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学科主题: 基础医学
题名:
Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats
作者: Wang, Zi-jun; Yu, Bin; Zhang, Xue-qiong; Sheng, Zhao-fu; Li, Sheng-jie; Huang, Yuan-li; Cao, Qing; Cui, Xiang-yu; Cui, Su-ying; Zhang, Yong-he
关键词: depression ; sleep ; corticosterone ; stress ; EEG ; open field test ; forced swim test ; sucrose preference test
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2014-07-01
DOI: 10.1038/aps.2014.44
卷: 35, 期:7, 页:879-888
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: PSYCHIATRIC-DISORDERS ; EEG SLEEP ; INSOMNIA ; STRESS ; MODEL ; NEUROBIOLOGY ; MAINTENANCE ; MODULATION ; PREDICTOR ; RESPONSES
英文摘要:

Aim: Disrupted sleep may be a prodromal symptom or a predictor of depressive disorders. In this study we investigated the relationship between depression symptoms and disrupted sleep using a novel model of stress-mimicked sleep disorders in rats.

Methods: SD rats were injected with corticosterone (10, 20 or 40 mg/kg, sc) or vehicle for 7 d. Their sleep-wake behavior was. monitored through implanted EEG and EMG electrodes. Their depressive behaviors were assessed using forced swim test, open field test and sucrose preference test.

Results: The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep. All depressive behavioral tests did not show significant difference across the groups. However, individual correlation analysis revealed statistically significance: the immobility time (despair) was negatively correlated with REM sleep latency, slow wave sleep (SWS) time ratio, SWS bouts and delta power density, and it was positively correlated with REM sleep bouts and beta power density. Meanwhile, sucrose preference (anhedonia) was positively correlated with total sleep time and light sleep bouts, and it was negatively correlated with the REM sleep time ratio.

Conclusion: In stress-mimicked rats, sleep disturbances are a predictor of depressive disorders, and certain symptoms of depression may be related to the disruption of several specific sleep parameters.

语种: 英语
所属项目编号: 81173031 ; 81202511 ; 81302746
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000338910500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58303
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Zi-jun,Yu, Bin,Zhang, Xue-qiong,et al. Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats[J]. ACTA PHARMACOLOGICA SINICA,2014,35(7):879-888.
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