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学科主题: 临床医学
题名:
Multicenter prospective study of magnetic resonance imaging prior to breast-conserving surgery for breast cancer
作者: Liu Qian1; Liu Yinhua1; Xu Ling2; Duan Xuening1; Li Ting3; Qin Naishan4; Kang Hua5; Jiang Hongchuan6; Yang Deqi7; Qu Xiang8; Jiang Zefei9; Yu Chengze10
关键词: breast cancer ; magnetic resonance imaging ; histopathology ; breast-conserving surgery
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-07-05
DOI: 10.3760/cma.j.issn.0366-6999.20132508
卷: 127, 期:13, 页:2401-2406
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ULTRASONOGRAPHY ; TUMOR ; MRI
英文摘要:

Background This multicenter prospective study aimed to assess the utility of dynamic enhanced magnetic resonance imaging (MRI) prior to breast-conserving surgery for breast cancer.

Methods The research subjects were drawn from patients with primary early resectable breast cancer treated in the breast disease centers of six three-level hospitals in Beijing from 1 January 2010 to 31 December 2012. The participants were allocated to a breast-conserving surgery group (breast-conserving group) or a total mastectomy group (total mastectomy group). Enhanced MRI was used to measure breast volume, longest diameter of tumor and tumor volume. The correlations between these measurements and those derived from histopathologic findings were assessed. The relationships between the success rate of breast-conserving surgery and MRI- and pathology-based measurement results were statistically analyzed in the breast-conserving group.

Results The study included 461 cases in the total mastectomy group and 195 in the breast-conserving group. Allocation to these groups was based on clinical indications and patient preferences. The cut-off for concurrence between MRI- and pathology-based measurements of the longest diameter of tumor was set at 0.3 cm. In the total mastectomy group, the confidence interval for 95% concurrence of these measurements was 35.41%-44.63%. Correlation coefficients for MRI and histopathology-based measurements of breast volume, tumor volume and tumor volume/breast volume ratio were r=0.861, 0.569, and 0.600, respectively (all P <0.001). In the breast-conserving group, with 0.30 cm taken as the cut-off for concurrence, the 95% confidence interval for MRI and pathology-based measurements of the longest diameter of tumor was 29.98%-44.01%. The subjective and objective success rates for breast-conserving surgery were 100% and 88.54%, respectively.

Conclusions There were significant correlations between dynamic enhanced MRI- and histopathology-based measurements of the longest diameter of breast lesions, breast and tumor volumes, and breast volume/tumor volume ratios. Preoperative MRI examination improves the success rate of breast-conserving surgery.

语种: 英语
所属项目编号: D090507043409010 ; Z131107002213007
项目资助者: Bejing Municipal Science and Technology Commission ; Capital Medical Development Fund Project ; Clinical Features Research of Capital
WOS记录号: WOS:000339470600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58360
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Gen Surg, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Oncol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Pathol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Radiol, Beijing 100034, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Breast Dis Ctr, Dept Gen Surg, Beijing 100053, Peoples R China
6.Beijing Chao Yang Hosp, Dept Gen Surg, Breast Dis Ctr, Beijing 100020, Peoples R China
7.Peking Univ, Peoples Hosp, Breast Dis Ctr, Dept Gen Surg, Beijing 100044, Peoples R China
8.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Breast Dis Ctr, Beijing 100050, Peoples R China
9.Peoples Liberat Army, Hosp 307, Breast Dis Ctr, Dept Oncol, Beijing 100071, Peoples R China
10.Peoples Liberat Army, Hosp 307, Breast Dis Ctr, Dept Gen Surg, Beijing 100071, Peoples R China

Recommended Citation:
Liu Qian,Liu Yinhua,Xu Ling,et al. Multicenter prospective study of magnetic resonance imaging prior to breast-conserving surgery for breast cancer[J]. CHINESE MEDICAL JOURNAL,2014,127(13):2401-2406.
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