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学科主题: 临床医学
题名:
Pulse Wave Velocity as a Marker of Cognitive Impairment in the Elderly
作者: Scuteri, Angelo1; Wang, HongYu2
关键词: Arterial aging ; arterial stiffness ; cognition ; dementia ; marker ; prevention ; pulse wave velocity
刊名: JOURNAL OF ALZHEIMERS DISEASE
发表日期: 2014
DOI: 10.3233/JAD-141416
卷: suppl.4, 页:S401-S410
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: BLOOD-PRESSURE LEVELS ; END-ORGAN DAMAGE ; ARTERIAL STIFFNESS ; ALZHEIMERS-DISEASE ; HYPERTENSIVE PATIENTS ; METABOLIC SYNDROME ; OLDER SUBJECTS ; RISK-FACTORS ; MEMORY LOSS ; DEMENTIA
英文摘要:

Carotid-femoral pulse wave velocity (PWV), an index of large artery stiffness, is a good proxy of arterial aging and also an independent marker of cardiovascular disease. A consistently growing number of studies has shown a significant inverse association of arterial aging and cognitive function: the greater the PWV, the lower the cognitive performance (and the greater its decline over time)-regardless of heterogeneity in study populations, sample size, and measure of cognitive functions adopted in each study. Therefore the epidemiological evidence and the biological plausibility require adoption of strategies to foster the routine measurement of PWV and cognitive function measurements in each and every older subject, particularly those at higher cardiovascular risk. Consistently, limited available healthcare resources should be progressively shifted from a sterile differential diagnosis between Alzheimer-type and vascular dementia to interventions aimed to reduce PWV and, thus, to prevent dementia before its onset or to decrease its rate of progression.

语种: 英语
WOS记录号: WOS:000343893000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58298
Appears in Collections:北京大学首钢医院_心血管内科_期刊论文

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作者单位: 1.Hosp San Raffaele Pisana, IRCCS, Rome, Italy
2.Peking Univ, Shougang Hosp, Dept Vasc Med, Beijing 100871, Peoples R China

Recommended Citation:
Scuteri, Angelo,Wang, HongYu. Pulse Wave Velocity as a Marker of Cognitive Impairment in the Elderly[J]. JOURNAL OF ALZHEIMERS DISEASE,2014,suppl.4:S401-S410.
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