|Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts|
|Zhao, Li-Yan1; Zhang, Xiao-Li1; Shi, Jie1; Epstein, David H.2; Lu, Lin1|
|关键词||Stress Glucocorticoids Heroin-related memory Reconsolidation|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|类目[WOS]||Neurosciences ; Pharmacology & Pharmacy ; Psychiatry|
|研究领域[WOS]||Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry|
|关键词[WOS]||GLUCOCORTICOID-INDUCED IMPAIRMENT ; CONDITIONED PLACE PREFERENCE ; LONG-TERM-MEMORY ; BASOLATERAL AMYGDALA ; DECLARATIVE MEMORY ; COCAINE-SEEKING ; SPATIAL MEMORY ; FEAR MEMORIES ; DISRUPTING RECONSOLIDATION ; INCENTIVE-SENSITIZATION|
Stress and stress hormone are known to play important roles in modulating different stages of memory including reconsolidation. In a previous study, we found that treatment with stress or corticosterone after a single memory reactivation disrupted reconsolidation of a drug-related memory in rats. Here we presumed that stress after memory reactivation can effectively inhibit drug-related memory by disrupting its reconsolidation in abstinent heroin addicts.
In the present study, 21 abstinent heroin addicts learned a word list (containing ten neutral, ten heroin-related negative, and ten heroin-related positive words) on day 1; retrieval of a word list (learned 24 h earlier) was made on day 2; and immediately after retrieval, they were exposed to either a standardized psychosocial laboratory stressor (Trier Social Stress Test) or a control condition in a crossover manner. On day 3, free recall of the word list and other psychological and physical responses were assessed.
The stressor induced a significant increase in salivary free cortisol and a decrease in mood. Memory recall was significantly impaired after the stress condition. Follow-up analysis revealed that heroin-related negative and positive words (i.e., heroin-related words) were affected, whereas no effect was observed for neutral words. No changes were detected for cued recall, working memory, or attention. Stress after drug-related memory retrieval significantly decreased its subsequent recall, likely through impaired drug-related memory reconsolidation process.
Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction.
|项目编号||2007CB512302 ; 2009CB522004 ; 2006AA02Z4D1 ; 30570576 ; 30670713|
|资助机构||National Basic Research Program of China ; National High Technology Research and Development Program of China ; Natural Science Foundation of China|
|作者单位||1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China|
2.Natl Inst Drug Abuse, Intramural Res Program, Natl Inst Hlth, Baltimore, MD 21224 USA
|Zhao, Li-Yan,Zhang, Xiao-Li,Shi, Jie,et al. Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts[J]. PSYCHOPHARMACOLOGY,2009,203(3):599-608.|
|APA||Zhao, Li-Yan,Zhang, Xiao-Li,Shi, Jie,Epstein, David H.,&Lu, Lin.(2009).Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts.PSYCHOPHARMACOLOGY,203(3),599-608.|
|MLA||Zhao, Li-Yan,et al."Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts".PSYCHOPHARMACOLOGY 203.3(2009):599-608.|