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学科主题: 基础医学
题名:
Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro
作者: Zhou, Zhou; Sun, Weiliang; Liang, Ying; Gao, Yanxiang; Kong, Wei; Guan, Youfei; Feng, Juan1; Wang, Xian
刊名: PPAR RESEARCH
发表日期: 2012
DOI: 10.1155/2012/145654
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: TH17 CELLS ; TRANSCRIPTIONAL REGULATION ; ACCELERATED ATHEROSCLEROSIS ; RHEUMATOID-ARTHRITIS ; ALPHA ACTIVATORS ; GENE-EXPRESSION ; RETINOIC ACID ; DISEASE ; MICE ; INTERLEUKIN-17
英文摘要:

Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis. Recent findings suggest that enhanced activity of interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an important role in autoimmune diseases and inflammatory diseases. Previous papers have revealed that a lipid-lowering synthetic ligand of peroxisome proliferator-activated receptor alpha (PPAR alpha), fenofibrate, alleviates both atherosclerosis and a few nonlipid-associated autoimmune diseases such as autoimmune colitis and multiple sclerosis. However, the link between fenofibrate and Th17 cells is lacking. In the present study, we hypothesized that fenofibrate inhibited the differentiation of Th17 cells. Our results showed that fenofibrate inhibited transforming growth factor-beta (TGF-beta) and IL-6-induced differentiation of Th17 cells in vitro. However, other PPAR alpha ligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPAR alpha independent. Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation. Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases.

语种: 英语
所属项目编号: 2010CB912504 ; 2011CB503904 ; 81121061 ; 81000115 ; 20100001120049
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; Ministry of Education Fund
WOS记录号: WOS:000306021900001
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58363
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Zhou,Sun, Weiliang,Liang, Ying,et al. Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro[J]. PPAR RESEARCH,2012.
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