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Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study
Zhao, Y.1; Wen, G.1; Qiao, Z.2; Xu, H.1; Sun, Q.1; Huang, H.1; Shan, S.3; Mu, Z.1; Zhang, J.1
关键词Tetra-arsenic tetra-sulfide systemic lupus erythematosus BXSB mice
刊名LUPUS
2013-04-01
DOI10.1177/0961203313478302
22期:5页:469-476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ACUTE PROMYELOCYTIC LEUKEMIA ; SYSTEMIC-LUPUS ; ERYTHEMATOSUS ; DISEASE ; ACCELERATION ; MONOCYTOSIS ; APOPTOSIS ; PATHOGENESIS ; NEPHRITIS ; CYTOKINES
英文摘要

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Arsenic trioxide (ATO) has been used in lupus-prone mice with a regulatory effect on immune abnormality. Tetra-arsenic tetra-sulfide (As4S4), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects than ATO. In this study, a pilot study was performed to investigate the effects and the mechanism of As4S4 on the lupus-prone BXSB mice. Improvement of monocytosis (p<0.05) in spleen and decreased serum interleukin-6 (IL-6) (p = 0.0277) were observed with As4S4 treatment. As4S4-treated mice exhibited amelioration of skin, liver and renal disease with mild side effects. Histological analysis revealed that As4S4 suppressed immune complex deposition, mesangial proliferation and inflammatory cell infiltration in kidney and liver. Our study support that As4S4 selectively suppresses cutaneous lupus and nephritis in BXSB mice and might be a potential treatment for SLE. Lupus (2013) 22, 469-476.

语种英语
WOS记录号WOS:000317341900009
项目编号81071296 ; 7102156
资助机构Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58361
专题北京大学第二临床医学院_皮科
作者单位1.Peking Univ, Dept Dermatol, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Dept Cent Lab, Peoples Hosp, Beijing 100044, Peoples R China
3.Tianjin Med Univ, Gen Hosp, Dept Dermatol, Tianjin, Peoples R China
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GB/T 7714
Zhao, Y.,Wen, G.,Qiao, Z.,et al. Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study[J]. LUPUS,2013,22(5):469-476.
APA Zhao, Y..,Wen, G..,Qiao, Z..,Xu, H..,Sun, Q..,...&Zhang, J..(2013).Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study.LUPUS,22(5),469-476.
MLA Zhao, Y.,et al."Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study".LUPUS 22.5(2013):469-476.
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