北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 消化科  > 期刊论文
学科主题: 临床医学
题名:
A five-year follow-up study on the pathological changes of gastric mucosa after H-pylori eradication
作者: Zhou, LY; Sung, JJY; Lin, SR; Jin, Z; Ding, SG; Huang, XB; Xia, ZW; Guo, HL; Liu, JJ; Chao, W
关键词: Helicobacter pylori ; gastritis, atrophic ; intestinal metaplasia ; gastric cancer
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2003
卷: 116, 期:1, 页:11-14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HELICOBACTER-PYLORI ; INTESTINAL METAPLASIA ; ATROPHIC GASTRITIS ; CANCER ; INFECTION
英文摘要:

Objectives To investigate the relationship between H. pylori infection, gastric cancer and other gastric diseases through the changes in gastric mucosa and the status of different gastric diseases within 5 years after H. pylori eradication in H. pylori-positive subjects in a high incidence region of gastric cancer.

Methods One thousand and six adults were selected from the general population in Yantai, Shandong province, a high incidence region for gastric cancer in China. Gastroscopy and Campylobacter- like organism (CLO) testing were performed on all subjects. Biopsy samples from the gastric antrum and body were obtained for histology and assessment of H. pylod infection. All H. pylori-positive subjects were then randomly divided into two groups: treatment group receiving Omeprazole Amoxicillin Clarythromycin (OAC) triple therapy and placebo as controls. These subjects were encloscopically followed up in the second and fifth year. We compared the endoscopic appearance and histology of the biopsy specimens from the same site obtained at the first and last visits.

Results All 552 H. pylori-positive subjects were randomly and evenly divided into treatment group or control group. During the five-year follow-up, the numbers of patients who continued to be negative or positive for H. pylod were 161 and 198, respectively. Statistical analysis revealed that: (1) At the initial visit, there were no significant differences in the severity and activity of inflammation, atrophy and intestinal metaplasia between the biopsy specimens from the antrum and body respectively in both groups. (2) The severity and activity of inflammation in both the antrum and body were markedly reduced after H. pylori eradication ( P = 0. 000). (3) Within five years after H. pylori eradication, intestinal metaplasia in the antrum either regressed or had no progression, while the proportion of intestinal metaplasia in the H. pylori-positive group increased significantly ( P = 0. 032). (4) After H. pylori eradication, the atrophy in both the antrum and body had no significant regression. The P value was 0. 223 and 0. 402, respectively.

Conclusions H. pylori eradication results in remarkable reduction in the severity and activity of chronic gastritis, marked resolution of intestinal metaplasia in the antrum. On the other hand, continuous H. pylori infection leads to progressive aggravation of atrophy and intestinal metaplasia.

语种: 英语
WOS记录号: WOS:000181239800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58316
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100083, Peoples R China
2.Chinese Univ Hong Kong, Endoscopy Ctr, Hong Kong, Peoples R China

Recommended Citation:
Zhou, LY,Sung, JJY,Lin, SR,et al. A five-year follow-up study on the pathological changes of gastric mucosa after H-pylori eradication[J]. CHINESE MEDICAL JOURNAL,2003,116(1):11-14.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, LY]'s Articles
[Sung, JJY]'s Articles
[Lin, SR]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, LY]‘s Articles
[Sung, JJY]‘s Articles
[Lin, SR]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace