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学科主题: 公共卫生
题名:
LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING A beta(1-42) OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS
作者: Li, Q.; Zhao, H. F.; Zhang, Z. F.; Liu, Z. G.; Pei, X. R.; Wang, J. B.; Li, Y.
关键词: green tea catechins ; learning and memory ; Morris water maze ; A beta(1-42) oligomers
刊名: NEUROSCIENCE
发表日期: 2009-10-20
DOI: 10.1016/j.neuroscience.2009.07.014
卷: 163, 期:3, 页:741-749
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: AMYLOID PRECURSOR PROTEIN ; ELEMENT-BINDING PROTEIN ; A-BETA OLIGOMERIZATION ; ALZHEIMERS-DISEASE ; POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE ; NEURODEGENERATIVE DISEASES ; THERAPEUTIC AGENTS ; SOLUBLE OLIGOMERS ; GENE-EXPRESSION ; TRANSGENIC MICE
英文摘要:

The senescence-accelerated mouse prone-8 (SAMP8) is characterized by early onset of learning and memory deficits along with spontaneous overproduction of soluble beta-amyloid peptide (A beta) in the brain. In our study, 4 month old male SAMP8 mice were orally administered 0.05% and 0.1% green tea catechins (GTC, w/v) in drinking water for 6 months. We found that a supplementation with 0.05% or 0.1% GTC prevented spatial learning and memory impairments of mice in the Morris water maze. Better performance of GTC-treated mice was associated with decreased levels of A beta(1-42) oligomers in the hippocampus. The activity of the protein kinase A/cAMP-response element binding protein (PKA/CREB) pathway, one of the molecular targets of A beta oligomers which is crucial for late long-term potentiation and long-term memory formation, was significantly increased after GTC administration. We also found that chronic 0.05% or 0.1% GTC consumption prevented the reductions of three representative proteins of synaptic function and synaptic structure, including brain-derived neurotrophic factor(BDNF), post-synaptic density protein-95 (PSD95) and Ca2+/calmodulin-dependent protein kinase 11 (CaMKII). These results demonstrated that long-term 0.05% or 0.1% green tea catechin administration may prevent spatial learning and memory decline of SAMP8 mice by decreasing A beta(1-42) oligomers and upregulating synaptic plasticity-related proteins in the hippocampus. (c) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000270284900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58271
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Q.,Zhao, H. F.,Zhang, Z. F.,et al. LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING A beta(1-42) OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS[J]. NEUROSCIENCE,2009,163(3):741-749.
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