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学科主题: 药学
题名:
Enabling Wittig reaction on site-specific protein modification
作者: Han, Ming-Jie; Xiong, De-Cai; Ye, Xin-Shan
刊名: CHEMICAL COMMUNICATIONS
发表日期: 2012
DOI: 10.1039/c2cc35738k
卷: 48, 期:90, 页:11079-11081
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: BIOMIMETIC TRANSAMINATION REACTION ; FREE CLICK CHEMISTRY ; COPPER-FREE ; CHEMICAL-MODIFICATION ; CROSS-METATHESIS ; LIVING SYSTEMS ; AMINO-ACIDS ; IN-VIVO ; CYCLOADDITION ; LIGATION
英文摘要:

An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag′′ was presented. A variety of functional groups could be introduced into the protein of interest.

语种: 英语
所属项目编号: 81172916 ; 2012CB822100
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000309918000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58377
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Han, Ming-Jie,Xiong, De-Cai,Ye, Xin-Shan. Enabling Wittig reaction on site-specific protein modification[J]. CHEMICAL COMMUNICATIONS,2012,48(90):11079-11081.
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