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学科主题: 公共卫生
题名:
Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study
作者: Chen, Tian-Jiao1; Ji, Cheng-Ye1; Hu, Yong-Hua2
关键词: Genetic ; Heritability ; Lipids ; Puberty ; Twin study
刊名: ACTA PAEDIATRICA
发表日期: 2009-06-01
DOI: 10.1111/j.1651-2227.2009.01257.x
卷: 98, 期:6, 页:1029-1036
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: CORONARY HEART-DISEASE ; PLASMA-LIPIDS ; RISK-FACTORS ; SPERMATOZOA SPERMARCHE ; APOLIPOPROTEIN LEVELS ; CARDIOVASCULAR RISK ; CHOLESTEROL LEVELS ; ADOLESCENT TWINS ; FEMALE TWINS ; LIPOPROTEINS
英文摘要:

Aim: To study the contribution of genes and environment on the variation of serum lipids and the effects of puberty.

Methods: In total, 314 same-sex twin pairs aged 5-18 years were studied. Puberty was marked physiologically by spermarche/menarche, and model fitting was used to analyse the genetic and environmental variance and its difference before and after puberty.

Results: Lipid levels were different before and after puberty. The genetic factor had an important influence on lipid levels; the heritability estimates of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)) and apolipoprotein E (ApoE) were between 49 and 86%. The total phenotypic variances of TC, HDL, LDL, Lp(a) and ApoE decreased after puberty, mainly as a result of decrease of genetic variance, even though the common environmental variance for HDL, Lp(a) and ApoE increased.

Conclusion: Genes and the environment have different effects on the levels of different lipids. The shared environmental effects on lipids are very important in children. The role of puberty on lipids deserves future study.

语种: 英语
所属项目编号: 30371223 ; 2001CB510310
项目资助者: National Natural Science Foundation of China ; Major State Basic Research Development Program of China
WOS记录号: WOS:000266636300022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58307
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Tian-Jiao,Ji, Cheng-Ye,Hu, Yong-Hua. Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study[J]. ACTA PAEDIATRICA,2009,98(6):1029-1036.
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