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The S447X polymorphism of the lipoprotein lipase gene is associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension
Liu, AP; Lee, LM; Zhan, SY; Cao, WH; Lv, J; Guo, XX; Hu, YH
关键词lipoprotein lipase polymorphism dyslipidemia essential hypertension
刊名JOURNAL OF HYPERTENSION
2004-08-01
DOI10.1097/01.hjh.0000125456.28861.e4
22期:8页:1503-1509
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CORONARY-ARTERY-DISEASE ; LOW-DENSITY ; PLASMA TRIGLYCERIDES ; NONSENSE MUTATION ; HDL CHOLESTEROL ; HEART-DISEASE ; RISK ; ATHEROSCLEROSIS ; RECEPTOR ; STROKE
英文摘要

Objective To investigate the association between the S447X polymorphism of the lipoprotein lipase (LPL) gene and lipoprotein lipid and blood pressure (BP) levels in 904 Chinese subjects with essential hypertension.

Method Five hundred and sixty-three male and 341 female patients (aged 35-69 years) were randomly selected from hypertensive patients diagnosed in the Community-based Comprehensive Studies on Prevention and Control of Hypertension Project in China (CCPACH) and not treated with anti hypertensive medications for at least 2 weeks immediately before blood collection.

Results After multivariate adjustment for age, body mass index (BMI), smoking status, alcohol intake and serum glucose, the X447 allele was significantly associated with low triglyceride, log triglyceride: high-density lipoprotein (HDL)-cholesterol ratio and high HDL-cholesterol levels compared with the S447S genotype, but not with BP levels in the whole study population. However, upon stratification for dyslipidemic status, the X447 allele was associated with higher systolic blood pressure (SBP) (P<0.05) and pulse pressure (PP) (P<0.05) compared with the S447S genotype after multivariate adjustment in dyslipidemic subjects, but not in those without dyslipidemia. A statistically significant interaction between the LPL S447X polymorphism and dyslipidemic status was observed for SBP and PP levels, suggesting that dyslipidemic status might modify the effect of the LPL S447X polymorphism on BP levels.

Conclusions Our findings suggest that a high concentration of triglyceride and/or low concentration of HDL-cholesterol are associated with high SBP and PP in hypertensive patients with the X447 allele of the LPL gene.

语种英语
WOS记录号WOS:000222982600014
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58267
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China
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GB/T 7714
Liu, AP,Lee, LM,Zhan, SY,et al. The S447X polymorphism of the lipoprotein lipase gene is associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension[J]. JOURNAL OF HYPERTENSION,2004,22(8):1503-1509.
APA Liu, AP.,Lee, LM.,Zhan, SY.,Cao, WH.,Lv, J.,...&Hu, YH.(2004).The S447X polymorphism of the lipoprotein lipase gene is associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension.JOURNAL OF HYPERTENSION,22(8),1503-1509.
MLA Liu, AP,et al."The S447X polymorphism of the lipoprotein lipase gene is associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension".JOURNAL OF HYPERTENSION 22.8(2004):1503-1509.
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