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学科主题: 药物依赖
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Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts
作者: Zhao, Li-Yan1; Zhang, Xiao-Li1; Shi, Jie1; Epstein, David H.2; Lu, Lin1
关键词: Stress ; Glucocorticoids ; Heroin-related memory ; Reconsolidation
刊名: PSYCHOPHARMACOLOGY
发表日期: 2009-04-01
DOI: 10.1007/s00213-008-1406-2
卷: 203, 期:3, 页:599-608
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: GLUCOCORTICOID-INDUCED IMPAIRMENT ; CONDITIONED PLACE PREFERENCE ; LONG-TERM-MEMORY ; BASOLATERAL AMYGDALA ; DECLARATIVE MEMORY ; COCAINE-SEEKING ; SPATIAL MEMORY ; FEAR MEMORIES ; DISRUPTING RECONSOLIDATION ; INCENTIVE-SENSITIZATION
英文摘要:

Stress and stress hormone are known to play important roles in modulating different stages of memory including reconsolidation. In a previous study, we found that treatment with stress or corticosterone after a single memory reactivation disrupted reconsolidation of a drug-related memory in rats. Here we presumed that stress after memory reactivation can effectively inhibit drug-related memory by disrupting its reconsolidation in abstinent heroin addicts.

In the present study, 21 abstinent heroin addicts learned a word list (containing ten neutral, ten heroin-related negative, and ten heroin-related positive words) on day 1; retrieval of a word list (learned 24 h earlier) was made on day 2; and immediately after retrieval, they were exposed to either a standardized psychosocial laboratory stressor (Trier Social Stress Test) or a control condition in a crossover manner. On day 3, free recall of the word list and other psychological and physical responses were assessed.

The stressor induced a significant increase in salivary free cortisol and a decrease in mood. Memory recall was significantly impaired after the stress condition. Follow-up analysis revealed that heroin-related negative and positive words (i.e., heroin-related words) were affected, whereas no effect was observed for neutral words. No changes were detected for cued recall, working memory, or attention. Stress after drug-related memory retrieval significantly decreased its subsequent recall, likely through impaired drug-related memory reconsolidation process.

Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction.

语种: 英语
所属项目编号: 2007CB512302 ; 2009CB522004 ; 2006AA02Z4D1 ; 30570576 ; 30670713
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; Natural Science Foundation of China
WOS记录号: WOS:000264266200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58328
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Natl Inst Drug Abuse, Intramural Res Program, Natl Inst Hlth, Baltimore, MD 21224 USA

Recommended Citation:
Zhao, Li-Yan,Zhang, Xiao-Li,Shi, Jie,et al. Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts[J]. PSYCHOPHARMACOLOGY,2009,203(3):599-608.
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