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学科主题: 临床医学
题名:
Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization: a randomized controlled study
作者: Li Xiao-xin; Tao Yong
关键词: idiopathic choroidal neovascularization ; subfoveal ; photodynamic therapy ; small laser spot
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-12-20
DOI: 10.3760/cma.j.issn.0366-6999.2012.24.018
卷: 125, 期:24, 页:4424-4428
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MACULAR DEGENERATION ; CLINICAL-TRIAL ; VERTEPORFIN ; MEMBRANES ; OCCULT
英文摘要:

Background Idiopathic choroidal neovascularization (ICNV) affects young patients and thus may have a significant impact on vision and life quality over a patient′s lifespan. This study was designed to compare the visual outcome and retinal pigment epithelium (RPE) damage after photodynamic therapy (PDT) with small laser spot and PDT with standard laser spot for idiopathic choroidal neovascularization (ICNV).

Methods This was a randomized controlled study. Fifty-two patients with ICNV were enrolled and randomly divided into a study group (small laser spot PDT, n=27) and a control group (standard laser spot PDT, n=25). Best corrected visual acuity (BCVA), optic coherence tomography (OCT) and fluorescein angiography (FA) findings were the main measurements. The patients were followed up 1 week, 1, 3, 6, 9 months and 1 year after PDT.

Results BCVA improvement was statistically significantly higher in the study group than the control group at 6-month ((25.53 +/- 15.01) letters vs. (14.71 +/- 11.66) letters, P=0.025) and 9-month follow-ups ((27.53 +/- 17.78) letters vs. (15.59 +/- 12.21) letters, P=0.039). At 3- and 6-month follow-ups, the quadrants of RPE damage between the two groups varied significantly (P <0.001 and P=0.023, respectively). In each follow-up, the number of cases with decreased or unchanged leakage of choroidal neovascularization by FA and reduced subretinal fluid by OCT did not vary significantly between the two groups. Ten cases (37.0%) in the study group and eight cases (32.0%) in the control group suffered from recurrent CNV (P=0.703).

Conclusions Better visual improvements, less RPE damage, a similar recurrent rate of CNV and change of subretinal fluid were observed in the small laser spot PDT group than in the standard laser spot PDT group for ICNV. Chin Med J 2012;125(24):4424-4428

语种: 英语
所属项目编号: 2011CB510200 ; 2009B04 ; 30901639
项目资助者: National Basic Research Program of China (973 Program) ; Novartis China, Beijing Novel Program ; National Natural Science Foundation of China
WOS记录号: WOS:000313933000019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58320
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Ophthalmol, Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China

Recommended Citation:
Li Xiao-xin,Tao Yong. Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization: a randomized controlled study[J]. CHINESE MEDICAL JOURNAL,2012,125(24):4424-4428.
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