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学科主题: 药学
题名:
Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction
作者: Yang, Dong-Hui; Ren, Xiang-Liang; Xu, Feng; Ma, Xiao-Qing; Liu, Guang-Xue; Li, Cang-Hai; Li, Chen; Cai, Shao-Qing
关键词: Buyang Huanwu decoction ; Isoflavonoid ; Drug-containing urine ; WZS miniature pig
刊名: JOURNAL OF NATURAL MEDICINES
发表日期: 2014
DOI: 10.1007/s11418-013-0756-1
卷: 68, 期:1, 页:11-21
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ASTRAGALUS-MEMBRANACEUS ; SOY ISOFLAVONES ; IDENTIFICATION ; PTEROCARPAN ; EQUOL ; PHARMACOLOGY ; MONGHOLICUS ; CHEMISTRY ; GENISTEIN ; DAIDZEIN
英文摘要:

Buyang Huanwu decoction (BYHWD), a famous traditional Chinese medicine prescription for the treatment of cerebrovascular diseases, is composed of seven commonly used Chinese herbs-Astragali Radix, Angelicae Sinensis Radix, Paeoniae Radix Rubra, Chuanxiong Rhizoma, Carthami Flos, Persicae Semen and Pheretima. To determine the main absorptive constituents and the metabolites of BYHWD in vivo, urine samples from Wuzhishan (WZS) miniature pigs orally administered with BYHWD (13.6 g crude drugs/kg) were collected to investigate the characteristic compounds. By comparing the high-performance liquid chromatography of a drug-containing urine sample with that of a drug-free sample, 17 characteristic compounds were isolated from the methanol extract of a drug-containing urine sample by column chromatography. Their structures, including 11 isoflavanoids, 2 pterocarpanoids and 4 isoflavonoids, were identified by spectroscopic means. Of the 17 compounds, 8 (1-8) were new compounds with the following structures: 3S-7,3′,4′-trihydroxyisoflavan-3′-O-beta-d-glucuronide (1), 3S-7,3′,4′-trihydroxyisoflavan-4′-O-beta-d-glucuronide (2), 3S-7,2′,4′-trihydroxyisoflavan-2′-O-beta-d-glucuronide (3), 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan-2′-O-beta-d-glucuronide (4), 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan-2′-O-beta-d-glucuronide-6aEuro(3)-methyl ester (5), 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan-7-O-beta-d-glucuronide-6aEuro(3)-methyl ester (6), 3R-7,2′,3′-trihydroxy-4′-methoxyisoflavan-3′-O-beta-d-glucuronide-6aEuro(3)-methyl ester (7), and 3S-7,4′,5′-trihydroxy-2′,3′-dimethoxyisoflavan-5′-O-beta-d-glucuronide (8). Based on the possible relationship and metabolic pathways of the 17 compounds in vivo, 3R-7,2′-dihydroxy-3′,4′-dimethoxyisoflavan (isomucronulatol, 11), 6aR,11aR-3-hydroxy-9,10-dimethoxypterocarpan (methylnissolin, astrapterocarpan, 13), 7,3′-dihydroxy-4′-methoxyisoflavone (calycosin, 16) and 7-hydroxy-4′-methoxyisoflavone (formononetin, 17) were thought to be the most important absorptive original isoflavonoid constituents of BYHWD in vivo, which underwent reactions of glucuronidation, hydroxylation, demethylation and reduction. The other 13 compounds were deduced to be their metabolites.

语种: 英语
所属项目编号: 30371721 ; 30830120
项目资助者: National Natural Science Foundation of P.R. China ; State Key Program of National Natural Science of the People&prime ; s Republic of China
WOS记录号: WOS:000328211400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58372
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Dong-Hui,Ren, Xiang-Liang,Xu, Feng,et al. Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction[J]. JOURNAL OF NATURAL MEDICINES,2014,68(1):11-21.
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