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学科主题临床医学
The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair
Zhang, Xin1; Zheng, Zhuozhao3; Liu, Ping1; Ma, Yong1; Lin, Lin1; Lang, Ning3; Fu, Xin1; Zhang, Jiying1; Ma, Kangtao2; Chen, Ping2; Zhou, Chunyan2; Ao, Yingfang1
关键词Articular cartilage Decalcified cortical bone matrix (DCBM) Bone morphogenetic protein-4 (BMP4)
刊名BIOMATERIALS
2008-12-01
DOI10.1016/j.biomaterials.2008.07.051
29期:35页:4616-4629
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]FULL-THICKNESS DEFECTS ; STEM-CELL NICHE ; ARTICULAR-CARTILAGE ; CHONDROGENIC DIFFERENTIATION ; IN-VITRO ; REGENERATION ; VIVO ; HYDROXYAPATITE ; ALGINATE ; ADIPOSE
英文摘要

We reported a technique for articular cartilage repair, consisting of microfracture, a biomaterial scaffold of perforated decalcified cortical bone matrix (DCBM) and adenovirus-bone morphogenetic protein-4 (Ad-BMP4) gene therapy. In the present study, we evaluated its effects on the quality and quantity for induction of articular cartilage regeneration. Full-thickness defects were created in the articular cartilage of the trochlear groove of rabbits. Four groups were assigned: Ad-BMP4/perforated DCBM composite (group I); perforated DCBM alone without Ad-BMP4 (group II); DCBM without perforated (group III) and microfracture alone (group IV). Animals were sacrificed 6, 12 and 24 weeks postoperation. The harvested tissues were analyzed by magnetic resonance image, scanning electron microscope, histological examination and immunohistochemistry. Group I showed vigorous and rapid repair leading to regeneration of hyaline articular cartilage at 6 weeks and to complete repair of articular cartilage and subchondral bone at 12 weeks. Groups II and III completely repaired the defect with hyaline cartilage at 24 weeks, but group II was more rapid than group III in the regeneration of repair tissue. In group IV the defects were concave and filled with fibrous tissue at 24 weeks. These findings demonstrated that this composite biotechnology can rapidly repair large areas of cartilage defect with regeneration of native hyaline articular cartilage. (c) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000261864400006
资助机构Chinese National Science and Technology
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58325
专题北京大学第三临床医学院_运动医学研究所
北京大学基础医学院
北京大学药学院_药学院
北京大学第三临床医学院_骨科
北京大学精神卫生研究所_护理部
作者单位1.Peking Univ, Third Hosp, Dept Sports Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
3.Peking Univ, Third Hosp, Dept Diagnost Radiol, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, Xin,Zheng, Zhuozhao,Liu, Ping,et al. The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair[J]. BIOMATERIALS,2008,29(35):4616-4629.
APA Zhang, Xin.,Zheng, Zhuozhao.,Liu, Ping.,Ma, Yong.,Lin, Lin.,...&Ao, Yingfang.(2008).The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair.BIOMATERIALS,29(35),4616-4629.
MLA Zhang, Xin,et al."The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair".BIOMATERIALS 29.35(2008):4616-4629.
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