IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats
Wang, Zi-jun; Yu, Bin; Zhang, Xue-qiong; Sheng, Zhao-fu; Li, Sheng-jie; Huang, Yuan-li; Cao, Qing; Cui, Xiang-yu; Cui, Su-ying; Zhang, Yong-he
关键词depression sleep corticosterone stress EEG open field test forced swim test sucrose preference test
刊名ACTA PHARMACOLOGICA SINICA
2014-07-01
DOI10.1038/aps.2014.44
35期:7页:879-888
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PSYCHIATRIC-DISORDERS ; EEG SLEEP ; INSOMNIA ; STRESS ; MODEL ; NEUROBIOLOGY ; MAINTENANCE ; MODULATION ; PREDICTOR ; RESPONSES
英文摘要

Aim: Disrupted sleep may be a prodromal symptom or a predictor of depressive disorders. In this study we investigated the relationship between depression symptoms and disrupted sleep using a novel model of stress-mimicked sleep disorders in rats.

Methods: SD rats were injected with corticosterone (10, 20 or 40 mg/kg, sc) or vehicle for 7 d. Their sleep-wake behavior was. monitored through implanted EEG and EMG electrodes. Their depressive behaviors were assessed using forced swim test, open field test and sucrose preference test.

Results: The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep. All depressive behavioral tests did not show significant difference across the groups. However, individual correlation analysis revealed statistically significance: the immobility time (despair) was negatively correlated with REM sleep latency, slow wave sleep (SWS) time ratio, SWS bouts and delta power density, and it was positively correlated with REM sleep bouts and beta power density. Meanwhile, sucrose preference (anhedonia) was positively correlated with total sleep time and light sleep bouts, and it was negatively correlated with the REM sleep time ratio.

Conclusion: In stress-mimicked rats, sleep disturbances are a predictor of depressive disorders, and certain symptoms of depression may be related to the disruption of several specific sleep parameters.

语种英语
所属项目编号81173031 ; 81202511 ; 81302746
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000338910500004
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58303
Collection北京大学基础医学院_药理学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Zi-jun,Yu, Bin,Zhang, Xue-qiong,et al. Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats[J]. ACTA PHARMACOLOGICA SINICA,2014,35(7):879-888.
APA Wang, Zi-jun.,Yu, Bin.,Zhang, Xue-qiong.,Sheng, Zhao-fu.,Li, Sheng-jie.,...&Zhang, Yong-he.(2014).Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats.ACTA PHARMACOLOGICA SINICA,35(7),879-888.
MLA Wang, Zi-jun,et al."Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats".ACTA PHARMACOLOGICA SINICA 35.7(2014):879-888.
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