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Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study
Chen, Tian-Jiao1; Ji, Cheng-Ye1; Hu, Yong-Hua2
关键词Genetic Heritability Lipids Puberty Twin study
刊名ACTA PAEDIATRICA
2009-06-01
DOI10.1111/j.1651-2227.2009.01257.x
98期:6页:1029-1036
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program of China ; National Natural Science Foundation of China ; Major State Basic Research Development Program of China
研究领域[WOS]Pediatrics
关键词[WOS]CORONARY HEART-DISEASE ; PLASMA-LIPIDS ; RISK-FACTORS ; SPERMATOZOA SPERMARCHE ; APOLIPOPROTEIN LEVELS ; CARDIOVASCULAR RISK ; CHOLESTEROL LEVELS ; ADOLESCENT TWINS ; FEMALE TWINS ; LIPOPROTEINS
英文摘要

Aim: To study the contribution of genes and environment on the variation of serum lipids and the effects of puberty.

Methods: In total, 314 same-sex twin pairs aged 5-18 years were studied. Puberty was marked physiologically by spermarche/menarche, and model fitting was used to analyse the genetic and environmental variance and its difference before and after puberty.

Results: Lipid levels were different before and after puberty. The genetic factor had an important influence on lipid levels; the heritability estimates of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)) and apolipoprotein E (ApoE) were between 49 and 86%. The total phenotypic variances of TC, HDL, LDL, Lp(a) and ApoE decreased after puberty, mainly as a result of decrease of genetic variance, even though the common environmental variance for HDL, Lp(a) and ApoE increased.

Conclusion: Genes and the environment have different effects on the levels of different lipids. The shared environmental effects on lipids are very important in children. The role of puberty on lipids deserves future study.

语种英语
所属项目编号30371223 ; 2001CB510310
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program of China ; National Natural Science Foundation of China ; Major State Basic Research Development Program of China
WOS记录号WOS:000266636300022
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58307
专题北京大学公共卫生学院
作者单位1.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Tian-Jiao,Ji, Cheng-Ye,Hu, Yong-Hua. Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study[J]. ACTA PAEDIATRICA,2009,98(6):1029-1036.
APA Chen, Tian-Jiao,Ji, Cheng-Ye,&Hu, Yong-Hua.(2009).Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study.ACTA PAEDIATRICA,98(6),1029-1036.
MLA Chen, Tian-Jiao,et al."Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study".ACTA PAEDIATRICA 98.6(2009):1029-1036.
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