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学科主题: 临床医学
题名:
Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese populationc
作者: Liu, F; Pan, KF; Zhang, XM; Zhang, Y; Zhang, L; Ma, JL; Dong, CX; Shen, L; Li, JY; Deng, DJ; Lin, DX; You, WC
刊名: GASTROENTEROLOGY
发表日期: 2006-06-01
DOI: 10.1053/j.gastro.2006.03.021
卷: 130, 期:7, 页:1975-1984
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HELICOBACTER-PYLORI INFECTION ; HEPATOCYTE GROWTH-FACTOR ; SYNTHASE-2 GENE ; FACTOR RECEPTOR ; STOMACH-CANCER ; FACTOR-ALPHA ; LUNG-CANCER ; POLYMORPHISM ; PROMOTER ; LESIONS
英文摘要:

Background & Aims: To screen the genetic variants in cyclooxygenase-2 (COX-2), and evaluate their effects onCOX-2 expression and risk of gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shangdong Province, an area of China, a high-risk area of GC. Methods: Genotypes were determined by polymerase chain reaction (PCR)-based denaturing high-performance liquid chromatography analysis in 248 GC cases and 1523 subjects with precancerous gastric lesions. COX-2 expression was detected by immunohistochemical analysis of biopsy specimens of 593 subjects selected at random from 1523 subjects. COX-2 transcriptional activity was examined by luciferase reporter gene assay. Results: We found an increased risk of GC in subjects with -1195 AA genotype (adjusted odds ratio [OR], 2.33; 95% confidence interval [CI]: 1.45-3.75). Stratified analysis indicated that an elevated risk of GC was observed in subjects carrying the AA genotype and Helicobacter pylori infection (OR, 3.88; 95% CI: :1.46-:10.34) or smoking (OR, 7.02; 95% CI: 2.19-22.48), and a high expression of COX-2 was found in subjects with AA genotype (OR, 1.84; 95% CI: 1.09-3.10) compared with GG genotype. The prevalence of COX-2 expression positivity varied markedly by histologic status, and the OR (OR, 5.35; 95% CI: 2.64-10.8) was significantly increased for dysplasia compared with superficial gastritis/chronic atrophic gastritis. Furthermore, tissue homogenate with H pylori infection could significantly stimulate COX-2 promoter activity driven by -1195A compared with the -1195G containing counterparts. Conclusions: These findings suggest that COX-2 polymorphisms may play an important role, at least in part, in developing GC in this high-risk population.

语种: 英语
WOS记录号: WOS:000238207500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58318
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing Inst Canc Res,Dept Canc Epidemiol, Beijing 100036, Peoples R China
2.Chinese Acad Med Sci, Inst Canc, Dept Etiol & Carcinogenesis, Beijing 100037, Peoples R China
3.Peking Union Med Coll, Beijing, Peoples R China
4.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing Inst Canc Res,Dept Med Oncol, Beijing 100871, Peoples R China
5.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing Inst Canc Res,Dept Pathol, Beijing 100871, Peoples R China
6.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing Inst Canc Res,Dept Etiol, Beijing 100871, Peoples R China

Recommended Citation:
Liu, F,Pan, KF,Zhang, XM,et al. Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese populationc[J]. GASTROENTEROLOGY,2006,130(7):1975-1984.
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