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学科主题: 临床医学
题名:
Identification of new susceptibility loci for IgA nephropathy in Han Chinese
作者: Li, Ming1,2; Foo, Jia-Nee3; Wang, Jin-Quan4; Low, Hui-Qi3; Tang, Xue-Qing1,2; Toh, Kai-Yee3; Yin, Pei-Ran1,2; Khor, Chiea-Chuen3,5,6,7; Goh, Yu-Fen3; Irwan, Ishak D.3; Xu, Ri-Cong1,2; Andiappan, Anand K.8; Bei, Jin-Xin3; Rotzschke, Olaf8; Chen, Meng-Hua9; Cheng, Ching-Yu5,6,7; Sun, Liang-Dan10,11,12; Jiang, Geng-Ru13; Wong, Tien-Yin5,6,7; Lin, Hong-Li14; Aung, Tin5,6,7; Liao, Yun-Hua15; Saw, Seang-Mei5,7,16; Ye, Kun17; Ebstein, Richard P.18; Chen, Qin-Kai19; Shi, Wei20; Chew, Soo-Hong21; Chen, Jian22; Zhang, Fu-Ren23; Li, Sheng-Ping24; Xu, Gang25; Tai, E. Shyong26,27; Wang, Li28; Chen, Nan29; Zhang, Xue-Jun10,11,12; Zeng, Yi-Xin30,31; Zhang, Hong32; Liu, Zhi-Hong4; Yu, Xue-Qing1; Liu, Jian-Jun1,3,10,11,16,33,34
刊名: NATURE COMMUNICATIONS
发表日期: 2015-06-01
DOI: 10.1038/ncomms8270
卷: 6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GENOME-WIDE ASSOCIATION ; GENE COPY NUMBER ; OXFORD CLASSIFICATION ; GENOTYPE IMPUTATION ; ALPHA-DEFENSIN ; HLA ALLELES ; POPULATION ; STRATIFICATION ; RESOURCE ; COMPLEX
英文摘要:

IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptibility loci in Han Chinese, we conduct a four-stage GWAS comprising 8,313 cases and 19,680 controls. Here, we show novel associations at ST6GAL1 on 3q27.3 (rs7634389, odds ratio (OR) = 1.13, P = 7.27 x 10(-10)), ACCS on 11p11.2 (rs2074038, OR = 1.14, P = 3.93 x 10(-9)) and ODF1-KLF10 on 8q22.3 (rs2033562, OR = 1.13, P = 1.41 x 10(-9)), validate a recently reported association at ITGAX-ITGAM on 16p11.2 (rs7190997, OR = 1.22, P = 2.26 x 10(-19)), and identify three independent signals within the DEFA locus (rs2738058, P = 1.15 x 10(-19); rs12716641, P = 9.53 x 10(-9); s9314614, P = 4.25 x 10(-9), multivariate association). The risk variants on 3q27.3 and 11p11.2 show strong association with mRNA expression levels in blood cells while allele frequencies of the risk variants within ST6GAL1, ACCS and DEFA correlate with geographical variation in IgAN prevalence. Our findings expand our understanding on IgAN genetic susceptibility and provide novel biological insights into molecular mechanisms underlying IgAN.

语种: 英语
所属项目编号: 2011A080300002 ; 20130171130008 ; 2013B051000019 ; 2012J5100031 ; 81200489 ; 20120171120087 ; 2014A030313136
项目资助者: Guangdong Department of Science &amp ; Technology Translational Medicine Center ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Science and Technology Planning Project of Guangdong Province, China ; Guangzhou Committee of Science and Technology, China ; Young Scientists Fund of National Natural Science Foundation of China ; Yong Scholars Fund for the Doctoral Program of Higher Education of China ; Natural Science Foundation of Guangdong Province, China ; Agency for Science &amp ; Technology and Research (A*STAR) of Singapore
WOS记录号: WOS:000357170300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58362
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Singapore Eye Res Inst, Singapore 169856, Singapore
2.Natl Univ Hlth Syst, Singapore 119228, Singapore
3.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
4.Minist Hlth & Guangdong Prov, Key Lab Nephrol, Guangzhou 510080, Guangdong, Peoples R China
5.Agcy Sci Technol & Res, Genome Inst Singapore, Human Genet, Singapore 138672, Singapore
6.Nanjing Univ, Sch Med, Jinling Hosp, Natl Clin Res Ctr Kidney Dis, Nanjing 210002, Jiangsu, Peoples R China
7.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 119228, Singapore
8.Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore
9.Ningxia Med Univ, Gen Hosp, Dept Nephrol, Ningxia 750004, Peoples R China
10.Anhui Med Univ, Inst Dermatol, Hefei 230032, Anhui, Peoples R China
11.Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei 230032, Anhui, Peoples R China
12.Minist Natl Sci & Technol, State Key Lab Incubat Base Dermatol, Hefei 230032, Anhui, Peoples R China
13.Shanghai Jiao Tong Univ, Sch Med, XinHua Hosp, Dept Nephrol, Shanghai 200092, Peoples R China
14.Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Liaoning, Peoples R China
15.Guangxi Med Univ, Affiliated Hosp 1, Dept Nephrol, Nanning 530021, Peoples R China
16.Natl Univ Hlth Syst, Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore
17.Peoples Hosp Guangxi Autonomous Reg, Dept Nephrol, Nanning, Guangxi, Peoples R China
18.Natl Univ Singapore, Dept Psychol, Singapore 117570, Singapore
19.Nanchang Univ, Affiliated Hosp 1, Dept Nephrol, Nanchang 330006, Jiangxi, Peoples R China
20.Guangdong Gen Hosp, Dept Nephrol, Guangzhou 510080, Guangdong, Peoples R China
21.Natl Univ Singapore, Dept Econ, Singapore 117570, Singapore
22.Fuzhou Gen Hosp Nanjing Mil Command, Dept Nephrol, Fuzhou 350025, Fujian, Peoples R China
23.Shandong Acad Med Sci, Shandong Prov Inst Dermatol & Venereol, Jinan 250000, Shandong, Peoples R China
24.Sun Yat Sen Univ, Ctr Canc, Dept Hepatobiliary Oncol, State Key Lab Oncol South China, Guangzhou 510080, Guangdong, Peoples R China
25.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Nephrol, Wuhan 430030, Hunan, Peoples R China
26.Duke Natl Univ Singapore, Grad Sch Med, Singapore 169857, Singapore
27.Natl Univ Hlth Syst, Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore
28.Sichuan Prov Peoples Hosp, Dept Nephrol, Chengdu 610072, Sichuan, Peoples R China
29.Shanghai Jiao Tong Univ, Sch Med, RuiJin Hosp, Dept Nephrol, Shanghai 200025, Peoples R China
30.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510080, Guangdong, Peoples R China
31.Chinese Acad Med Sci, Peking Union Med Coll, Beijing 100730, Peoples R China
32.Peking Univ, Inst Nephrol, Hosp 1, Div Renal, Beijing 100034, Peoples R China
33.Anhui Med Univ, Sch Biol Sci, Hefei 230032, Anhui, Peoples R China
34.Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei 230032, Anhui, Peoples R China

Recommended Citation:
Li, Ming,Foo, Jia-Nee,Wang, Jin-Quan,et al. Identification of new susceptibility loci for IgA nephropathy in Han Chinese[J]. NATURE COMMUNICATIONS,2015,6.
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