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学科主题: 基础医学
题名:
Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A42-induced neurodegeneration
作者: Lin, Ran1,2; Angelin, Alessia2; Da Settimo, Federico3; Martini, Claudia3; Taliani, Sabrina3; Zhu, Shigong1; Wallace, Douglas C.2,4
关键词: apoptosis ; Drosophila ; longevity ; mitochondria ; neurodegeneration ; TSPO
刊名: AGING CELL
发表日期: 2014-06-01
DOI: 10.1111/acel.12200
卷: 13, 期:3, 页:507-518
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Geriatrics & Gerontology
研究领域[WOS]: Cell Biology ; Geriatrics & Gerontology
关键词[WOS]: PERIPHERAL BENZODIAZEPINE-RECEPTOR ; KDA TRANSLOCATOR PROTEIN ; DROSOPHILA-MELANOGASTER ; BREAST-CANCER ; PERMEABILITY TRANSITION ; ALZHEIMERS-DISEASE ; CELL-DEATH ; MICROGLIA ; LIGAND ; MOUSE
英文摘要:

The outer mitochondrial membrane (OMM) protein, the translocator protein 18kDa (TSPO), formerly named the peripheral benzodiazepine receptor (PBR), has been proposed to participate in the pathogenesis of neurodegenerative diseases. To clarify the TSPO function, we identified the Drosophila homolog, CG2789/dTSPO, and studied the effects of its inactivation by P-element insertion, RNAi knockdown, and inhibition by ligands (PK11195, Ro5-4864). Inhibition of dTSPO inhibited wing disk apoptosis in response to -irradiation or H2O2 exposure, as well as extended male fly lifespan and inhibited A42-induced neurodegeneration in association with decreased caspase activation. Therefore, dTSPO is an essential mediator of apoptosis in Drosophila and plays a central role in controlling longevity and neurodegenerative disease, making it a promising drug target.

语种: 英语
所属项目编号: NS21328 ; DK73691 ; 205844
项目资助者: NIH ; Simons Foundation
WOS记录号: WOS:000337523400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58335
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Univ Pisa, Dipartimento Farm, I-56126 Pisa, Italy
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Childrens Hosp Philadelphia, Ctr Mitochondrial & Epigen Med, Res Inst, Philadelphia, PA 19104 USA
4.Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Recommended Citation:
Lin, Ran,Angelin, Alessia,Da Settimo, Federico,et al. Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A42-induced neurodegeneration[J]. AGING CELL,2014,13(3):507-518.
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