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Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia
Zou, Li-qiu1; Yuan, Hui-shu1; Pei, Xin-long1; Dong, Wen-tian3; Liu, Peng-cheng2; Xie, Jing-xia1
关键词schizophrenia diffusion tensor imaging the anterior limb of internal capsule
刊名ACADEMIC RADIOLOGY
2008-03-01
DOI10.1016/j.acra.2007.09.026
15期:3页:285-289
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]WHITE-MATTER ; ASYMMETRY ; DISORDER ; GYRUS ; MRI
英文摘要

Rationale and Objectives. Abnormalities in brain structure have been implicated in psychosis. Herein, we investigated the differences in fractional anisotropy (FA) and average diffusion coefficient (ADC) in the bilateral anterior limb of internal capsules between neuroleptic-naive schizophrenic patients and appropriately matched healthy controls.

Materials and Methods. Magnetic resonance imaging was performed with a 1.5 T superconductive MR scanner, and diffusion tensor imaging was carried out in 21 neuroleptic-naive schizophrenic patients and 18 matched healthy controls. FA and ADC were measured by region of interest analysis.

Results. Compared with healthy controls, the neuroleptic-naive schizophrenic patients showed significantly reduced FA in the bilateral anterior limb of the internal capsule. However, the difference in the ADC values between the patients and the controls was not significant.

Conclusions. FA of the bilateral anterior limb of the internal capsule was reduced in neuroleptic-naive schizophrenic patients, indicating that the integrity of the white matter of the bilateral thalamus-frontal connection or the bilateral thalamus-anterior cingulate gyrus connection was destroyed.

语种英语
WOS记录号WOS:000253789000003
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58329
专题北京大学第三临床医学院_放射科
作者单位1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
2.Peking Univ, Shenzhen Hosp, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 6, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zou, Li-qiu,Yuan, Hui-shu,Pei, Xin-long,et al. Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia[J]. ACADEMIC RADIOLOGY,2008,15(3):285-289.
APA Zou, Li-qiu,Yuan, Hui-shu,Pei, Xin-long,Dong, Wen-tian,Liu, Peng-cheng,&Xie, Jing-xia.(2008).Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia.ACADEMIC RADIOLOGY,15(3),285-289.
MLA Zou, Li-qiu,et al."Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia".ACADEMIC RADIOLOGY 15.3(2008):285-289.
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