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学科主题临床医学
Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China
Liu, Fangfang1; Hang, Dong2; Deng, Qiuju1; Liu, Mengfei1; Xi, Longfu3,4; He, Zhonghu1; Zhang, Chaoting1; Sun, Min1; Liu, Ying1; Li, Jingjing1; Pan, Yaqi1; Ning, Tao1; Guo, Chuanhai1; Liang, Yongmei1; Xu, Ruiping5; Zhang, Lixin5; Cai, Hong1; Ke, Yang1
刊名SCIENTIFIC REPORTS
2015-10-27
DOI10.1038/srep15637
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HIV-POSITIVE MEN ; HPV INFECTION ; RISK-FACTORS ; PREVALENCE ; WOMEN ; CANCER ; TRANSMISSION ; ASSOCIATION ; COUPLES ; CAVITY
英文摘要

Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected simultaneously from 2566 men in rural China. Using general primer-mediated (SPF1/GP6+) PCR and sequencing, HPV testing results were obtained from 2228 men with both valid oral and genital specimens (beta-globin-positive). The prevalence of HPV infection was 6.7% in the oral cavity and 16.9% for the external genitalia. Among 43 men (1.9%, 43/2228) with oral-genital coinfection, 60.5% (26/43) harbored an identical HPV type at both sites. The risk of oral HPV infection was higher among men with genital infection than among uninfected men (11.4% vs. 5.7%, Adjusted OR = 2.3, 95% CI: 1.6-3.4). In addition, having multiple lifetime sexual partners was a significant risk for oral-genital HPV coinfection (Adjusted OR = 2.6, 95% CI: 1.0-7.0; 2 partners vs. 1 partner). These findings provide a basis for further understanding the natural history and transmission dynamics of oral HPV infection.

语种英语
WOS记录号WOS:000363454800001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58297
专题北京大学临床肿瘤学院_遗传学研究室
作者单位1.Anyang Canc Hosp, Anyang, Henan Province, Peoples R China
2.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Genet Lab, Beijing, Peoples R China
3.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
4.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA
5.Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA
推荐引用方式
GB/T 7714
Liu, Fangfang,Hang, Dong,Deng, Qiuju,et al. Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China[J]. SCIENTIFIC REPORTS,2015,5.
APA Liu, Fangfang.,Hang, Dong.,Deng, Qiuju.,Liu, Mengfei.,Xi, Longfu.,...&Ke, Yang.(2015).Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China.SCIENTIFIC REPORTS,5.
MLA Liu, Fangfang,et al."Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China".SCIENTIFIC REPORTS 5(2015).
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