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Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization: a randomized controlled study
Li Xiao-xin; Tao Yong
关键词idiopathic choroidal neovascularization subfoveal photodynamic therapy small laser spot
刊名CHINESE MEDICAL JOURNAL
2012-12-20
DOI10.3760/cma.j.issn.0366-6999.2012.24.018
125期:24页:4424-4428
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MACULAR DEGENERATION ; CLINICAL-TRIAL ; VERTEPORFIN ; MEMBRANES ; OCCULT
英文摘要

Background Idiopathic choroidal neovascularization (ICNV) affects young patients and thus may have a significant impact on vision and life quality over a patient′s lifespan. This study was designed to compare the visual outcome and retinal pigment epithelium (RPE) damage after photodynamic therapy (PDT) with small laser spot and PDT with standard laser spot for idiopathic choroidal neovascularization (ICNV).

Methods This was a randomized controlled study. Fifty-two patients with ICNV were enrolled and randomly divided into a study group (small laser spot PDT, n=27) and a control group (standard laser spot PDT, n=25). Best corrected visual acuity (BCVA), optic coherence tomography (OCT) and fluorescein angiography (FA) findings were the main measurements. The patients were followed up 1 week, 1, 3, 6, 9 months and 1 year after PDT.

Results BCVA improvement was statistically significantly higher in the study group than the control group at 6-month ((25.53 +/- 15.01) letters vs. (14.71 +/- 11.66) letters, P=0.025) and 9-month follow-ups ((27.53 +/- 17.78) letters vs. (15.59 +/- 12.21) letters, P=0.039). At 3- and 6-month follow-ups, the quadrants of RPE damage between the two groups varied significantly (P <0.001 and P=0.023, respectively). In each follow-up, the number of cases with decreased or unchanged leakage of choroidal neovascularization by FA and reduced subretinal fluid by OCT did not vary significantly between the two groups. Ten cases (37.0%) in the study group and eight cases (32.0%) in the control group suffered from recurrent CNV (P=0.703).

Conclusions Better visual improvements, less RPE damage, a similar recurrent rate of CNV and change of subretinal fluid were observed in the small laser spot PDT group than in the standard laser spot PDT group for ICNV. Chin Med J 2012;125(24):4424-4428

语种英语
WOS记录号WOS:000313933000019
项目编号2011CB510200 ; 2009B04 ; 30901639
资助机构National Basic Research Program of China (973 Program) ; Novartis China, Beijing Novel Program ; National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58320
专题北京大学第二临床医学院_眼科
作者单位Peking Univ, Peoples Hosp, Dept Ophthalmol, Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China
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GB/T 7714
Li Xiao-xin,Tao Yong. Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization: a randomized controlled study[J]. CHINESE MEDICAL JOURNAL,2012,125(24):4424-4428.
APA Li Xiao-xin,&Tao Yong.(2012).Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization: a randomized controlled study.CHINESE MEDICAL JOURNAL,125(24),4424-4428.
MLA Li Xiao-xin,et al."Small laser spot versus standard laser spot photodynamic therapy for idiopathic choroidal neovascularization: a randomized controlled study".CHINESE MEDICAL JOURNAL 125.24(2012):4424-4428.
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