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IR@PKUHSC  > 北京大学临床肿瘤学院  > 遗传学研究室  > 期刊论文
学科主题: 临床医学
题名:
Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China
作者: Liu, Fangfang1; Hang, Dong2; Deng, Qiuju1; Liu, Mengfei1; Xi, Longfu3,4; He, Zhonghu1; Zhang, Chaoting1; Sun, Min1; Liu, Ying1; Li, Jingjing1; Pan, Yaqi1; Ning, Tao1; Guo, Chuanhai1; Liang, Yongmei1; Xu, Ruiping5; Zhang, Lixin5; Cai, Hong1; Ke, Yang1
刊名: SCIENTIFIC REPORTS
发表日期: 2015-10-27
DOI: 10.1038/srep15637
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HIV-POSITIVE MEN ; HPV INFECTION ; RISK-FACTORS ; PREVALENCE ; WOMEN ; CANCER ; TRANSMISSION ; ASSOCIATION ; COUPLES ; CAVITY
英文摘要:

Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected simultaneously from 2566 men in rural China. Using general primer-mediated (SPF1/GP6+) PCR and sequencing, HPV testing results were obtained from 2228 men with both valid oral and genital specimens (beta-globin-positive). The prevalence of HPV infection was 6.7% in the oral cavity and 16.9% for the external genitalia. Among 43 men (1.9%, 43/2228) with oral-genital coinfection, 60.5% (26/43) harbored an identical HPV type at both sites. The risk of oral HPV infection was higher among men with genital infection than among uninfected men (11.4% vs. 5.7%, Adjusted OR = 2.3, 95% CI: 1.6-3.4). In addition, having multiple lifetime sexual partners was a significant risk for oral-genital HPV coinfection (Adjusted OR = 2.6, 95% CI: 1.0-7.0; 2 partners vs. 1 partner). These findings provide a basis for further understanding the natural history and transmission dynamics of oral HPV infection.

语种: 英语
所属项目编号: 30872937 ; 81502855 ; 30930102 ; 2011CB504300 ; 2012CB910800 ; 201202014 ; 200902002 ; 7100001
项目资助者: Natural Science Foundation of China ; "973" Project of National Ministry of Science and Technology Grant ; Charity Project of National Ministry of Health ; Natural Science Foundation of Beijing
WOS记录号: WOS:000363454800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58297
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Anyang Canc Hosp, Anyang, Henan Province, Peoples R China
2.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Genet Lab, Beijing, Peoples R China
3.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
4.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA
5.Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

Recommended Citation:
Liu, Fangfang,Hang, Dong,Deng, Qiuju,et al. Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China[J]. SCIENTIFIC REPORTS,2015,5.
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