IR@PKUHSC  > 北京大学药学院
学科主题药学
Enabling Wittig reaction on site-specific protein modification
Han, Ming-Jie; Xiong, De-Cai; Ye, Xin-Shan
刊名CHEMICAL COMMUNICATIONS
2012
DOI10.1039/c2cc35738k
48期:90页:11079-11081
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
研究领域[WOS]Chemistry
关键词[WOS]BIOMIMETIC TRANSAMINATION REACTION ; FREE CLICK CHEMISTRY ; COPPER-FREE ; CHEMICAL-MODIFICATION ; CROSS-METATHESIS ; LIVING SYSTEMS ; AMINO-ACIDS ; IN-VIVO ; CYCLOADDITION ; LIGATION
英文摘要

An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag′′ was presented. A variety of functional groups could be introduced into the protein of interest.

语种英语
所属项目编号81172916 ; 2012CB822100
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号WOS:000309918000005
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58377
Collection北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Han, Ming-Jie,Xiong, De-Cai,Ye, Xin-Shan. Enabling Wittig reaction on site-specific protein modification[J]. CHEMICAL COMMUNICATIONS,2012,48(90):11079-11081.
APA Han, Ming-Jie,Xiong, De-Cai,&Ye, Xin-Shan.(2012).Enabling Wittig reaction on site-specific protein modification.CHEMICAL COMMUNICATIONS,48(90),11079-11081.
MLA Han, Ming-Jie,et al."Enabling Wittig reaction on site-specific protein modification".CHEMICAL COMMUNICATIONS 48.90(2012):11079-11081.
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