; PROTEINS
英文摘要:

Multiple genetic alterations are attributed to gastric cancer (GC); however, only a few critical genes have been identified so far. In this study, we isolated and characterized a novel gene p42.3, represented as tumor-specific and mitosis phase-dependent expression protein in GC cell line BGC823. Our data showed that the expression of p42.3 was cell cycle-dependent in GC cell lines. Moreover, p42.3 was specifically expressed in primary GC tissues but not in the matched normal mucosa of stomach, and this gene was expressed in diverse embryonic tissues. Furthermore, significant suppression of cell proliferation and tumorigenicity were detected and G(2)/M phase arrest was observed in cell line BGC823 depleted of p42.3 expression by RNAi technique, and we confirmed the expression changes of cyclin B1 and Chk2 following the silence of p42.3. Taken together, we cloned and characterized p42.3 gene that was specifically expressed in GC tumors but not in normal gastric mucosa, and the gene was associated with M-phase regulation. Moreover, p42.3 might be involved in cell proliferation and tumorigenesis; therefore, this gene might have potential applications in the diagnosis or treatment of GC.

语种: 英语
WOS记录号: WOS:000250955700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58263
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Genom Inst, Beijing, Peoples R China
2.Peking Univ, Sch Oncol, Inst Canc Res, Oncol Mol Lab, Beijing 100871, Peoples R China
3.Tsing Hua Univ, Natl Engn Res Ctr Biochip Technol, Sch Med, Beijing 100084, Peoples R China

Recommended Citation:
Xu, X.,Li, W.,Fan, X.,et al. Identification and characterization of a novel p42.3 gene astumor-s pecific and mitosis phase-dependent expression in gastric cancer[J]. ONCOGENE,2007,26(52):7371-7379.
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