IR@PKUHSC  > 北京大学药学院
学科主题药学
Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction
Yang, Dong-Hui; Ren, Xiang-Liang; Xu, Feng; Ma, Xiao-Qing; Liu, Guang-Xue; Li, Cang-Hai; Li, Chen; Cai, Shao-Qing
关键词Buyang Huanwu decoction Isoflavonoid Drug-containing urine WZS miniature pig
刊名JOURNAL OF NATURAL MEDICINES
2014
DOI10.1007/s11418-013-0756-1
68期:1页:11-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ASTRAGALUS-MEMBRANACEUS ; SOY ISOFLAVONES ; IDENTIFICATION ; PTEROCARPAN ; EQUOL ; PHARMACOLOGY ; MONGHOLICUS ; CHEMISTRY ; GENISTEIN ; DAIDZEIN
英文摘要

Buyang Huanwu decoction (BYHWD), a famous traditional Chinese medicine prescription for the treatment of cerebrovascular diseases, is composed of seven commonly used Chinese herbs-Astragali Radix, Angelicae Sinensis Radix, Paeoniae Radix Rubra, Chuanxiong Rhizoma, Carthami Flos, Persicae Semen and Pheretima. To determine the main absorptive constituents and the metabolites of BYHWD in vivo, urine samples from Wuzhishan (WZS) miniature pigs orally administered with BYHWD (13.6 g crude drugs/kg) were collected to investigate the characteristic compounds. By comparing the high-performance liquid chromatography of a drug-containing urine sample with that of a drug-free sample, 17 characteristic compounds were isolated from the methanol extract of a drug-containing urine sample by column chromatography. Their structures, including 11 isoflavanoids, 2 pterocarpanoids and 4 isoflavonoids, were identified by spectroscopic means. Of the 17 compounds, 8 (1-8) were new compounds with the following structures: 3S-7,3′,4′-trihydroxyisoflavan-3′-O-beta-d-glucuronide (1), 3S-7,3′,4′-trihydroxyisoflavan-4′-O-beta-d-glucuronide (2), 3S-7,2′,4′-trihydroxyisoflavan-2′-O-beta-d-glucuronide (3), 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan-2′-O-beta-d-glucuronide (4), 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan-2′-O-beta-d-glucuronide-6aEuro(3)-methyl ester (5), 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan-7-O-beta-d-glucuronide-6aEuro(3)-methyl ester (6), 3R-7,2′,3′-trihydroxy-4′-methoxyisoflavan-3′-O-beta-d-glucuronide-6aEuro(3)-methyl ester (7), and 3S-7,4′,5′-trihydroxy-2′,3′-dimethoxyisoflavan-5′-O-beta-d-glucuronide (8). Based on the possible relationship and metabolic pathways of the 17 compounds in vivo, 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan (isomucronulatol, 11), 6aR,11aR-3-hydroxy-9,10-dimethoxypterocarpan (methylnissolin, astrapterocarpan, 13), 7,3′-dihydroxy-4′-methoxyisoflavone (calycosin, 16) and 7-hydroxy-4′-methoxyisoflavone (formononetin, 17) were thought to be the most important absorptive original isoflavonoid constituents of BYHWD in vivo, which underwent reactions of glucuronidation, hydroxylation, demethylation and reduction. The other 13 compounds were deduced to be their metabolites.

语种英语
WOS记录号WOS:000328211400002
项目编号30371721 ; 30830120
资助机构National Natural Science Foundation of P.R. China ; State Key Program of National Natural Science of the People&prime ; s Republic of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58372
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学医学图书馆_信息咨询部
通讯作者Cai, Shao-Qing
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Dong-Hui,Ren, Xiang-Liang,Xu, Feng,et al. Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction[J]. JOURNAL OF NATURAL MEDICINES,2014,68(1):11-21.
APA Yang, Dong-Hui.,Ren, Xiang-Liang.,Xu, Feng.,Ma, Xiao-Qing.,Liu, Guang-Xue.,...&Cai, Shao-Qing.(2014).Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction.JOURNAL OF NATURAL MEDICINES,68(1),11-21.
MLA Yang, Dong-Hui,et al."Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction".JOURNAL OF NATURAL MEDICINES 68.1(2014):11-21.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Dong-Hui]的文章
[Ren, Xiang-Liang]的文章
[Xu, Feng]的文章
百度学术
百度学术中相似的文章
[Yang, Dong-Hui]的文章
[Ren, Xiang-Liang]的文章
[Xu, Feng]的文章
必应学术
必应学术中相似的文章
[Yang, Dong-Hui]的文章
[Ren, Xiang-Liang]的文章
[Xu, Feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。