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学科主题临床医学
Understanding the role of transforming growth factor-beta signalling in the heart: Overview of studies using genetic mouse models
Xiao, Han; Zhang, You-Yi1
关键词genetic mouse model heart signalling pathway transforming growth factor-beta
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2008-03-01
DOI10.1111/j.1440-1681.2007.04876.x
35期:3页:335-341
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]TGF-BETA ; CARDIAC-HYPERTROPHY ; TRANSGENIC MICE ; TRANSCRIPTION FACTORS ; ISCHEMIA-REPERFUSION ; TARGETED DISRUPTION ; MYOCARDIAL FIBROSIS ; PRESSURE-OVERLOAD ; MAP-KINASE ; PATHWAY
英文摘要

1. In the present review, we focus on the genetic mouse models for transforming growth factor (TGF)-beta signalling, which have aided our understanding on the role of the TGF-beta signalling pathway in cardiac hypertrophy/fibrosis and the molecular mechanisms involved.

2. Knockout of TGF-beta is embryonic lethal, indicating that TGF-beta signalling plays an important role in embryonic development. In order to avoid this defect, many mouse strains with cardiac-specific targeted genes in TGF-beta signalling have been developed.

3. The TGF-beta family signalling pathway includes Smad-dependent and -independent pathways.

4. Investigations using the genetic mouse models have confirmed and uncovered the involvement of the TGF-beta/TGF-beta-activated kinase 1 (TAK1) pathway in the development of cardiac hypertrophy and fibrosis. Although the downstream cascade of TAK1-induced cardiac hypertrophy remains only partially defined, recent research indicates that the TGF-beta/TAK1/p38 pathway is involved in cardiac fibrosis

5. Smad-dependent signalling may not be involved in, or may even be inhibitory for, cardiac hypertrophy.

语种英语
WOS记录号WOS:000254296500017
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58345
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
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Xiao, Han,Zhang, You-Yi. Understanding the role of transforming growth factor-beta signalling in the heart: Overview of studies using genetic mouse models[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2008,35(3):335-341.
APA Xiao, Han,&Zhang, You-Yi.(2008).Understanding the role of transforming growth factor-beta signalling in the heart: Overview of studies using genetic mouse models.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,35(3),335-341.
MLA Xiao, Han,et al."Understanding the role of transforming growth factor-beta signalling in the heart: Overview of studies using genetic mouse models".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 35.3(2008):335-341.
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