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学科主题临床医学
Herbal medicines for the prevention of alcoholic liver disease: A review
Ding, Ren-Bo1; Tian, Ke2; Huang, Li-Li3; He, Cheng-Wei1; Jiang, Yun1,4; Wang, Yi-Tao1; Wan, Jian-Bo1
关键词Herbal medicine Alcoholic liver disease Antioxidation Anti-inflammation Fatty acid synthesis
刊名JOURNAL OF ETHNOPHARMACOLOGY
2012-12-18
DOI10.1016/j.jep.2012.09.044
144期:3页:457-465
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]INDUCED FATTY LIVER ; ELEMENT-BINDING PROTEIN-1C ; GINKGO-BILOBA EXTRACT ; GREEN TEA EXTRACT ; OXIDATIVE STRESS ; RAT-LIVER ; HEPATOCELLULAR-CARCINOMA ; MOLECULAR-MECHANISMS ; VIRAL-HEPATITIS ; LEAF EXTRACT
英文摘要

Ethnopharmacological relevance: Long-term excess alcohol exposure leads to alcoholic liver disease (ALD)-a global health problem without effective therapeutic approach. ALD is increasingly considered as a complex and multifaceted pathological process, involving oxidative stress, inflammation and excessive fatty acid synthesis. Over the past decade, herbal medicines have attracted much attention as potential therapeutic agents in the prevention and treatment of ALD, due to their multiple targets and less toxic side effects. Several herbs, such as Cnidium monnieri (L.) Cusson (Apiaceae), Curcuma longa L. (Zingiberaceae) and Pueraria lobata (Willd.) Ohwi (Leguminosae), etc., have been shown to be quite effective and are being widely used in China today for the treatment of ALD when used alone or in combination.

Aim of the review: To review current available knowledge on herbal medicines used to prevent or treat ALD and their underlying mechanisms.

Materials and methods: We used the pre-set searching syntax and inclusion criteria to retrieve available published literature from PUBMED and Web of Science databases, all herbal medicines and their active compounds tested on ALD induced by both acute and chronic alcohol ingestion were included.

Results: A total of 40 experimental studies involving 34 herbal medicines and (or) active compounds were retrieved and reviewed. We found that all reported extracts and individual compounds from herbal medicines/natural plants could be beneficial to ALD, which might be attributed to regulate multiple critical targets involved in the pathways of oxidation, inflammation and lipid metabolism.

Conclusions: Screening chemical candidate from herbal medicine might be a promising approach to drug discovery for the prevention or treatment of ALD. However, further studies remain to be done on the systematic assessment of herbal medicines against ALD and the underlying mechanisms, as well as their quality control studies. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000313391300001
项目编号SRG009-ICMS12 ; MYRG123-ICMS12
资助机构Research Committee of the University of Macau
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58332
专题北京大学第二临床医学院_消化科
作者单位1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macao, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China
3.Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
4.Chinese Natl Engn Res Ctr Proc Procedures Prepare, Chengdu, Peoples R China
推荐引用方式
GB/T 7714
Ding, Ren-Bo,Tian, Ke,Huang, Li-Li,et al. Herbal medicines for the prevention of alcoholic liver disease: A review[J]. JOURNAL OF ETHNOPHARMACOLOGY,2012,144(3):457-465.
APA Ding, Ren-Bo.,Tian, Ke.,Huang, Li-Li.,He, Cheng-Wei.,Jiang, Yun.,...&Wan, Jian-Bo.(2012).Herbal medicines for the prevention of alcoholic liver disease: A review.JOURNAL OF ETHNOPHARMACOLOGY,144(3),457-465.
MLA Ding, Ren-Bo,et al."Herbal medicines for the prevention of alcoholic liver disease: A review".JOURNAL OF ETHNOPHARMACOLOGY 144.3(2012):457-465.
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