IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP(3+) Treg cells in chronic HCV infected-patients
Shen, Tao2; Zheng, Jiajia2; Liang, Hua1; Xu, Chunhui2; Chen, Xiangmei2; Zhang, Ting2; Xu, Qiang2; Lu, Fengmin2
刊名VIROLOGY JOURNAL
2011-06-07
DOI10.1186/1743-422X-8-279
8期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
资助者National S& ; T Major Project for Infectious Diseases ; National S& ; T Major Project for Infectious Diseases
研究领域[WOS]Virology
关键词[WOS]HEPATITIS-C-VIRUS ; REGULATORY T-CELLS ; IMMUNE-RESPONSES ; MEMORY ; LYMPHOCYTES ; DYSFUNCTION ; SUBSETS ; EXHAUSTION ; PHENOTYPE ; RECEPTOR
英文摘要

Background: Both regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and development of HCV long-term persistence.

Methods: CD45RA and CD27 were employed to separate peripheral Tregs as naive/central memory/effector memory/effector subsets. The phenotypic characteristics and PD-1 expression of Tregs were studied by flow cytometry.

Results: In the present study, the majority of Tregs was identified as central memory phenotype in chronic hepatitis C patients compared with nearly equal contribution of naive and central memory subsets in healthy individuals. PD-1 expression was elevated in all CD4+ T cell subset in chronic HCV infected patients, including Tregs. Of note, higher level of PD-1 expression was found on TEM- and effector-Treg than naive- and TCM-Tregs subsets. The ratio of TEM-Tregs/naive-Tregs and TEM-Tregs/TCM-Tregs regarding to PD-1 MFI were significantly lower in CHC patients compared to controls.

Conclusions: Our study indicated that distinctive characteristics of PD-1 expression on Tregs in HCV infection suggests associated with impaired adaptive immunity as well as viral long-term persistence. The cross talk between Treg cells and PD-1 induced inhibition in chronic HCV infection deserved further exploration for HCV infection associated immune pathogenesis.

语种英语
所属项目编号2008ZX10002-012 ; 2008ZX10002-013 ; 2009ZX10004-903
资助者National S& ; T Major Project for Infectious Diseases ; National S& ; T Major Project for Infectious Diseases
WOS记录号WOS:000292330200001
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58272
Collection北京大学基础医学院_病原生物学系
作者单位1.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Shen, Tao,Zheng, Jiajia,Liang, Hua,et al. Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP(3+) Treg cells in chronic HCV infected-patients[J]. VIROLOGY JOURNAL,2011,8(1).
APA Shen, Tao.,Zheng, Jiajia.,Liang, Hua.,Xu, Chunhui.,Chen, Xiangmei.,...&Lu, Fengmin.(2011).Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP(3+) Treg cells in chronic HCV infected-patients.VIROLOGY JOURNAL,8(1).
MLA Shen, Tao,et al."Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP(3+) Treg cells in chronic HCV infected-patients".VIROLOGY JOURNAL 8.1(2011).
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