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学科主题: 公共卫生
题名:
Gastrointestinal Adverse Events of Glucagon-Like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis
作者: Sun, Feng1,2,3; Chai, Sanbao4; Yu, Kai5; Quan, Xiaochi1; Yang, Zhirong1; Wu, Shanshan1; Zhang, Yuan1; Ji, Linong6; Wang, Jun4; Shi, Luwen3
刊名: DIABETES TECHNOLOGY & THERAPEUTICS
发表日期: 2015
DOI: 10.1089/dia.2014.0188
卷: 17, 期:1, 页:35-42
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: RANDOMIZED CLINICAL-TRIALS ; IMPROVES GLYCEMIC CONTROL ; DOUBLE-BLIND ; PARALLEL-GROUP ; OPEN-LABEL ; EXENATIDE ; EFFICACY ; MELLITUS ; SAFETY ; LIRAGLUTIDE
英文摘要:

Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a new class of drugs used in the treatment of type 2 diabetes mellitus (T2DM). Gastrointestinal (GI) adverse events (AEs) are the most frequently reported treatment-related AEs for GLP-1 RAs. We aim to evaluate the effect of GLP-1 RAs on the incidence of GI AEs of T2DM.

Materials and Methods: The overview of the GI events of GLP-1 RAs has been performed on relevant publications through the literature search, such as MEDLINE, EMBASE, Cochrane Library, and ClinicalTrials.gov The manufacturer was contacted regarding unpublished data. We analyzed direct and indirect comparisons of different treatments using Bayesian network meta-analysis.

Results: Taspoglutide 30 mg once weekly (TAS30QW) and lixisenatide 30 mu g twice daily (LIX30BID) were ranked the top two drugs in terms of GI AEs versus placebo. The odds ratios of nausea and vomiting for TAS30QW were 11.8 (95% confidence interval [CI], 2.89, 46.9) and 51.7 (95% CI, 7.07, 415), respectively, and that of diarrhea was 4.93 (95% CI, 1.75, 14.7) for LIX30BID.

Conclusions: Our study found all GLP-1 RA dose regimens significantly increased the incidence of GI AEs, compared with placebo or conventional treatment. The occurrence of GI AEs was different with diverse dose regimens of GLP-1 RAs. TAS30QW had the maximum probability to occur nausea and vomiting, whereas LIX30BID had the maximum probability to cause development of diarrhea versus other treatments.

语种: 英语
所属项目编号: 81302508 ; 81370152 ; 81228001 ; 7142027 ; 20120001110015 ; 2010JC15
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Research Fund for the Doctoral Program of Higher Education ; Doctoral Fund of Corps
WOS记录号: WOS:000347538900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58278
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Tianjin Fifth Cent Hosp, Dept Orthoped, Tianjin, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
3.Shihezi Univ, Coll Med, Dept Prevent Med, Shihezi, Peoples R China
4.Peking Univ, Int Res Ctr Med Adm, Beijing 100871, Peoples R China
5.Capital Med Univ, Dept Physiol, Beijing 100069, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Feng,Chai, Sanbao,Yu, Kai,et al. Gastrointestinal Adverse Events of Glucagon-Like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis[J]. DIABETES TECHNOLOGY & THERAPEUTICS,2015,17(1):35-42.
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