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学科主题: 临床医学
题名:
Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer
作者: Cao, Bangwei2; Zhu, Linzhong3; Zhu, Shengtao1; Li, Danping4; Zhang, Chuanzhen4; Xu, Changqing4; Zhang, Shutian1
关键词: TIM-3 gene ; Susceptibility ; Gastric cancer
刊名: CANCER IMMUNOLOGY IMMUNOTHERAPY
发表日期: 2010-12-01
DOI: 10.1007/s00262-010-0910-5
卷: 59, 期:12, 页:1851-1857
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology
研究领域[WOS]: Oncology ; Immunology
关键词[WOS]: T-CELL IMMUNOGLOBULIN ; POLYMORPHISMS ; ASSOCIATION ; AUTOIMMUNE ; TOLERANCE ; RESPONSES ; IMMUNITY ; DISEASE
英文摘要:

T cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) could weaken the Th1-mediated anti-tumor responses and accelerate the tumor cell proliferation by inhabiting the production of IL-2 or IFN-gamma. This study was to assess the association between TIM-3 genetic variations and the development of gastric cancer.

Five polymorphisms located in the promoter or encoding region of TIM-3 gene were genotyped in 212 gastric cancer patients and 252 controls who matched with the patients on the frequency of age, gender, smoking, and drinking. Logistic regression was used to determine whether the inherited variations within TIM-3 gene were associated with gastric cancer risk. Linkage disequilibrium and Haplotype analyses were performed by using SHEsis program.

By the individual genotype analysis, three polymorphisms (-574G/T, -882C/T, and -1516G/T) within TIM-3 gene were significantly associated with gastric cancer in the study population [ORs (95% CIs): 2.74 (1.21-6.20), 3.19 (1.29-7.91), and 2.03 (1.15-3.59); respectively]. Among the gastric cancer patients, the relationship between the -1516 polymorphic genotype and the distant metastasis of tumor was found (OR = 2.21, 95% CI = 1.05-4.63). Under the analysis of haplotypes, an even stronger association with haplotype TTGCT was observed in gastric cancer risk (OR = 5.57, 95% CI: 1.04-29.80, P = 0.024).

These results indicated that the three genetic variations within the TIM-3 gene promoter may be associated with the increased susceptibility to gastric cancer, especially among the haplotypes with the risk.

语种: 英语
所属项目编号: 2007AA02Z4Z4 ; 7092103
项目资助者: National High Technology Research and Development Program of China ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000282184700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58281
Appears in Collections:北京大学临床肿瘤学院_介入治疗科_期刊论文

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作者单位: 1.Capital Med Univ, Dept Gastroenterol, Beijing Friendship Hosp, Beijing Digest Dis Ctr, Beijing 100050, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Oncol, Beijing 100050, Peoples R China
3.Peking Univ, Sch Oncol, Dept Intervent Therapy, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Qianfoshan Hosp, Dept Gastroenterol, Jinan 250014, Shandong, Peoples R China

Recommended Citation:
Cao, Bangwei,Zhu, Linzhong,Zhu, Shengtao,et al. Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2010,59(12):1851-1857.
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