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学科主题: 基础医学
题名:
DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth
作者: Ma, Teng1,2; Shi, Taiping1,2,3; Huang, Jing1,2; Wu, Lina1,2; Hu, Fanlei1,2; He, PengFei3; Deng, WeiWei3; Gao, Peng3; Zhang, Yingmei1,2; Song, Quansheng1,2; Ma, Dalong1,2,3; Qiu, Xiaoyan1,2
刊名: CANCER SCIENCE
发表日期: 2008-11-01
DOI: 10.1111/j.1349-7006.2008.00929.x
卷: 99, 期:11, 页:2128-2135
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: DNA-DAMAGE ; P53 ; LOCALIZATION ; BINDING ; PROTEIN ; CANCER ; ARREST ; SMART
英文摘要:

DCUN1D3 (DCN1, defective in cullin neddylation 1, domain containing 3) was found during the process of high throughput screening of novel human genes associated with serum response element (SRE) pathway activation. The DCUN1D3 gene is highly conserved among vertebrates. Human DCUN1D3 complementary DNA (cDNA) encodes 304 amino acids with an apparent molecular mass of 34 kDa. However, there has been no report about the function of DCUN1D3. This study detected that DCUN1D3 was broadly expressed in several tumor tissues and cultured cell lines; however, UVC irradiation of different doses significantly increased DCUN1D3 expression level in these cancer cell lines. Over-expression of the DCUN1D3 inhibits cell growth in HeLa. When the DCUN1D3 gene was silenced by siRNA in UVC-treated HeLa, the cell cycle in S phase was remarkably blocked; furthermore, the UVC-induced cell death was inhibited. In addition, DCUN1D3 localized mainly in the cytoplasm and perinuclear, but after UVC treatment, the DCUN1D3 gradually entered the nucleus. All the results above indicate that DCUN1D3 is a novel UVC-response gene involved in cell cycle regulation and cell survival. (Cancer Sci 2008; 99: 2128-2135).

语种: 英语
所属项目编号: 2006AA02A305 ; 30371609
项目资助者: China High Tech 863 Program ; National Natural Science Foundation, China
WOS记录号: WOS:000260730700004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58276
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China

Recommended Citation:
Ma, Teng,Shi, Taiping,Huang, Jing,et al. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth[J]. CANCER SCIENCE,2008,99(11):2128-2135.
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