IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科
学科主题临床医学
Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion
Liu, BL; Hao, JQ; Pan, YS; Luo, B; Westgard, B; Heremans, Y; Sutherland, DER; Hering, BJ; Guo, ZG
关键词islet transplantation tolerance type 1 diabetes autoimmunity chimerism bone marrow transplantation
刊名AMERICAN JOURNAL OF TRANSPLANTATION
2006-05-01
DOI10.1111/j.1600-6143.2006.01283.x
6期:5页:933-946
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]REGULATORY T-CELLS ; NONOBESE DIABETIC MICE ; BONE-MARROW-TRANSPLANTATION ; IMMUNOLOGICAL SELF-TOLERANCE ; VERSUS-HOST-DISEASE ; NOD MICE ; HEMATOPOIETIC CHIMERISM ; ADOPTIVE IMMUNOTHERAPY ; CONDITIONING THERAPY ; ALLOGENEIC CHIMERAS
英文摘要

Inducing donor chimerism is the most consistently successful approach to achieve transplant tolerance. We found that a low level of donor chimerism, which was induced by a relatively non-toxic approach, induced donor-specific tolerance to islet allografts in chemically induced diabetic mice. However, a similar level of donor chimerism could not protect donor islet allografts in non-obese diabetic (NOD) mice that spontaneously developed autoimmune diabetes. Rejection of donor islet allografts in diabetic NOD mice with a low level of donor chimerism was mediated by recurrent autoimmunity. We used post-transplant donor lymphocyte infusion (DLI) to increase donor chimerism and to induce tolerance to islet allografts. DLI significantly increased donor chimerism and promoted donor-specific tolerance to islet allografts in diabetic NOD mice. Self-tolerance to islet autoantigens was restored and restoring self-tolerance is mediated by immunoregulation. Thus, our data showed that adoptive immunotherapy with post-transplant DLI after establishing a low level of donor chimerism as a platform enhances donor chimerism, induces donor-specific tolerance to islet allografts and restores self-tolerance in the setting of autoimmune diabetes. Our data also showed that central tolerance is not sufficient to induce tolerance and peripheral tolerance through immunoregulation for restoring self-tolerance is required in the setting of autoimmune diabetes.

语种英语
WOS记录号WOS:000236860700010
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58270
专题北京大学第一临床医学院_普通外科
作者单位1.Beijing Univ, Dept Surg, Hosp 1, Beijing 100871, Peoples R China
2.Univ Alberta, Dept Surg, Edmonton, AB, Canada
3.Univ Minnesota, Inst Immunol & Transplantat, Dept Surg & Diabet, Minneapolis, MN 55455 USA
4.China Med Univ, Second Affiliated Hosp, Dept Surg, Shenyang, Liaoning, Peoples R China
5.Univ Minnesota, Stem Cell Inst, Minneapolis, MN 55455 USA
推荐引用方式
GB/T 7714
Liu, BL,Hao, JQ,Pan, YS,et al. Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion[J]. AMERICAN JOURNAL OF TRANSPLANTATION,2006,6(5):933-946.
APA Liu, BL.,Hao, JQ.,Pan, YS.,Luo, B.,Westgard, B.,...&Guo, ZG.(2006).Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion.AMERICAN JOURNAL OF TRANSPLANTATION,6(5),933-946.
MLA Liu, BL,et al."Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion".AMERICAN JOURNAL OF TRANSPLANTATION 6.5(2006):933-946.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, BL]的文章
[Hao, JQ]的文章
[Pan, YS]的文章
百度学术
百度学术中相似的文章
[Liu, BL]的文章
[Hao, JQ]的文章
[Pan, YS]的文章
必应学术
必应学术中相似的文章
[Liu, BL]的文章
[Hao, JQ]的文章
[Pan, YS]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。