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学科主题基础医学
Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats
Wang, Zi-jun; Yu, Bin; Zhang, Xue-qiong; Sheng, Zhao-fu; Li, Sheng-jie; Huang, Yuan-li; Cao, Qing; Cui, Xiang-yu; Cui, Su-ying; Zhang, Yong-he
关键词depression sleep corticosterone stress EEG open field test forced swim test sucrose preference test
刊名ACTA PHARMACOLOGICA SINICA
2014-07-01
DOI10.1038/aps.2014.44
35期:7页:879-888
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PSYCHIATRIC-DISORDERS ; EEG SLEEP ; INSOMNIA ; STRESS ; MODEL ; NEUROBIOLOGY ; MAINTENANCE ; MODULATION ; PREDICTOR ; RESPONSES
英文摘要

Aim: Disrupted sleep may be a prodromal symptom or a predictor of depressive disorders. In this study we investigated the relationship between depression symptoms and disrupted sleep using a novel model of stress-mimicked sleep disorders in rats.

Methods: SD rats were injected with corticosterone (10, 20 or 40 mg/kg, sc) or vehicle for 7 d. Their sleep-wake behavior was. monitored through implanted EEG and EMG electrodes. Their depressive behaviors were assessed using forced swim test, open field test and sucrose preference test.

Results: The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep. All depressive behavioral tests did not show significant difference across the groups. However, individual correlation analysis revealed statistically significance: the immobility time (despair) was negatively correlated with REM sleep latency, slow wave sleep (SWS) time ratio, SWS bouts and delta power density, and it was positively correlated with REM sleep bouts and beta power density. Meanwhile, sucrose preference (anhedonia) was positively correlated with total sleep time and light sleep bouts, and it was negatively correlated with the REM sleep time ratio.

Conclusion: In stress-mimicked rats, sleep disturbances are a predictor of depressive disorders, and certain symptoms of depression may be related to the disruption of several specific sleep parameters.

语种英语
WOS记录号WOS:000338910500004
项目编号81173031 ; 81202511 ; 81302746
资助机构National Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58303
专题北京大学基础医学院_药理学系
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
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Wang, Zi-jun,Yu, Bin,Zhang, Xue-qiong,et al. Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats[J]. ACTA PHARMACOLOGICA SINICA,2014,35(7):879-888.
APA Wang, Zi-jun.,Yu, Bin.,Zhang, Xue-qiong.,Sheng, Zhao-fu.,Li, Sheng-jie.,...&Zhang, Yong-he.(2014).Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats.ACTA PHARMACOLOGICA SINICA,35(7),879-888.
MLA Wang, Zi-jun,et al."Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats".ACTA PHARMACOLOGICA SINICA 35.7(2014):879-888.
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