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学科主题: 基础医学
题名:
Curcumin-loaded poly(epsilon-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties
作者: Merrell, Jonathan G.2; McLaughlin, Shaun W.3; Tie, Lu6; Laurencin, Cato T.4; Chen, Alex F.5; Nair, Lakshmi S.1,4
关键词: anti-inflammatory ; anti-oxidant ; diabetic wound healing ; electrospinning ; nanofibres
刊名: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
发表日期: 2009-12-01
DOI: 10.1111/j.1440-1681.2009.05216.x
卷: 36, 期:12, 页:1149-1156
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Physiology
研究领域[WOS]: Pharmacology & Pharmacy ; Physiology
关键词[WOS]: CHEMOPREVENTIVE AGENT CURCUMIN ; CAPACITY ; MACROPHAGES ; INHIBITION ; IMPROVES ; THERAPY ; DAMAGE ; LONGA ; MOUSE ; CELLS
英文摘要:

P>Curcumin is a naturally occurring poly-phenolic compound with a broad range of favourable biological functions, including anti-cancer, anti-oxidant and anti-inflammatory activities. The low bioavailability and in vivo stability of curcumin require the development of suitable carrier vehicles to deliver the molecule in a sustained manner at therapeutic levels.

In the present study, we investigated the feasibility and potential of poly(caprolactone) (PCL) nanofibres as a delivery vehicle for curcumin for wound healing applications. By optimizing the electrospinning parameters, bead-free curcumin-loaded PCL nanofibres were developed.

The fibres showed sustained release of curcumin for 72 h and could be made to deliver a dose much lower than the reported cytotoxic concentration while remaining bioactive. Human foreskin fibroblast cells (HFF-1) showed more than 70% viability on curcumin-loaded nanofibres.

The anti-oxidant activity of curcumin-loaded nanofibres was demonstrated using an oxygen radical absorbance capacity (ORAC) assay and by the ability of the fibres to maintain the viability of HFF-1 cells under conditions of oxidative stress.

The curcumin-loaded nanofibres also reduced inflammatory induction, as evidenced by low levels of interleukin-6 release from mouse monocyte-macrophages seeded onto the fibres following stimulation by Escherichia coli-derived lipopolysaccharide.

The in vivo wound healing capability of the curcumin loaded PCL nanofibres was demonstrated by an increased rate of wound closure in a streptozotocin-induced diabetic mice model.

These results demonstrate that the curcumin-loaded PCL nanofibre matrix is bioactive and has potential as a wound dressing with anti-oxidant and anti-inflammatory properties.

语种: 英语
所属项目编号: R01 GMOL/L077352 ; 0855601G ; 7-08-RA-23
项目资助者: Coulter Foundation ; National Institutes of Health ; American Heart Association ; American Diabetes Association Research Award
WOS记录号: WOS:000272192300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58337
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA
2.Univ Virginia, Dept Orthopaed Surg, Charlottesville, VA USA
3.Univ Connecticut, Ctr Hlth, New England Musculoskeletal Inst, Dept Orthopaed Surg,Dept Chem Mat & Biomol Engn, Farmington, CT 06030 USA
4.Univ Connecticut, Dept Chem Mat & Biomol Engn, Storrs, CT USA
5.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA
6.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100871, Peoples R China

Recommended Citation:
Merrell, Jonathan G.,McLaughlin, Shaun W.,Tie, Lu,et al. Curcumin-loaded poly(epsilon-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2009,36(12):1149-1156.
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