北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP(3+) Treg cells in chronic HCV infected-patients
作者: Shen, Tao2; Zheng, Jiajia2; Liang, Hua1; Xu, Chunhui2; Chen, Xiangmei2; Zhang, Ting2; Xu, Qiang2; Lu, Fengmin2
刊名: VIROLOGY JOURNAL
发表日期: 2011-06-07
DOI: 10.1186/1743-422X-8-279
卷: 8, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HEPATITIS-C-VIRUS ; REGULATORY T-CELLS ; IMMUNE-RESPONSES ; MEMORY ; LYMPHOCYTES ; DYSFUNCTION ; SUBSETS ; EXHAUSTION ; PHENOTYPE ; RECEPTOR
英文摘要:

Background: Both regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and development of HCV long-term persistence.

Methods: CD45RA and CD27 were employed to separate peripheral Tregs as naive/central memory/effector memory/effector subsets. The phenotypic characteristics and PD-1 expression of Tregs were studied by flow cytometry.

Results: In the present study, the majority of Tregs was identified as central memory phenotype in chronic hepatitis C patients compared with nearly equal contribution of naive and central memory subsets in healthy individuals. PD-1 expression was elevated in all CD4+ T cell subset in chronic HCV infected patients, including Tregs. Of note, higher level of PD-1 expression was found on TEM- and effector-Treg than naive- and TCM-Tregs subsets. The ratio of TEM-Tregs/naive-Tregs and TEM-Tregs/TCM-Tregs regarding to PD-1 MFI were significantly lower in CHC patients compared to controls.

Conclusions: Our study indicated that distinctive characteristics of PD-1 expression on Tregs in HCV infection suggests associated with impaired adaptive immunity as well as viral long-term persistence. The cross talk between Treg cells and PD-1 induced inhibition in chronic HCV infection deserved further exploration for HCV infection associated immune pathogenesis.

语种: 英语
所属项目编号: 2008ZX10002-012 ; 2008ZX10002-013 ; 2009ZX10004-903
项目资助者: National S& ; T Major Project for Infectious Diseases
WOS记录号: WOS:000292330200001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58272
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP(3+) Treg cells in chronic HCV infected-patients.pdf(2147KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China

Recommended Citation:
Shen, Tao,Zheng, Jiajia,Liang, Hua,et al. Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP(3+) Treg cells in chronic HCV infected-patients[J]. VIROLOGY JOURNAL,2011,8(1).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shen, Tao]'s Articles
[Zheng, Jiajia]'s Articles
[Liang, Hua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shen, Tao]‘s Articles
[Zheng, Jiajia]‘s Articles
[Liang, Hua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace