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学科主题: 临床医学
题名:
Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia
作者: Zou, Li-qiu1; Yuan, Hui-shu1; Pei, Xin-long1; Dong, Wen-tian3; Liu, Peng-cheng2; Xie, Jing-xia1
关键词: schizophrenia ; diffusion tensor imaging ; the anterior limb of internal capsule
刊名: ACADEMIC RADIOLOGY
发表日期: 2008-03-01
DOI: 10.1016/j.acra.2007.09.026
卷: 15, 期:3, 页:285-289
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: WHITE-MATTER ; ASYMMETRY ; DISORDER ; GYRUS ; MRI
英文摘要:

Rationale and Objectives. Abnormalities in brain structure have been implicated in psychosis. Herein, we investigated the differences in fractional anisotropy (FA) and average diffusion coefficient (ADC) in the bilateral anterior limb of internal capsules between neuroleptic-naive schizophrenic patients and appropriately matched healthy controls.

Materials and Methods. Magnetic resonance imaging was performed with a 1.5 T superconductive MR scanner, and diffusion tensor imaging was carried out in 21 neuroleptic-naive schizophrenic patients and 18 matched healthy controls. FA and ADC were measured by region of interest analysis.

Results. Compared with healthy controls, the neuroleptic-naive schizophrenic patients showed significantly reduced FA in the bilateral anterior limb of the internal capsule. However, the difference in the ADC values between the patients and the controls was not significant.

Conclusions. FA of the bilateral anterior limb of the internal capsule was reduced in neuroleptic-naive schizophrenic patients, indicating that the integrity of the white matter of the bilateral thalamus-frontal connection or the bilateral thalamus-anterior cingulate gyrus connection was destroyed.

语种: 英语
WOS记录号: WOS:000253789000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58329
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
2.Peking Univ, Shenzhen Hosp, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 6, Beijing 100871, Peoples R China

Recommended Citation:
Zou, Li-qiu,Yuan, Hui-shu,Pei, Xin-long,et al. Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia[J]. ACADEMIC RADIOLOGY,2008,15(3):285-289.
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