IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of A beta(1-40)
Zou, P; Ding, YN; Sha, YL; Hu, BH; Nie, SQ
关键词humanin electron microscopy a beta aggregation calcium influx neurotoxicity
刊名PEPTIDES
2003-05-01
DOI10.1016/S0196-9781(03)00131-1
24期:5页:679-685
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]AMYLOID BETA-PROTEIN ; RESCUE FACTOR HUMANIN ; ALZHEIMERS-DISEASE ; PRECURSOR PROTEIN ; NEUROPROTECTION ; HOMEOSTASIS
英文摘要

Humanin peptides (including HN, HNG and other mutants) were reported previously that antagonize neurotoxicity caused by various familial Alzheimer′s disease (FAD) genes and Abeta derivatives. Herein, we describe the aggregation dynamics and the representative morphological characteristics of Abeta(1-40) after different time of addition humanin peptides, which revealed that (a) the interactions of both HN and HNG with Abeta(1-40) induced quick and significant increase of light-scattering intensity, and (b) HNG also caused obvious morphological alteration from fibrillary to amorphous. In the meantime, the experiments also revealed that the interaction of HNG with Abeta(1-40) could decrease Abeta(1-40)-induced calcium rise, an initial event accompanying Abeta(1-40)-induced apoptosis of cultured neurons. Our results indicate that HNG can protect neurons by altering Abeta(1-40) morphology. (C) 2003 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000184783900007
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58319
专题北京大学基础医学院_生物物理学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiomed Lab, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zou, P,Ding, YN,Sha, YL,et al. Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of A beta(1-40)[J]. PEPTIDES,2003,24(5):679-685.
APA Zou, P,Ding, YN,Sha, YL,Hu, BH,&Nie, SQ.(2003).Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of A beta(1-40).PEPTIDES,24(5),679-685.
MLA Zou, P,et al."Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of A beta(1-40)".PEPTIDES 24.5(2003):679-685.
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