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学科主题临床医学
Human Cytomegalovirus Glycoprotein B Genotypes in Chinese Hematopoietic Stem Cell Transplant Recipients
Xia, Chang-sheng; Zhao, Xiao-tao; Sun, Yuan-yuan; Zhang, Zheng
关键词Human cytomegalovirus Glycoprotein B Hematopoietic stem cell transplant
刊名INTERVIROLOGY
2012
DOI10.1159/000330303
55期:5页:342-348
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]BONE-MARROW ; ENVELOPE GLYCOPROTEIN ; SEQUENCE VARIATION ; TO-CELL ; GB ; STRAINS ; VIRUS ; PCR ; TRANSMISSION ; INFECTIONS
英文摘要

Objectives: To investigate the distribution of human cytomegalovirus (HCMV) glycoprotein B (gB) genotypes and to explore the possible relationship between gB genotypes and clinical characteristics in Chinese hematopoietic stem cell transplant (HSCT) recipients. Methods: A prospective analysis of gB genotypes was conducted on HCMV clinical isolates obtained from 102 HSCT recipients. Real-time quantitative PCR and PCR-based restriction fragment length polymorphism analysis were applied for the determination of viral loads and gB genotypes, respectively. Results: The distribution of gB genotypes was as follows: gB1, 54/102 (52.9%); gB3, 21/102 (20.6%); and mixtures, 27/102 (26.5%). The rate of viral clearance at day 21 was higher in patients infected with the gB1 genotype than in those infected with the gB3 genotype (56 and 29%, respectively; p = 0.036). In contrast, the rate of HCMV reactivation/reinfection was higher in patients infected with the gB3 genotype than in those infected with the gB1 genotype (81 and 56%, respectively; p = 0.041). Conclusions: The HCMV gB1 genotype is the most prevalent among Chinese HSCT recipients; patients infected with the gB3 genotype have more difficulty eradicating the virus and have a higher risk of reactivation/reinfection than those infected with the gB1 genotype. Copyright (C) 2011 S. Karger AG, Basel

语种英语
WOS记录号WOS:000304319000003
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58339
专题北京大学第二临床医学院
作者单位Peking Univ, Dept Clin Lab, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Xia, Chang-sheng,Zhao, Xiao-tao,Sun, Yuan-yuan,et al. Human Cytomegalovirus Glycoprotein B Genotypes in Chinese Hematopoietic Stem Cell Transplant Recipients[J]. INTERVIROLOGY,2012,55(5):342-348.
APA Xia, Chang-sheng,Zhao, Xiao-tao,Sun, Yuan-yuan,&Zhang, Zheng.(2012).Human Cytomegalovirus Glycoprotein B Genotypes in Chinese Hematopoietic Stem Cell Transplant Recipients.INTERVIROLOGY,55(5),342-348.
MLA Xia, Chang-sheng,et al."Human Cytomegalovirus Glycoprotein B Genotypes in Chinese Hematopoietic Stem Cell Transplant Recipients".INTERVIROLOGY 55.5(2012):342-348.
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