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学科主题: 基础医学
题名:
Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of A beta(1-40)
作者: Zou, P; Ding, YN; Sha, YL; Hu, BH; Nie, SQ
关键词: humanin ; electron microscopy ; a beta aggregation ; calcium influx ; neurotoxicity
刊名: PEPTIDES
发表日期: 2003-05-01
DOI: 10.1016/S0196-9781(03)00131-1
卷: 24, 期:5, 页:679-685
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: AMYLOID BETA-PROTEIN ; RESCUE FACTOR HUMANIN ; ALZHEIMERS-DISEASE ; PRECURSOR PROTEIN ; NEUROPROTECTION ; HOMEOSTASIS
英文摘要:

Humanin peptides (including HN, HNG and other mutants) were reported previously that antagonize neurotoxicity caused by various familial Alzheimer′s disease (FAD) genes and Abeta derivatives. Herein, we describe the aggregation dynamics and the representative morphological characteristics of Abeta(1-40) after different time of addition humanin peptides, which revealed that (a) the interactions of both HN and HNG with Abeta(1-40) induced quick and significant increase of light-scattering intensity, and (b) HNG also caused obvious morphological alteration from fibrillary to amorphous. In the meantime, the experiments also revealed that the interaction of HNG with Abeta(1-40) could decrease Abeta(1-40)-induced calcium rise, an initial event accompanying Abeta(1-40)-induced apoptosis of cultured neurons. Our results indicate that HNG can protect neurons by altering Abeta(1-40) morphology. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000184783900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58319
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiomed Lab, Beijing 100083, Peoples R China

Recommended Citation:
Zou, P,Ding, YN,Sha, YL,et al. Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of A beta(1-40)[J]. PEPTIDES,2003,24(5):679-685.
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