IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科
学科主题临床医学
Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion
Liu, BL; Hao, JQ; Pan, YS; Luo, B; Westgard, B; Heremans, Y; Sutherland, DER; Hering, BJ; Guo, ZG
关键词islet transplantation tolerance type 1 diabetes autoimmunity chimerism bone marrow transplantation
刊名AMERICAN JOURNAL OF TRANSPLANTATION
2006-05-01
DOI10.1111/j.1600-6143.2006.01283.x
6期:5页:933-946
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]REGULATORY T-CELLS ; NONOBESE DIABETIC MICE ; BONE-MARROW-TRANSPLANTATION ; IMMUNOLOGICAL SELF-TOLERANCE ; VERSUS-HOST-DISEASE ; NOD MICE ; HEMATOPOIETIC CHIMERISM ; ADOPTIVE IMMUNOTHERAPY ; CONDITIONING THERAPY ; ALLOGENEIC CHIMERAS
英文摘要

Inducing donor chimerism is the most consistently successful approach to achieve transplant tolerance. We found that a low level of donor chimerism, which was induced by a relatively non-toxic approach, induced donor-specific tolerance to islet allografts in chemically induced diabetic mice. However, a similar level of donor chimerism could not protect donor islet allografts in non-obese diabetic (NOD) mice that spontaneously developed autoimmune diabetes. Rejection of donor islet allografts in diabetic NOD mice with a low level of donor chimerism was mediated by recurrent autoimmunity. We used post-transplant donor lymphocyte infusion (DLI) to increase donor chimerism and to induce tolerance to islet allografts. DLI significantly increased donor chimerism and promoted donor-specific tolerance to islet allografts in diabetic NOD mice. Self-tolerance to islet autoantigens was restored and restoring self-tolerance is mediated by immunoregulation. Thus, our data showed that adoptive immunotherapy with post-transplant DLI after establishing a low level of donor chimerism as a platform enhances donor chimerism, induces donor-specific tolerance to islet allografts and restores self-tolerance in the setting of autoimmune diabetes. Our data also showed that central tolerance is not sufficient to induce tolerance and peripheral tolerance through immunoregulation for restoring self-tolerance is required in the setting of autoimmune diabetes.

语种英语
WOS记录号WOS:000236860700010
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58270
Collection北京大学第一临床医学院_普通外科
作者单位1.Beijing Univ, Dept Surg, Hosp 1, Beijing 100871, Peoples R China
2.Univ Alberta, Dept Surg, Edmonton, AB, Canada
3.Univ Minnesota, Inst Immunol & Transplantat, Dept Surg & Diabet, Minneapolis, MN 55455 USA
4.China Med Univ, Second Affiliated Hosp, Dept Surg, Shenyang, Liaoning, Peoples R China
5.Univ Minnesota, Stem Cell Inst, Minneapolis, MN 55455 USA
Recommended Citation
GB/T 7714
Liu, BL,Hao, JQ,Pan, YS,et al. Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion[J]. AMERICAN JOURNAL OF TRANSPLANTATION,2006,6(5):933-946.
APA Liu, BL.,Hao, JQ.,Pan, YS.,Luo, B.,Westgard, B.,...&Guo, ZG.(2006).Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion.AMERICAN JOURNAL OF TRANSPLANTATION,6(5),933-946.
MLA Liu, BL,et al."Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion".AMERICAN JOURNAL OF TRANSPLANTATION 6.5(2006):933-946.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Liu, BL]'s Articles
[Hao, JQ]'s Articles
[Pan, YS]'s Articles
百度学术
百度学术Similar articles in
[Liu, BL]'s Articles
[Hao, JQ]'s Articles
[Pan, YS]'s Articles
必应学术
必应学术Similar articles in
[Liu, BL]'s Articles
[Hao, JQ]'s Articles
[Pan, YS]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.