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学科主题: 临床医学
题名:
Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study
作者: Zhao, Y.1; Wen, G.1; Qiao, Z.2; Xu, H.1; Sun, Q.1; Huang, H.1; Shan, S.3; Mu, Z.1; Zhang, J.1
关键词: Tetra-arsenic tetra-sulfide ; systemic lupus erythematosus ; BXSB mice
刊名: LUPUS
发表日期: 2013-04-01
DOI: 10.1177/0961203313478302
卷: 22, 期:5, 页:469-476
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: ACUTE PROMYELOCYTIC LEUKEMIA ; SYSTEMIC-LUPUS ; ERYTHEMATOSUS ; DISEASE ; ACCELERATION ; MONOCYTOSIS ; APOPTOSIS ; PATHOGENESIS ; NEPHRITIS ; CYTOKINES
英文摘要:

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Arsenic trioxide (ATO) has been used in lupus-prone mice with a regulatory effect on immune abnormality. Tetra-arsenic tetra-sulfide (As4S4), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects than ATO. In this study, a pilot study was performed to investigate the effects and the mechanism of As4S4 on the lupus-prone BXSB mice. Improvement of monocytosis (p<0.05) in spleen and decreased serum interleukin-6 (IL-6) (p = 0.0277) were observed with As4S4 treatment. As4S4-treated mice exhibited amelioration of skin, liver and renal disease with mild side effects. Histological analysis revealed that As4S4 suppressed immune complex deposition, mesangial proliferation and inflammatory cell infiltration in kidney and liver. Our study support that As4S4 selectively suppresses cutaneous lupus and nephritis in BXSB mice and might be a potential treatment for SLE. Lupus (2013) 22, 469-476.

语种: 英语
所属项目编号: 81071296 ; 7102156
项目资助者: Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000317341900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58361
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Peking Univ, Dept Dermatol, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Dept Cent Lab, Peoples Hosp, Beijing 100044, Peoples R China
3.Tianjin Med Univ, Gen Hosp, Dept Dermatol, Tianjin, Peoples R China

Recommended Citation:
Zhao, Y.,Wen, G.,Qiao, Z.,et al. Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study[J]. LUPUS,2013,22(5):469-476.
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