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Clonidine Improved Laboratory-Measured Decision-Making Performance in Abstinent Heroin Addicts
Zhang, Xiao-Li; Wang, Gui-Bin; Zhao, Li-Yan; Sun, Li-Li; Wang, Jun; Wu, Ping; Lu, Lin; Shi, Jie
刊名PLOS ONE
2012-01-23
DOI10.1371/journal.pone.0029084
7期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; Natural Science Foundation of China ; National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; Natural Science Foundation of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SPATIAL WORKING-MEMORY ; METHAMPHETAMINE-DEPENDENT SUBJECTS ; VENTROMEDIAL PREFRONTAL CORTEX ; CORTICAL COGNITIVE FUNCTION ; EXECUTIVE FUNCTIONS ; ORBITOFRONTAL CORTEX ; PARKINSONS-DISEASE ; AGONIST CLONIDINE ; IMPULSIVITY ; USERS
英文摘要

Background: Impulsivity refers to a wide spectrum of actions characterized by quick and nonplanned reactions to external and internal stimuli, without taking into account the possible negative consequences for the individual or others, and decision-making is one of the biologically dissociated impulsive behaviors. Changes in impulsivity may be associated with norepinephrine. Various populations of drug addicts all performed impulsive decision making, which is a key risk factor in drug dependence and relapse. The present study investigated the effects of clonidine, which decreased norepinephrine release through presynaptic alpha-2 receptor activation, on the impaired decision-making performance in abstinent heroin addicts.

Methodology/Principal Findings: Decision-making performance was assessed using the original version of Iowa Gambling Task (IGT). Both heroin addicts and normal controls were randomly assigned to three groups receiving clonidine, 0, 75 mu g or 150 mu g orally under double blind conditions. Psychiatric symptoms, including anxiety, depression and impulsivity, were rated on standardized scales. Heroin addicts reported higher scores on the Barratt Impulsiveness Scale and exhibited impaired decision-making on the IGT. A single high-dose of clonidine improved the decision-making performance in heroin addicts.

Conclusions/Significance: Our results suggest clonidine may have a potential therapeutic role in heroin addicts by improving the impaired impulsive decision-making. The current findings have important implications for behavioral and pharmacological interventions targeting decision-making in heroin addiction.

语种英语
所属项目编号2009CB522000 ; 7092058 ; 81000571 ; 91132719
资助者National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; Natural Science Foundation of China ; National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; Natural Science Foundation of China
WOS记录号WOS:000301570600002
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58287
专题中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiao-Li,Wang, Gui-Bin,Zhao, Li-Yan,et al. Clonidine Improved Laboratory-Measured Decision-Making Performance in Abstinent Heroin Addicts[J]. PLOS ONE,2012,7(1).
APA Zhang, Xiao-Li.,Wang, Gui-Bin.,Zhao, Li-Yan.,Sun, Li-Li.,Wang, Jun.,...&Shi, Jie.(2012).Clonidine Improved Laboratory-Measured Decision-Making Performance in Abstinent Heroin Addicts.PLOS ONE,7(1).
MLA Zhang, Xiao-Li,et al."Clonidine Improved Laboratory-Measured Decision-Making Performance in Abstinent Heroin Addicts".PLOS ONE 7.1(2012).
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