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Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials
Taku, Kyoko1; Lin, Ning1,2; Cai, Donglian2; Hu, Jianwei3; Zhao, Xiaohui3; Zhang, Yumei3; Wang, Peiyu4; Melby, Melissa K.5; Hooper, Lee6; Kurzer, Mindy S.7; Mizuno, Shoichi8; Ishimi, Yoshiko9; Watanabe, Shaw5
关键词blood pressure human hypertension meta-analysis soy isoflavone supplements systematic review
刊名JOURNAL OF HYPERTENSION
2010-10-01
DOI10.1097/HJH.0b013e32833c6edb
28期:10页:1971-1982
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者Fuji Foundation for Protein Research, Osaka, Japan ; Ministry of Education, Culture, Sports, Science and Technology, Japan ; Fuji Foundation for Protein Research, Osaka, Japan ; Ministry of Education, Culture, Sports, Science and Technology, Japan
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]HEALTHY POSTMENOPAUSAL WOMEN ; ESTROGEN-RECEPTOR-ALPHA ; ENDOTHELIAL FUNCTION ; NITRIC-OXIDE ; JAPANESE WOMEN ; PHYTOESTROGEN GENISTEIN ; CARDIOVASCULAR RISK ; MENOPAUSAL WOMEN ; LDL CHOLESTEROL ; PLASMA
英文摘要

Objective Reported effects of different soy products on blood pressure vary. This systematic review and meta-analysis was performed to clarify the effects of soy isoflavone extract supplements on systolic and diastolic blood pressure (SBP and DBP) in adult humans.

Methods PubMed, CENTRAL, ICHUSHI, and CNKI were searched in June 2009 for relevant randomized placebo-controlled trials. Study data and indicators of methodological validity were independently extracted by two authors using predefined data fields. Meta-analysis was carried out in Review Manager 5.0.22.

Results Searches identified 3740 articles, of which 14 randomized controlled trials (789 participants) were included. Daily ingestion of 25-375mg soy isoflavones (aglycone equivalents) for 2-24 weeks significantly decreased SBP by 1.92 mmHg (95% confidence interval -3.45 to -0.39; P=0.01) compared with placebo (heterogeneity P=0.39, fixed effect model) in adults with normal blood pressure and prehypertension. The effect wa

语种英语
资助者Fuji Foundation for Protein Research, Osaka, Japan ; Ministry of Education, Culture, Sports, Science and Technology, Japan ; Fuji Foundation for Protein Research, Osaka, Japan ; Ministry of Education, Culture, Sports, Science and Technology, Japan
WOS记录号WOS:000281867400001
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58312
Collection北京大学公共卫生学院
作者单位1.Natl Inst Hlth & Nutr, Informat Ctr, Shinjuku Ku, Tokyo 1628636, Japan
2.Second Mil Med Univ, Changhai Hosp, Dept Clin Nutr, Shanghai, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing, Peoples R China
5.Natl Inst Hlth & Nutr, Nutr Educ Program, Tokyo 1628636, Japan
6.Univ E Anglia, Sch Med Hlth Policy & Practice, Norwich NR4 7TJ, Norfolk, England
7.Univ Minnesota, Dept Food Sci & Nutr, Minneapolis, MN 55455 USA
8.Natl Inst Hlth & Nutr, Ctr Collaborat & Partnership, Tokyo 1628636, Japan
9.Natl Inst Hlth & Nutr, Food Funct & Labeling Program, Tokyo 1628636, Japan
Recommended Citation
GB/T 7714
Taku, Kyoko,Lin, Ning,Cai, Donglian,et al. Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials[J]. JOURNAL OF HYPERTENSION,2010,28(10):1971-1982.
APA Taku, Kyoko.,Lin, Ning.,Cai, Donglian.,Hu, Jianwei.,Zhao, Xiaohui.,...&Watanabe, Shaw.(2010).Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials.JOURNAL OF HYPERTENSION,28(10),1971-1982.
MLA Taku, Kyoko,et al."Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials".JOURNAL OF HYPERTENSION 28.10(2010):1971-1982.
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