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学科主题基础医学
Curcumin-loaded poly(epsilon-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties
Merrell, Jonathan G.2; McLaughlin, Shaun W.3; Tie, Lu6; Laurencin, Cato T.4; Chen, Alex F.5; Nair, Lakshmi S.1,4
关键词anti-inflammatory anti-oxidant diabetic wound healing electrospinning nanofibres
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2009-12-01
DOI10.1111/j.1440-1681.2009.05216.x
36期:12页:1149-1156
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]CHEMOPREVENTIVE AGENT CURCUMIN ; CAPACITY ; MACROPHAGES ; INHIBITION ; IMPROVES ; THERAPY ; DAMAGE ; LONGA ; MOUSE ; CELLS
英文摘要

P>Curcumin is a naturally occurring poly-phenolic compound with a broad range of favourable biological functions, including anti-cancer, anti-oxidant and anti-inflammatory activities. The low bioavailability and in vivo stability of curcumin require the development of suitable carrier vehicles to deliver the molecule in a sustained manner at therapeutic levels.

In the present study, we investigated the feasibility and potential of poly(caprolactone) (PCL) nanofibres as a delivery vehicle for curcumin for wound healing applications. By optimizing the electrospinning parameters, bead-free curcumin-loaded PCL nanofibres were developed.

The fibres showed sustained release of curcumin for 72 h and could be made to deliver a dose much lower than the reported cytotoxic concentration while remaining bioactive. Human foreskin fibroblast cells (HFF-1) showed more than 70% viability on curcumin-loaded nanofibres.

The anti-oxidant activity of curcumin-loaded nanofibres was demonstrated using an oxygen radical absorbance capacity (ORAC) assay and by the ability of the fibres to maintain the viability of HFF-1 cells under conditions of oxidative stress.

The curcumin-loaded nanofibres also reduced inflammatory induction, as evidenced by low levels of interleukin-6 release from mouse monocyte-macrophages seeded onto the fibres following stimulation by Escherichia coli-derived lipopolysaccharide.

The in vivo wound healing capability of the curcumin loaded PCL nanofibres was demonstrated by an increased rate of wound closure in a streptozotocin-induced diabetic mice model.

These results demonstrate that the curcumin-loaded PCL nanofibre matrix is bioactive and has potential as a wound dressing with anti-oxidant and anti-inflammatory properties.

语种英语
WOS记录号WOS:000272192300004
项目编号R01 GMOL/L077352 ; 0855601G ; 7-08-RA-23
资助机构Coulter Foundation ; National Institutes of Health ; American Heart Association ; American Diabetes Association Research Award
引用统计
被引频次:167[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58337
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA
2.Univ Virginia, Dept Orthopaed Surg, Charlottesville, VA USA
3.Univ Connecticut, Ctr Hlth, New England Musculoskeletal Inst, Dept Orthopaed Surg,Dept Chem Mat & Biomol Engn, Farmington, CT 06030 USA
4.Univ Connecticut, Dept Chem Mat & Biomol Engn, Storrs, CT USA
5.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA
6.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100871, Peoples R China
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GB/T 7714
Merrell, Jonathan G.,McLaughlin, Shaun W.,Tie, Lu,et al. Curcumin-loaded poly(epsilon-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2009,36(12):1149-1156.
APA Merrell, Jonathan G.,McLaughlin, Shaun W.,Tie, Lu,Laurencin, Cato T.,Chen, Alex F.,&Nair, Lakshmi S..(2009).Curcumin-loaded poly(epsilon-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,36(12),1149-1156.
MLA Merrell, Jonathan G.,et al."Curcumin-loaded poly(epsilon-caprolactone) nanofibres: Diabetic wound dressing with anti-oxidant and anti-inflammatory properties".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 36.12(2009):1149-1156.
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