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学科主题基础医学
DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth
Ma, Teng1,2; Shi, Taiping1,2,3; Huang, Jing1,2; Wu, Lina1,2; Hu, Fanlei1,2; He, PengFei3; Deng, WeiWei3; Gao, Peng3; Zhang, Yingmei1,2; Song, Quansheng1,2; Ma, Dalong1,2,3; Qiu, Xiaoyan1,2
刊名CANCER SCIENCE
2008-11-01
DOI10.1111/j.1349-7006.2008.00929.x
99期:11页:2128-2135
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DNA-DAMAGE ; P53 ; LOCALIZATION ; BINDING ; PROTEIN ; CANCER ; ARREST ; SMART
英文摘要

DCUN1D3 (DCN1, defective in cullin neddylation 1, domain containing 3) was found during the process of high throughput screening of novel human genes associated with serum response element (SRE) pathway activation. The DCUN1D3 gene is highly conserved among vertebrates. Human DCUN1D3 complementary DNA (cDNA) encodes 304 amino acids with an apparent molecular mass of 34 kDa. However, there has been no report about the function of DCUN1D3. This study detected that DCUN1D3 was broadly expressed in several tumor tissues and cultured cell lines; however, UVC irradiation of different doses significantly increased DCUN1D3 expression level in these cancer cell lines. Over-expression of the DCUN1D3 inhibits cell growth in HeLa. When the DCUN1D3 gene was silenced by siRNA in UVC-treated HeLa, the cell cycle in S phase was remarkably blocked; furthermore, the UVC-induced cell death was inhibited. In addition, DCUN1D3 localized mainly in the cytoplasm and perinuclear, but after UVC treatment, the DCUN1D3 gradually entered the nucleus. All the results above indicate that DCUN1D3 is a novel UVC-response gene involved in cell cycle regulation and cell survival. (Cancer Sci 2008; 99: 2128-2135).

语种英语
WOS记录号WOS:000260730700004
项目编号2006AA02A305 ; 30371609
资助机构China High Tech 863 Program ; National Natural Science Foundation, China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58276
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学临床肿瘤学院_中心实验室
北京大学临床肿瘤学院_后勤处
作者单位1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
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GB/T 7714
Ma, Teng,Shi, Taiping,Huang, Jing,et al. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth[J]. CANCER SCIENCE,2008,99(11):2128-2135.
APA Ma, Teng.,Shi, Taiping.,Huang, Jing.,Wu, Lina.,Hu, Fanlei.,...&Qiu, Xiaoyan.(2008).DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth.CANCER SCIENCE,99(11),2128-2135.
MLA Ma, Teng,et al."DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth".CANCER SCIENCE 99.11(2008):2128-2135.
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