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Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear
Yang, Cheng-Hao1; Shi, Hai-shui2; Zhu, Wei-li3; Wu, Ping3; Sun, Li-li1; Si, Ji-jian1; Liu, Meng-meng3; Zhang, Yan3; Suo, Lin3; Yang, Jian-li1,4
关键词Venlafaxine Fear conditioning Extinction Reinstatement Anxiety disorder Freezing
刊名BEHAVIOURAL BRAIN RESEARCH
2012-04-21
DOI10.1016/j.bbr.2012.02.023
230期:1页:268-273
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]MEDIAL PREFRONTAL CORTEX ; POSTTRAUMATIC-STRESS-DISORDER ; MAJOR DEPRESSIVE DISORDER ; AMYGDALA ; MEMORY ; ANTIDEPRESSANT ; PLASTICITY ; RECONSOLIDATION ; STIMULATION ; CALCINEURIN
英文摘要

Anxiety disorders, characterized by anxiety and fearfulness, are found to be able to cause abnormal emotional responses′ associated with memories of negative events, which implicate pressure on society with an increasingly large burden. Better treatment has been of concern to the community. Venlafaxine (VEN), a nonclassical antidepressant agent, is applied in the treatment of social phobia, major depression (MD) and general anxiety disorder (GAD) and, to a certain extent, posttraumatic stress disorder (PTSD), which improves working memory and spatial memory as well as ameliorates emotion by affecting specified brain regions. In this study, we committed to seek a new way for using VEN on treatment of anxiety disorders. To investigate the effect of VEN on extinction of auditory-cue conditioned fear, conditioned rats received a treatment with VEN before extinction training and tests for freezing level of within-session and between-session extinction. To investigate the effect of VEN on reinstatement, all conditioned rats received a treatment with VEN over a period for 21 days. After a rest for 7 days, two tests for freezing level were conducted. We found that: (1) VEN (40 mg/kg) treatment at 30 min prior to extinction training significantly facilitated the between-session extinction, but not the within-session extinction; (2) chronic administration with VEN (40 mg/kg) prevented the return of extinguished auditory-cue fear. These data elucidate the critical role of VEN in auditory-cue fear memory, suggesting that VEN may be an ideal choice for the exposure-based drug treatment and maintenance treatment in patients with GAD, SAD and PTSD. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000306379800032
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58353
专题中国药物依赖性研究所
作者单位1.Tianjin Med Univ, Tianjin 300070, Peoples R China
2.Tianjin Mental Hlth Ctr, Tianjin Mental Hlth Inst, Tianjin 300222, Peoples R China
3.Hebei Med Univ, Dept Biochem & Mol Biol, Basic Med Coll, Shijiazhuang 050017, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
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Yang, Cheng-Hao,Shi, Hai-shui,Zhu, Wei-li,et al. Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear[J]. BEHAVIOURAL BRAIN RESEARCH,2012,230(1):268-273.
APA Yang, Cheng-Hao.,Shi, Hai-shui.,Zhu, Wei-li.,Wu, Ping.,Sun, Li-li.,...&Yang, Jian-li.(2012).Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear.BEHAVIOURAL BRAIN RESEARCH,230(1),268-273.
MLA Yang, Cheng-Hao,et al."Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear".BEHAVIOURAL BRAIN RESEARCH 230.1(2012):268-273.
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