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学科主题: 临床医学
题名:
Radio-labelling and Micro-PET Study of Cu-64 Labelled PnAO-1-(2-nitroimidazole) for Hypoxia Imaging
作者: Luo Zheng1; Zhu Hua1; Lin Xinfeng1; Hong Ye1; Xiao Shaowen2; Zhang Qiang3; Chu Taiwei3; Yang Zhi1
关键词: Nitroimidazole ; Cu-64 ; Positron emission tomography ; Hypoxia imaging
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2015-01-10
DOI: 10.7503/cjcu20140438
卷: 36, 期:1, 页:87-92
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: AMINE OXIME COMPLEXES ; BIOLOGICAL EVALUATION ; TUMOR HYPOXIA ; IN-VITRO ; CANCER ; BISNITROIMIDAZOLE ; MARKERS
英文摘要:

Monitoring hypoxia is very important for tumor treatment, the ideal hypoxia imaging agents should have a relatively long half-life and specific to hypoxic cells. However, such an ideal imaging agent has not been developed until now. In order to develop an ideal imaging agent for monitoring hypoxia, nitroimidazole imaging agent PnAO-1-(2-nitroimidazole) [BMS181321] was synthesized and radiolabeled with Cu-64 for Cu-64-BMS181321. The basic experimental process is as follows; the BMS181321 dissolved in sodium acetate buffer (pH =5. 5) was added to the eluent of (CuCl2)-Cu-64, and the solution was stirred and placed at room temperature for 10 min. The labelling efficiency and radiochemical purity of Cu-64-BMS181321 were all over 99%, determined by radio-HPLC. The Cu-64-BMS181321 was stable in physiological saline for more than 15 h, which was a meaningful characteristic for clinical application. After quality control, 21. 8 MBq of Cu-64-BMS181321 was injected into human pancreatic cancer xenograft mouse models via tale vein. Positron emission tomography (PET) images were taken at 4 and 8 h after the injection. PET imaging in human tumor models was excellent compared with other PET hypoxia imaging agents. In brief, the research results suggest that Cu-64-BMS181321 is potential for PET hypoxia imaging in clinical and should be further evaluated in clinic trial.

语种: 中文
所属项目编号: 81071198 ; 81172083 ; 81371592 ; 7132040
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation, China
WOS记录号: WOS:000348750100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58285
Appears in Collections:北京大学临床肿瘤学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Nucl Med,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Radiat Oncol, Beijing 100142, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Luo Zheng,Zhu Hua,Lin Xinfeng,et al. Radio-labelling and Micro-PET Study of Cu-64 Labelled PnAO-1-(2-nitroimidazole) for Hypoxia Imaging[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2015,36(1):87-92.
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