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学科主题: 临床医学
题名:
The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair
作者: Zhang, Xin1; Zheng, Zhuozhao3; Liu, Ping1; Ma, Yong1; Lin, Lin1; Lang, Ning3; Fu, Xin1; Zhang, Jiying1; Ma, Kangtao2; Chen, Ping2; Zhou, Chunyan2; Ao, Yingfang1
关键词: Articular cartilage ; Decalcified cortical bone matrix (DCBM) ; Bone morphogenetic protein-4 (BMP4)
刊名: BIOMATERIALS
发表日期: 2008-12-01
DOI: 10.1016/j.biomaterials.2008.07.051
卷: 29, 期:35, 页:4616-4629
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: FULL-THICKNESS DEFECTS ; STEM-CELL NICHE ; ARTICULAR-CARTILAGE ; CHONDROGENIC DIFFERENTIATION ; IN-VITRO ; REGENERATION ; VIVO ; HYDROXYAPATITE ; ALGINATE ; ADIPOSE
英文摘要:

We reported a technique for articular cartilage repair, consisting of microfracture, a biomaterial scaffold of perforated decalcified cortical bone matrix (DCBM) and adenovirus-bone morphogenetic protein-4 (Ad-BMP4) gene therapy. In the present study, we evaluated its effects on the quality and quantity for induction of articular cartilage regeneration. Full-thickness defects were created in the articular cartilage of the trochlear groove of rabbits. Four groups were assigned: Ad-BMP4/perforated DCBM composite (group I); perforated DCBM alone without Ad-BMP4 (group II); DCBM without perforated (group III) and microfracture alone (group IV). Animals were sacrificed 6, 12 and 24 weeks postoperation. The harvested tissues were analyzed by magnetic resonance image, scanning electron microscope, histological examination and immunohistochemistry. Group I showed vigorous and rapid repair leading to regeneration of hyaline articular cartilage at 6 weeks and to complete repair of articular cartilage and subchondral bone at 12 weeks. Groups II and III completely repaired the defect with hyaline cartilage at 24 weeks, but group II was more rapid than group III in the regeneration of repair tissue. In group IV the defects were concave and filled with fibrous tissue at 24 weeks. These findings demonstrated that this composite biotechnology can rapidly repair large areas of cartilage defect with regeneration of native hyaline articular cartilage. (c) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: Chinese National Science and Technology
WOS记录号: WOS:000261864400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58325
Appears in Collections:北京大学第三临床医学院_运动医学研究所_期刊论文

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作者单位: 1.Peking Univ, Third Hosp, Dept Sports Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
3.Peking Univ, Third Hosp, Dept Diagnost Radiol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Xin,Zheng, Zhuozhao,Liu, Ping,et al. The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair[J]. BIOMATERIALS,2008,29(35):4616-4629.
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