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LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING A beta(1-42) OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS
Li, Q.; Zhao, H. F.; Zhang, Z. F.; Liu, Z. G.; Pei, X. R.; Wang, J. B.; Li, Y.
关键词green tea catechins learning and memory Morris water maze A beta(1-42) oligomers
刊名NEUROSCIENCE
2009-10-20
DOI10.1016/j.neuroscience.2009.07.014
163期:3页:741-749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]AMYLOID PRECURSOR PROTEIN ; ELEMENT-BINDING PROTEIN ; A-BETA OLIGOMERIZATION ; ALZHEIMERS-DISEASE ; POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE ; NEURODEGENERATIVE DISEASES ; THERAPEUTIC AGENTS ; SOLUBLE OLIGOMERS ; GENE-EXPRESSION ; TRANSGENIC MICE
英文摘要

The senescence-accelerated mouse prone-8 (SAMP8) is characterized by early onset of learning and memory deficits along with spontaneous overproduction of soluble beta-amyloid peptide (A beta) in the brain. In our study, 4 month old male SAMP8 mice were orally administered 0.05% and 0.1% green tea catechins (GTC, w/v) in drinking water for 6 months. We found that a supplementation with 0.05% or 0.1% GTC prevented spatial learning and memory impairments of mice in the Morris water maze. Better performance of GTC-treated mice was associated with decreased levels of A beta(1-42) oligomers in the hippocampus. The activity of the protein kinase A/cAMP-response element binding protein (PKA/CREB) pathway, one of the molecular targets of A beta oligomers which is crucial for late long-term potentiation and long-term memory formation, was significantly increased after GTC administration. We also found that chronic 0.05% or 0.1% GTC consumption prevented the reductions of three representative proteins of synaptic function and synaptic structure, including brain-derived neurotrophic factor(BDNF), post-synaptic density protein-95 (PSD95) and Ca2+/calmodulin-dependent protein kinase 11 (CaMKII). These results demonstrated that long-term 0.05% or 0.1% green tea catechin administration may prevent spatial learning and memory decline of SAMP8 mice by decreasing A beta(1-42) oligomers and upregulating synaptic plasticity-related proteins in the hippocampus. (c) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000270284900003
项目编号2006BAD27B08
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:85[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58271
专题北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Q.,Zhao, H. F.,Zhang, Z. F.,et al. LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING A beta(1-42) OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS[J]. NEUROSCIENCE,2009,163(3):741-749.
APA Li, Q..,Zhao, H. F..,Zhang, Z. F..,Liu, Z. G..,Pei, X. R..,...&Li, Y..(2009).LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING A beta(1-42) OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS.NEUROSCIENCE,163(3),741-749.
MLA Li, Q.,et al."LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING A beta(1-42) OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS".NEUROSCIENCE 163.3(2009):741-749.
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