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学科主题基础医学
Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro
Zhou, Zhou; Sun, Weiliang; Liang, Ying; Gao, Yanxiang; Kong, Wei; Guan, Youfei; Feng, Juan1; Wang, Xian
刊名PPAR RESEARCH
2012
DOI10.1155/2012/145654
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]TH17 CELLS ; TRANSCRIPTIONAL REGULATION ; ACCELERATED ATHEROSCLEROSIS ; RHEUMATOID-ARTHRITIS ; ALPHA ACTIVATORS ; GENE-EXPRESSION ; RETINOIC ACID ; DISEASE ; MICE ; INTERLEUKIN-17
英文摘要

Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis. Recent findings suggest that enhanced activity of interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an important role in autoimmune diseases and inflammatory diseases. Previous papers have revealed that a lipid-lowering synthetic ligand of peroxisome proliferator-activated receptor alpha (PPAR alpha), fenofibrate, alleviates both atherosclerosis and a few nonlipid-associated autoimmune diseases such as autoimmune colitis and multiple sclerosis. However, the link between fenofibrate and Th17 cells is lacking. In the present study, we hypothesized that fenofibrate inhibited the differentiation of Th17 cells. Our results showed that fenofibrate inhibited transforming growth factor-beta (TGF-beta) and IL-6-induced differentiation of Th17 cells in vitro. However, other PPAR alpha ligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPAR alpha independent. Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation. Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases.

语种英语
WOS记录号WOS:000306021900001
项目编号2010CB912504 ; 2011CB503904 ; 81121061 ; 81000115 ; 20100001120049
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Ministry of Education Fund
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58363
专题北京大学基础医学院
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Zhou,Sun, Weiliang,Liang, Ying,et al. Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro[J]. PPAR RESEARCH,2012.
APA Zhou, Zhou.,Sun, Weiliang.,Liang, Ying.,Gao, Yanxiang.,Kong, Wei.,...&Wang, Xian.(2012).Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro.PPAR RESEARCH.
MLA Zhou, Zhou,et al."Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro".PPAR RESEARCH (2012).
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