IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A42-induced neurodegeneration
Lin, Ran1,2; Angelin, Alessia2; Da Settimo, Federico3; Martini, Claudia3; Taliani, Sabrina3; Zhu, Shigong1; Wallace, Douglas C.2,4
关键词apoptosis Drosophila longevity mitochondria neurodegeneration TSPO
刊名AGING CELL
2014-06-01
DOI10.1111/acel.12200
13期:3页:507-518
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Geriatrics & Gerontology
研究领域[WOS]Cell Biology ; Geriatrics & Gerontology
关键词[WOS]PERIPHERAL BENZODIAZEPINE-RECEPTOR ; KDA TRANSLOCATOR PROTEIN ; DROSOPHILA-MELANOGASTER ; BREAST-CANCER ; PERMEABILITY TRANSITION ; ALZHEIMERS-DISEASE ; CELL-DEATH ; MICROGLIA ; LIGAND ; MOUSE
英文摘要

The outer mitochondrial membrane (OMM) protein, the translocator protein 18kDa (TSPO), formerly named the peripheral benzodiazepine receptor (PBR), has been proposed to participate in the pathogenesis of neurodegenerative diseases. To clarify the TSPO function, we identified the Drosophila homolog, CG2789/dTSPO, and studied the effects of its inactivation by P-element insertion, RNAi knockdown, and inhibition by ligands (PK11195, Ro5-4864). Inhibition of dTSPO inhibited wing disk apoptosis in response to -irradiation or H2O2 exposure, as well as extended male fly lifespan and inhibited A42-induced neurodegeneration in association with decreased caspase activation. Therefore, dTSPO is an essential mediator of apoptosis in Drosophila and plays a central role in controlling longevity and neurodegenerative disease, making it a promising drug target.

语种英语
WOS记录号WOS:000337523400013
项目编号NS21328 ; DK73691 ; 205844
资助机构NIH ; Simons Foundation
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58335
专题北京大学基础医学院
作者单位1.Univ Pisa, Dipartimento Farm, I-56126 Pisa, Italy
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Childrens Hosp Philadelphia, Ctr Mitochondrial & Epigen Med, Res Inst, Philadelphia, PA 19104 USA
4.Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
推荐引用方式
GB/T 7714
Lin, Ran,Angelin, Alessia,Da Settimo, Federico,et al. Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A42-induced neurodegeneration[J]. AGING CELL,2014,13(3):507-518.
APA Lin, Ran.,Angelin, Alessia.,Da Settimo, Federico.,Martini, Claudia.,Taliani, Sabrina.,...&Wallace, Douglas C..(2014).Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A42-induced neurodegeneration.AGING CELL,13(3),507-518.
MLA Lin, Ran,et al."Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A42-induced neurodegeneration".AGING CELL 13.3(2014):507-518.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Genetic analysis of (1617KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Ran]的文章
[Angelin, Alessia]的文章
[Da Settimo, Federico]的文章
百度学术
百度学术中相似的文章
[Lin, Ran]的文章
[Angelin, Alessia]的文章
[Da Settimo, Federico]的文章
必应学术
必应学术中相似的文章
[Lin, Ran]的文章
[Angelin, Alessia]的文章
[Da Settimo, Federico]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A42-induced neurodegeneration.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。