|Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study|
|Chen, Tian-Jiao1; Ji, Cheng-Ye1; Hu, Yong-Hua2|
|关键词||Genetic Heritability Lipids Puberty Twin study|
|WOS标题词||Science & Technology|
|关键词[WOS]||CORONARY HEART-DISEASE ; PLASMA-LIPIDS ; RISK-FACTORS ; SPERMATOZOA SPERMARCHE ; APOLIPOPROTEIN LEVELS ; CARDIOVASCULAR RISK ; CHOLESTEROL LEVELS ; ADOLESCENT TWINS ; FEMALE TWINS ; LIPOPROTEINS|
Aim: To study the contribution of genes and environment on the variation of serum lipids and the effects of puberty.
Methods: In total, 314 same-sex twin pairs aged 5-18 years were studied. Puberty was marked physiologically by spermarche/menarche, and model fitting was used to analyse the genetic and environmental variance and its difference before and after puberty.
Results: Lipid levels were different before and after puberty. The genetic factor had an important influence on lipid levels; the heritability estimates of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)) and apolipoprotein E (ApoE) were between 49 and 86%. The total phenotypic variances of TC, HDL, LDL, Lp(a) and ApoE decreased after puberty, mainly as a result of decrease of genetic variance, even though the common environmental variance for HDL, Lp(a) and ApoE increased.
Conclusion: Genes and the environment have different effects on the levels of different lipids. The shared environmental effects on lipids are very important in children. The role of puberty on lipids deserves future study.
|作者单位||1.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100191, Peoples R China|
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100191, Peoples R China
|Chen, Tian-Jiao,Ji, Cheng-Ye,Hu, Yong-Hua. Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study[J]. ACTA PAEDIATRICA,2009,98(6):1029-1036.|
|APA||Chen, Tian-Jiao,Ji, Cheng-Ye,&Hu, Yong-Hua.(2009).Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study.ACTA PAEDIATRICA,98(6),1029-1036.|
|MLA||Chen, Tian-Jiao,et al."Genetic and environmental influences on serum lipids and the effects of puberty: a Chinese twin study".ACTA PAEDIATRICA 98.6(2009):1029-1036.|