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学科主题: 药物依赖
题名:
Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear
作者: Yang, Cheng-Hao1; Shi, Hai-shui2; Zhu, Wei-li3; Wu, Ping3; Sun, Li-li1; Si, Ji-jian1; Liu, Meng-meng3; Zhang, Yan3; Suo, Lin3; Yang, Jian-li1,4
关键词: Venlafaxine ; Fear conditioning ; Extinction ; Reinstatement ; Anxiety disorder ; Freezing
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2012-04-21
DOI: 10.1016/j.bbr.2012.02.023
卷: 230, 期:1, 页:268-273
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: MEDIAL PREFRONTAL CORTEX ; POSTTRAUMATIC-STRESS-DISORDER ; MAJOR DEPRESSIVE DISORDER ; AMYGDALA ; MEMORY ; ANTIDEPRESSANT ; PLASTICITY ; RECONSOLIDATION ; STIMULATION ; CALCINEURIN
英文摘要:

Anxiety disorders, characterized by anxiety and fearfulness, are found to be able to cause abnormal emotional responses′ associated with memories of negative events, which implicate pressure on society with an increasingly large burden. Better treatment has been of concern to the community. Venlafaxine (VEN), a nonclassical antidepressant agent, is applied in the treatment of social phobia, major depression (MD) and general anxiety disorder (GAD) and, to a certain extent, posttraumatic stress disorder (PTSD), which improves working memory and spatial memory as well as ameliorates emotion by affecting specified brain regions. In this study, we committed to seek a new way for using VEN on treatment of anxiety disorders. To investigate the effect of VEN on extinction of auditory-cue conditioned fear, conditioned rats received a treatment with VEN before extinction training and tests for freezing level of within-session and between-session extinction. To investigate the effect of VEN on reinstatement, all conditioned rats received a treatment with VEN over a period for 21 days. After a rest for 7 days, two tests for freezing level were conducted. We found that: (1) VEN (40 mg/kg) treatment at 30 min prior to extinction training significantly facilitated the between-session extinction, but not the within-session extinction; (2) chronic administration with VEN (40 mg/kg) prevented the return of extinguished auditory-cue fear. These data elucidate the critical role of VEN in auditory-cue fear memory, suggesting that VEN may be an ideal choice for the exposure-based drug treatment and maintenance treatment in patients with GAD, SAD and PTSD. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30870895
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000306379800032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58353
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Tianjin Med Univ, Tianjin 300070, Peoples R China
2.Tianjin Mental Hlth Ctr, Tianjin Mental Hlth Inst, Tianjin 300222, Peoples R China
3.Hebei Med Univ, Dept Biochem & Mol Biol, Basic Med Coll, Shijiazhuang 050017, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Cheng-Hao,Shi, Hai-shui,Zhu, Wei-li,et al. Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear[J]. BEHAVIOURAL BRAIN RESEARCH,2012,230(1):268-273.
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